Collective Molecular Activities of the Plant: Arachis Hypogaea
Country/Region:
Philippines; Indonesia; India; France; United States; Senegal; Thailand; Argentina; Burkina Faso; SpainTraditional Medicine System:
Indian Folk; Ayurveda; SiddhaMedicinal Functions:
Antiseborrheic; Aperient; Demulcent; Emollient; Pectoral
Brazil; Bangladesh; Liberia; Sudan; Guinea; Nepal; Mongolia; France; Malawi; Ethiopia; Rwanda; Tanzania; Laos; Argentina; Bolivia; Cameroon; Cote d'Ivoire; Ecuador; Benin; Ghana; Belarus; Zambia; Burkina Faso; Togo; Trinidad and Tobago; Zimbabwe; China; Thailand; Iraq; Kazakhstan; Sierra Leone; Spain; Nigeria; Ukraine; Eritrea; Uganda; Gambia; Philippines; Indonesia; Turkmenistan; United States; Sri Lanka; Mauritania; Australia; Gabon; Guinea-Bissau; Mali; Yemen; Russia; Pakistan; Angola; Myanmar; Chad; Mexico; South Africa; India; Uzbekistan; Taiwan; Senegal; Vietnam; Mozambique; Colombia; Burundi; Namibia; Niger; Tajikistan
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
181 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
121 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
116 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99717
Ingredient ID: NPC94167
Ingredient ID: NPC93888
Ingredient ID: NPC91335
Ingredient ID: NPC88053
Ingredient ID: NPC85813
Ingredient ID: NPC85488
Ingredient ID: NPC8235
Ingredient ID: NPC81989
Ingredient ID: NPC81775
Ingredient ID: NPC81010
Ingredient ID: NPC78312
Ingredient ID: NPC78074
Ingredient ID: NPC75204
Ingredient ID: NPC69189
Ingredient ID: NPC68938
Ingredient ID: NPC68779
Ingredient ID: NPC66352
Ingredient ID: NPC65089
Ingredient ID: NPC64270
Ingredient ID: NPC62045
Ingredient ID: NPC6095
Ingredient ID: NPC60445
Ingredient ID: NPC60151
Ingredient ID: NPC59754
Ingredient ID: NPC59650
Ingredient ID: NPC58309
Ingredient ID: NPC58190
Ingredient ID: NPC55412
Ingredient ID: NPC5413
Ingredient ID: NPC50047
Ingredient ID: NPC491218
Ingredient ID: NPC490427
Ingredient ID: NPC490058
Ingredient ID: NPC489910
Ingredient ID: NPC489909
Ingredient ID: NPC489908
Ingredient ID: NPC489907
Ingredient ID: NPC489904
Ingredient ID: NPC489899
Ingredient ID: NPC489877
Ingredient ID: NPC48623
Ingredient ID: NPC478341
Ingredient ID: NPC478340
Ingredient ID: NPC478339
Ingredient ID: NPC478338
Ingredient ID: NPC478337
Ingredient ID: NPC44192
Ingredient ID: NPC42471
Ingredient ID: NPC424
Ingredient ID: NPC39426
Ingredient ID: NPC39064
Ingredient ID: NPC33666
Ingredient ID: NPC328788
Ingredient ID: NPC328447
Ingredient ID: NPC327488
Ingredient ID: NPC322899
Ingredient ID: NPC321850
Ingredient ID: NPC321251
Ingredient ID: NPC317120
Ingredient ID: NPC316926
Ingredient ID: NPC313955
Ingredient ID: NPC312800
Ingredient ID: NPC312018
Ingredient ID: NPC310758
Ingredient ID: NPC305378
Ingredient ID: NPC304898
Ingredient ID: NPC30489
Ingredient ID: NPC303422
Ingredient ID: NPC301696
Ingredient ID: NPC301583
Ingredient ID: NPC300326
Ingredient ID: NPC29883
Ingredient ID: NPC2969
Ingredient ID: NPC295644
Ingredient ID: NPC294902
Ingredient ID: NPC294548
Ingredient ID: NPC294409
Ingredient ID: NPC291428
Ingredient ID: NPC290319
Ingredient ID: NPC285322
Ingredient ID: NPC283823
Ingredient ID: NPC283309
Ingredient ID: NPC281686
Ingredient ID: NPC280834
Ingredient ID: NPC280749
Ingredient ID: NPC280717
Ingredient ID: NPC279121
Ingredient ID: NPC279026
Ingredient ID: NPC278010
Ingredient ID: NPC27717
Ingredient ID: NPC272614
Ingredient ID: NPC271027
Ingredient ID: NPC270796
Ingredient ID: NPC269980
Ingredient ID: NPC269919
Ingredient ID: NPC26906
Ingredient ID: NPC265305
Ingredient ID: NPC262911
Ingredient ID: NPC261831
Ingredient ID: NPC257980
Ingredient ID: NPC257582
Ingredient ID: NPC257256
Ingredient ID: NPC248573
Ingredient ID: NPC246679
Ingredient ID: NPC246358
Ingredient ID: NPC242580
Ingredient ID: NPC237812
Ingredient ID: NPC236202
Ingredient ID: NPC234560
Ingredient ID: NPC233533
Ingredient ID: NPC230301
Ingredient ID: NPC228346
Ingredient ID: NPC226855
Ingredient ID: NPC226453
Ingredient ID: NPC226259
Ingredient ID: NPC226108
Ingredient ID: NPC226027
Ingredient ID: NPC22130
Ingredient ID: NPC220825
Ingredient ID: NPC219622
Ingredient ID: NPC219143
Ingredient ID: NPC216630
Ingredient ID: NPC214502
Ingredient ID: NPC213876
Ingredient ID: NPC209970
Ingredient ID: NPC208793
Ingredient ID: NPC208620
Ingredient ID: NPC206949
Ingredient ID: NPC203468
Ingredient ID: NPC202742
Ingredient ID: NPC201844
Ingredient ID: NPC201284
Ingredient ID: NPC199072
Ingredient ID: NPC196776
Ingredient ID: NPC190810
Ingredient ID: NPC189436
Ingredient ID: NPC187770
Ingredient ID: NPC185755
Ingredient ID: NPC185497
Ingredient ID: NPC181153
Ingredient ID: NPC17810
Ingredient ID: NPC174246
Ingredient ID: NPC173365
Ingredient ID: NPC170103
Ingredient ID: NPC1682
Ingredient ID: NPC167400
Ingredient ID: NPC165525
Ingredient ID: NPC164706
Ingredient ID: NPC162742
Ingredient ID: NPC161571
Ingredient ID: NPC155263
Ingredient ID: NPC154186
Ingredient ID: NPC154185
Ingredient ID: NPC152451
Ingredient ID: NPC150950
Ingredient ID: NPC149803
Ingredient ID: NPC148825
Ingredient ID: NPC147983
Ingredient ID: NPC144469
Ingredient ID: NPC14426
Ingredient ID: NPC143054
Ingredient ID: NPC142871
Ingredient ID: NPC137958
Ingredient ID: NPC137167
Ingredient ID: NPC136014
Ingredient ID: NPC131624
Ingredient ID: NPC130683
Ingredient ID: NPC126681
Ingredient ID: NPC120649
Ingredient ID: NPC117572
Ingredient ID: NPC11433
Ingredient ID: NPC113733
Ingredient ID: NPC112890
Ingredient ID: NPC111888
Ingredient ID: NPC110899
Ingredient ID: NPC110297
Ingredient ID: NPC108779
Ingredient ID: NPC106653
Ingredient ID: NPC104537
Ingredient ID: NPC100971
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 724 | |
 Plant level | 7 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract | Beta Carotene (NPC17810);Ascorbate (NPC187770) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | macular degeneration | Ascorbate (NPC187770);Beta Carotene (NPC17810) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1,MMP2
NCT03522922,NCT03090048 |
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1,PPARA,DPP4,FFAR1
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
FLT3,NFKB1,GSK3B,MAPT,CDK9
NCT00329498,NCT01842139,NCT02472626,NCT00184054 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT02929888
|
Acute promyelocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1A50 |
NCT03624270
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
