Collective Molecular Activities of the Plant: Cucurbita Moschata
Plant ID: NPO25206
Plant Latin Name: Cucurbita Moschata
Taxonomy Genus: Cucurbita
Taxonomy Family: Cucurbitaceae
Plant External Links:
NCBI TaxonomyDB:
3662
Plant-of-the-World-Online:
n.a.
Country/Region:
Turkey; Indonesia; India; China; Thailand; Argentina; South KoreaTraditional Medicine System:
Indian Folk; TCM; Unani; SiddhaMedicinal Functions:
Anthelmintic; Galactogogue
Turkey; Indonesia; India; China; Thailand; Argentina; South Korea
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
107 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
75 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
74 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99744
Ingredient ID: NPC94167
Ingredient ID: NPC93888
Ingredient ID: NPC87460
Ingredient ID: NPC84868
Ingredient ID: NPC81010
Ingredient ID: NPC75873
Ingredient ID: NPC74181
Ingredient ID: NPC73143
Ingredient ID: NPC70744
Ingredient ID: NPC62045
Ingredient ID: NPC61566
Ingredient ID: NPC61473
Ingredient ID: NPC55412
Ingredient ID: NPC53122
Ingredient ID: NPC50898
Ingredient ID: NPC50731
Ingredient ID: NPC491281
Ingredient ID: NPC489907
Ingredient ID: NPC48623
Ingredient ID: NPC45782
Ingredient ID: NPC38392
Ingredient ID: NPC328447
Ingredient ID: NPC322911
Ingredient ID: NPC320323
Ingredient ID: NPC317120
Ingredient ID: NPC313179
Ingredient ID: NPC302857
Ingredient ID: NPC300326
Ingredient ID: NPC29883
Ingredient ID: NPC294902
Ingredient ID: NPC290598
Ingredient ID: NPC289758
Ingredient ID: NPC28376
Ingredient ID: NPC281686
Ingredient ID: NPC279865
Ingredient ID: NPC278434
Ingredient ID: NPC278102
Ingredient ID: NPC273709
Ingredient ID: NPC272614
Ingredient ID: NPC269919
Ingredient ID: NPC2660
Ingredient ID: NPC265173
Ingredient ID: NPC243728
Ingredient ID: NPC242580
Ingredient ID: NPC241877
Ingredient ID: NPC237812
Ingredient ID: NPC234106
Ingredient ID: NPC230301
Ingredient ID: NPC230085
Ingredient ID: NPC227738
Ingredient ID: NPC226453
Ingredient ID: NPC225710
Ingredient ID: NPC218943
Ingredient ID: NPC214610
Ingredient ID: NPC209971
Ingredient ID: NPC209970
Ingredient ID: NPC208793
Ingredient ID: NPC20791
Ingredient ID: NPC206834
Ingredient ID: NPC205355
Ingredient ID: NPC203468
Ingredient ID: NPC200254
Ingredient ID: NPC193620
Ingredient ID: NPC192744
Ingredient ID: NPC192638
Ingredient ID: NPC187770
Ingredient ID: NPC187661
Ingredient ID: NPC185755
Ingredient ID: NPC18335
Ingredient ID: NPC181941
Ingredient ID: NPC179950
Ingredient ID: NPC17810
Ingredient ID: NPC176740
Ingredient ID: NPC174246
Ingredient ID: NPC169749
Ingredient ID: NPC1682
Ingredient ID: NPC167400
Ingredient ID: NPC159630
Ingredient ID: NPC156654
Ingredient ID: NPC155296
Ingredient ID: NPC152451
Ingredient ID: NPC151106
Ingredient ID: NPC150950
Ingredient ID: NPC149184
Ingredient ID: NPC147983
Ingredient ID: NPC147821
Ingredient ID: NPC142415
Ingredient ID: NPC14079
Ingredient ID: NPC138370
Ingredient ID: NPC137958
Ingredient ID: NPC133671
Ingredient ID: NPC131192
Ingredient ID: NPC130683
Ingredient ID: NPC130308
Ingredient ID: NPC129165
Ingredient ID: NPC126681
Ingredient ID: NPC125076
Ingredient ID: NPC120635
Ingredient ID: NPC116775
Ingredient ID: NPC115854
Ingredient ID: NPC115400
Ingredient ID: NPC11433
Ingredient ID: NPC112890
Ingredient ID: NPC111897
Ingredient ID: NPC111888
Ingredient ID: NPC111409
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 656 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810);Ascorbate (NPC187770) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction | Ascorbate (NPC187770);Folic Acid (NPC147983);Beta Carotene (NPC17810);Pyridoxine (NPC269919) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1,MMP2
NCT03522922,NCT03090048,NCT00031096,NCT01387048,NCT02058628 |
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,AKR1B1,KDR,PTPN1,DPP4
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
PIM1,KDM1A,TOP2A,TP53,NFKB1,AURKB,AXL,PTPRC,SRC,FLT3
NCT01842139,NCT00329498,NCT00184054 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT02929888
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
