CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Lobelia Inflata

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO24373
Plant Latin Name: Lobelia Inflata
Taxonomy Genus: Lobelia
Taxonomy Family: Campanulaceae

Plant External Links:

NCBI TaxonomyDB: 308559
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:

China; India

Traditional Medicine System:

TCM; Homeopathy

Medicinal Functions:

Antiasthmatic; Antispasmodic; Diaphoretic; Diuretic; Emetic; Expectorant; Miscellany; Nervine

Geographical Distribution

India; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

109 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

65 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

22 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC98663

Ingredient ID: NPC94581

Ingredient ID: NPC94337

Ingredient ID: NPC93157

Ingredient ID: NPC92867

Ingredient ID: NPC92793

Ingredient ID: NPC92348

Ingredient ID: NPC86893

Ingredient ID: NPC79303

Ingredient ID: NPC77040

Ingredient ID: NPC7151

Ingredient ID: NPC66770

Ingredient ID: NPC63584

Ingredient ID: NPC62192

Ingredient ID: NPC57114

Ingredient ID: NPC52692

Ingredient ID: NPC50905

Ingredient ID: NPC48915

Ingredient ID: NPC42424

Ingredient ID: NPC40848

Ingredient ID: NPC37315

Ingredient ID: NPC36900

Ingredient ID: NPC36765

Ingredient ID: NPC35314

Ingredient ID: NPC308311

Ingredient ID: NPC30784

Ingredient ID: NPC306270

Ingredient ID: NPC305244

Ingredient ID: NPC297587

Ingredient ID: NPC292758

Ingredient ID: NPC28705

Ingredient ID: NPC285394

Ingredient ID: NPC284261

Ingredient ID: NPC282670

Ingredient ID: NPC281388

Ingredient ID: NPC280443

Ingredient ID: NPC277439

Ingredient ID: NPC273589

Ingredient ID: NPC270452

Ingredient ID: NPC265526

Ingredient ID: NPC264617

Ingredient ID: NPC262410

Ingredient ID: NPC260526

Ingredient ID: NPC259588

Ingredient ID: NPC258037

Ingredient ID: NPC254212

Ingredient ID: NPC254121

Ingredient ID: NPC248213

Ingredient ID: NPC244471

Ingredient ID: NPC239770

Ingredient ID: NPC236287

Ingredient ID: NPC234709

Ingredient ID: NPC231284

Ingredient ID: NPC229857

Ingredient ID: NPC225524

Ingredient ID: NPC2238

Ingredient ID: NPC223588

Ingredient ID: NPC223140

Ingredient ID: NPC221104

Ingredient ID: NPC220705

Ingredient ID: NPC220440

Ingredient ID: NPC219953

Ingredient ID: NPC217582

Ingredient ID: NPC217091

Ingredient ID: NPC210915

Ingredient ID: NPC209043

Ingredient ID: NPC200837

Ingredient ID: NPC200129

Ingredient ID: NPC195810

Ingredient ID: NPC185226

Ingredient ID: NPC184548

Ingredient ID: NPC184170

Ingredient ID: NPC182080

Ingredient ID: NPC181939

Ingredient ID: NPC178881

Ingredient ID: NPC178507

Ingredient ID: NPC176130

Ingredient ID: NPC174513

Ingredient ID: NPC172259

Ingredient ID: NPC171630

Ingredient ID: NPC171572

Ingredient ID: NPC17031

Ingredient ID: NPC168619

Ingredient ID: NPC165578

Ingredient ID: NPC165550

Ingredient ID: NPC161923

Ingredient ID: NPC159181

Ingredient ID: NPC157168

Ingredient ID: NPC156961

Ingredient ID: NPC156654

Ingredient ID: NPC151143

Ingredient ID: NPC149702

Ingredient ID: NPC149423

Ingredient ID: NPC146122

Ingredient ID: NPC145726

Ingredient ID: NPC143928

Ingredient ID: NPC138362

Ingredient ID: NPC137777

Ingredient ID: NPC135139

Ingredient ID: NPC133014

Ingredient ID: NPC132784

Ingredient ID: NPC130833

Ingredient ID: NPC126446

Ingredient ID: NPC125865

Ingredient ID: NPC124822

Ingredient ID: NPC123017

Ingredient ID: NPC111242

Ingredient ID: NPC106361

Ingredient ID: NPC103382

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Therapeutic Target	Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Therapeutic Target	Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	3

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00519259	Tolerability and Safety of 30, 45, and 60 mg of Sublingual Lobeline. - 1	methamphetamine dependence	(-)-Lobeline (NPC285394)	NP level
NCT00664703	Effectiveness of Lobeline in Treating Symptoms of ADHD in Adult Patients	attention deficit hyperactivity disorder	(-)-Lobeline (NPC285394)	NP level
NCT00439504	Ph1 Lobeline Interaction Study - 1	methamphetamine dependence	(-)-Lobeline (NPC285394)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	CHRNA4,CA2,CA14
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	CA2,CA14,LMNA
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	CHRNA4,CA2,CA14
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	CA14,CA2
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	CA2,CA14
Bacterial infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-1C4Z	CA2,CA14
Insomnia Disease Category: 07.Sleep-wake disorders Disease ICD-11 Code: 7A00-7A0Z	CYP2D6,CA2
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	CHRNA4 NCT00664703
Stimulant dependence including amphetamines, methamphetamine or methcathinone Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C46.2	NCT00439504,NCT00519259
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	CA2,CA14
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	CA2,LMNA
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	CA2,CYP2D6
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	CHRNA4,LMNA
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	CA2,LMNA
Aneurysm/dissection Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD50	CHRNA4
Malaria Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F40-1F45	CYP2D6
Corneal disease Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9A76-9A78	CHRNA4
Hypertensive crisis Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA03	CHRNA4
Irritable bowel syndrome Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD91	CHRNA4
Heart failure Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD10-BD1Z	CA2
Hypotension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA20-BA21	CHRNA4
Nicotine use disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C4A	CHRNA4
Duodenal ulcer Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA63	CA2
Seborrhoeic dermatitis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA81	CA2
Rheumatoid arthritis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA20	CA2
Glaucoma Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9C61	CA2
Digestive system disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DE2Z	CHRNA4
Mood disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A60-6E23	CHRNA4
Low bone mass disorder Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FB83	CA2
Depression Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A70-6A7Z	CHRNA4
Essential hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00	CA2
Inborn metabolism deficiency Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C50-5C59	CA14
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	CHRNA4
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	CA2
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	LMNA
Idiopathic pulmonary fibrosis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB03.4	CHRNA4
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	LMNA
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	LMNA
Tetralogy of Fallot Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LA88.2	CA14
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	CA2
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	CYP2D6
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	CHRNA4
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	CA2
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	CA14
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	CHRNA4

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Lobelia Inflata

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

109 All known Ingredients in Total

65 Ingredients with Acceptable Bioavailablity

22 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Carcinosarcoma of uterus

Adenocarcinoma of pancreas

Cytomegaloviral disease

Breast cancer

Solid tumour/cancer

Bacterial infection

Insomnia

Attention deficit hyperactivity disorder

Stimulant dependence including amphetamines, methamphetamine or methcathinone

Pheochromocytoma

Superficial ovarian endometriosis

Malignant neoplasms of corpus uteri, unspecified

Chikungunya virus disease

Glioblastoma of brain

Aneurysm/dissection

Malaria

Corneal disease

Hypertensive crisis

Irritable bowel syndrome

Heart failure

Hypotension

Nicotine use disorder

Duodenal ulcer

Seborrhoeic dermatitis

Rheumatoid arthritis

Glaucoma

Digestive system disease

Mood disorder

Low bone mass disorder

Depression

Essential hypertension

Inborn metabolism deficiency

Alzheimer disease

Serous cystadenoma,borderline malignancy of ovary

Malignant neoplasms of biliary tract, distal bile duct

Idiopathic pulmonary fibrosis

Diffuse large B-cell lymphomas

Mesothelioma of pleura

Tetralogy of Fallot

Urothelial carcinoma of bladder

Adenocarcinoma of bronchus or lung

Invasive carcinoma of breast

Renal cell carcinoma, chromophobe type

Germ cell tumour of testis

Malignant neoplasms of adrenal gland

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities