Collective Molecular Activities of the Plant: Paeonia Veitchii
Plant ID: NPO24267
Plant Latin Name: Paeonia Veitchii
Taxonomy Genus: Paeonia
Taxonomy Family: Paeoniaceae
Plant External Links:
NCBI TaxonomyDB:
40722
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Analgesic; Antibacterial; Antiinflammatory; Antispasmodic; Diuretic; Febrifuge; Sedative
China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
67 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
39 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
33 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC96224
Ingredient ID: NPC95920
Ingredient ID: NPC81511
Ingredient ID: NPC80360
Ingredient ID: NPC78551
Ingredient ID: NPC78500
Ingredient ID: NPC75158
Ingredient ID: NPC68889
Ingredient ID: NPC66577
Ingredient ID: NPC61818
Ingredient ID: NPC55490
Ingredient ID: NPC52464
Ingredient ID: NPC5115
Ingredient ID: NPC48645
Ingredient ID: NPC47950
Ingredient ID: NPC43728
Ingredient ID: NPC43696
Ingredient ID: NPC41476
Ingredient ID: NPC34066
Ingredient ID: NPC306195
Ingredient ID: NPC305766
Ingredient ID: NPC295317
Ingredient ID: NPC293568
Ingredient ID: NPC292419
Ingredient ID: NPC288259
Ingredient ID: NPC286904
Ingredient ID: NPC261435
Ingredient ID: NPC261084
Ingredient ID: NPC259512
Ingredient ID: NPC257990
Ingredient ID: NPC257124
Ingredient ID: NPC244297
Ingredient ID: NPC243734
Ingredient ID: NPC233538
Ingredient ID: NPC23145
Ingredient ID: NPC230221
Ingredient ID: NPC227260
Ingredient ID: NPC227211
Ingredient ID: NPC223695
Ingredient ID: NPC222102
Ingredient ID: NPC219876
Ingredient ID: NPC217226
Ingredient ID: NPC214153
Ingredient ID: NPC196776
Ingredient ID: NPC192977
Ingredient ID: NPC190552
Ingredient ID: NPC188217
Ingredient ID: NPC18642
Ingredient ID: NPC179694
Ingredient ID: NPC170826
Ingredient ID: NPC16388
Ingredient ID: NPC159481
Ingredient ID: NPC156918
Ingredient ID: NPC155985
Ingredient ID: NPC155926
Ingredient ID: NPC151516
Ingredient ID: NPC147096
Ingredient ID: NPC142753
Ingredient ID: NPC142517
Ingredient ID: NPC141393
Ingredient ID: NPC137646
Ingredient ID: NPC130683
Ingredient ID: NPC117943
Ingredient ID: NPC107603
Ingredient ID: NPC10542
Ingredient ID: NPC101785
Ingredient ID: NPC100445
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Small molecule receptor (family A GPCR) | DRD1 | Dopamine D1 receptor | P21728 | CHEMBL2056 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 20 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00218946 | Nasogastric Tube in Premature Babies - Pain and Treatment | premature birth | Sucrose (NPC130683) | NP level |
| NCT00482560 | Analgesic Effect of Breast Feeding vs Sucrose in Neonatal Screening | pain | Sucrose (NPC130683) | NP level |
| NCT00519207 | Evaluation of Topical Liposomal Lidocaine and Oral Sucrose for Treatment of Pain in Newborns Undergoing Venipuncture | pain | Sucrose (NPC130683) | NP level |
| NCT00787059 | AC6 Gene Transfer for CHF | congestive heart failure | Sucrose (NPC130683) | NP level |
| NCT00885599 | Efficacy of a Naturally-derived Mouthrinse for Gingival Inflammation | gingivitis | Thymol (NPC259512) | NP level |
| NCT00949104 | Role of Oral Sucrose in Reducing the Pain to Orogastric Tube Insertion in Preterm Neonates | pain | Sucrose (NPC130683) | NP level |
| NCT01190995 | Role of Repeated Painful Procedures in Preterm Neonates on Short Term Neurobehavioural Outcome | pain | Sucrose (NPC130683) | NP level |
| NCT01201954 | Pain Relief of Newborn Preterm Infants During Endotracheal Suctioning | pain | Sucrose (NPC130683) | NP level |
| NCT01238471 | Oral Propranolol Versus Placebo for Early Stages of Retinopathy of Prematurity: A Randomized and Prospective Study | retinopathy of prematurity | Sucrose (NPC130683) | NP level |
| NCT01503060 | Effectiveness of Parent-Led Interventions in Reducing Infant Hypersensitivity to Pain | pain | Sucrose (NPC130683) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT03718507
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
DRD1,LMNA
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
DRD1
|
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
DRD1
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
NCT02086864
|
Blood/blood-forming organ symptonDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MA14 |
HMGCR
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
HMGCR
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
HMGCR
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
