Collective Molecular Activities of the Plant: Alcea Rosea
Country/Region:
India; South Korea; JordanTraditional Medicine System:
Indian FolkMedicinal Functions:
Antiinflammatory; Astringent; Demulcent; Diuretic; Emollient; Febrifuge
Turkey; Italy; Bangladesh; France; Venezuela; Algeria; Cuba; Trinidad and Tobago; Jordan; China; Dominican Republic; Germany; Spain; Ukraine; Libya; United States; Morocco; Switzerland; New Zealand; Haiti; Bulgaria; Romania; Albania; Portugal; South Africa; Egypt; India; United Kingdom; Tunisia; Austria; Greece; Hungary; South Korea; Cyprus
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
177 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
101 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
72 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9874
Ingredient ID: NPC95126
Ingredient ID: NPC91386
Ingredient ID: NPC90105
Ingredient ID: NPC86753
Ingredient ID: NPC86438
Ingredient ID: NPC81010
Ingredient ID: NPC80807
Ingredient ID: NPC80600
Ingredient ID: NPC80374
Ingredient ID: NPC79499
Ingredient ID: NPC79391
Ingredient ID: NPC78946
Ingredient ID: NPC78026
Ingredient ID: NPC77974
Ingredient ID: NPC76296
Ingredient ID: NPC76145
Ingredient ID: NPC72422
Ingredient ID: NPC72017
Ingredient ID: NPC71853
Ingredient ID: NPC70744
Ingredient ID: NPC70100
Ingredient ID: NPC68779
Ingredient ID: NPC68617
Ingredient ID: NPC68286
Ingredient ID: NPC68014
Ingredient ID: NPC67571
Ingredient ID: NPC66399
Ingredient ID: NPC65942
Ingredient ID: NPC64123
Ingredient ID: NPC62086
Ingredient ID: NPC58190
Ingredient ID: NPC57788
Ingredient ID: NPC52472
Ingredient ID: NPC50763
Ingredient ID: NPC48744
Ingredient ID: NPC48107
Ingredient ID: NPC47844
Ingredient ID: NPC43436
Ingredient ID: NPC42676
Ingredient ID: NPC40147
Ingredient ID: NPC39896
Ingredient ID: NPC37468
Ingredient ID: NPC37288
Ingredient ID: NPC36616
Ingredient ID: NPC3649
Ingredient ID: NPC35741
Ingredient ID: NPC33090
Ingredient ID: NPC32977
Ingredient ID: NPC32553
Ingredient ID: NPC307574
Ingredient ID: NPC307506
Ingredient ID: NPC307110
Ingredient ID: NPC307050
Ingredient ID: NPC299937
Ingredient ID: NPC299856
Ingredient ID: NPC299529
Ingredient ID: NPC29883
Ingredient ID: NPC297727
Ingredient ID: NPC297011
Ingredient ID: NPC29598
Ingredient ID: NPC295946
Ingredient ID: NPC294952
Ingredient ID: NPC294902
Ingredient ID: NPC293908
Ingredient ID: NPC293017
Ingredient ID: NPC292722
Ingredient ID: NPC291789
Ingredient ID: NPC290016
Ingredient ID: NPC289688
Ingredient ID: NPC288436
Ingredient ID: NPC287301
Ingredient ID: NPC280642
Ingredient ID: NPC278434
Ingredient ID: NPC273991
Ingredient ID: NPC269613
Ingredient ID: NPC268862
Ingredient ID: NPC268342
Ingredient ID: NPC263281
Ingredient ID: NPC26314
Ingredient ID: NPC261093
Ingredient ID: NPC26080
Ingredient ID: NPC251102
Ingredient ID: NPC250482
Ingredient ID: NPC249340
Ingredient ID: NPC246581
Ingredient ID: NPC246202
Ingredient ID: NPC246162
Ingredient ID: NPC246005
Ingredient ID: NPC244776
Ingredient ID: NPC244442
Ingredient ID: NPC243728
Ingredient ID: NPC242898
Ingredient ID: NPC241784
Ingredient ID: NPC238809
Ingredient ID: NPC237207
Ingredient ID: NPC23682
Ingredient ID: NPC23678
Ingredient ID: NPC236202
Ingredient ID: NPC234017
Ingredient ID: NPC232375
Ingredient ID: NPC232227
Ingredient ID: NPC228346
Ingredient ID: NPC227632
Ingredient ID: NPC224390
Ingredient ID: NPC223834
Ingredient ID: NPC222001
Ingredient ID: NPC219876
Ingredient ID: NPC219480
Ingredient ID: NPC218943
Ingredient ID: NPC218792
Ingredient ID: NPC217650
Ingredient ID: NPC215647
Ingredient ID: NPC212866
Ingredient ID: NPC211336
Ingredient ID: NPC210532
Ingredient ID: NPC21002
Ingredient ID: NPC206280
Ingredient ID: NPC203719
Ingredient ID: NPC197285
Ingredient ID: NPC191327
Ingredient ID: NPC191271
Ingredient ID: NPC188238
Ingredient ID: NPC18816
Ingredient ID: NPC187272
Ingredient ID: NPC187169
Ingredient ID: NPC186616
Ingredient ID: NPC185768
Ingredient ID: NPC182453
Ingredient ID: NPC181664
Ingredient ID: NPC178919
Ingredient ID: NPC178815
Ingredient ID: NPC178582
Ingredient ID: NPC173883
Ingredient ID: NPC172469
Ingredient ID: NPC172195
Ingredient ID: NPC169468
Ingredient ID: NPC165219
Ingredient ID: NPC163332
Ingredient ID: NPC163326
Ingredient ID: NPC163191
Ingredient ID: NPC162521
Ingredient ID: NPC15658
Ingredient ID: NPC156304
Ingredient ID: NPC15518
Ingredient ID: NPC15482
Ingredient ID: NPC153854
Ingredient ID: NPC152600
Ingredient ID: NPC151439
Ingredient ID: NPC150361
Ingredient ID: NPC148615
Ingredient ID: NPC148174
Ingredient ID: NPC142871
Ingredient ID: NPC141733
Ingredient ID: NPC140201
Ingredient ID: NPC139397
Ingredient ID: NPC138370
Ingredient ID: NPC138113
Ingredient ID: NPC130754
Ingredient ID: NPC128248
Ingredient ID: NPC12640
Ingredient ID: NPC125665
Ingredient ID: NPC116272
Ingredient ID: NPC114239
Ingredient ID: NPC113614
Ingredient ID: NPC112959
Ingredient ID: NPC111929
Ingredient ID: NPC111888
Ingredient ID: NPC111275
Ingredient ID: NPC111212
Ingredient ID: NPC110899
Ingredient ID: NPC108811
Ingredient ID: NPC107815
Ingredient ID: NPC1075
Ingredient ID: NPC10716
Ingredient ID: NPC107091
Ingredient ID: NPC100844
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Therapeutic Target | Enzyme | KARS1 | Lysyl-tRNA synthetase | Q15046 | CHEMBL5575 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
| Therapeutic Target | Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
| Therapeutic Target | Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Therapeutic Target | Oxidoreductase | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Therapeutic Target | Oxidoreductase | HSD17B3 | Estradiol 17-beta-dehydrogenase 3 | P37058 | CHEMBL4234 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 5 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT02351622 | Caffeic Acid Tablets as a Second-line Therapy for ITP | autoimmune thrombocytopenic purpura | Caffeic Acid (NPC294902) | NP level |
| NCT04392622 | d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma | xerostomia | Limonene (NPC76145) | NP level |
| NCT04648917 | GASC1 Inhibitor Caffeic Acid for Squamous Esophageal Cell Cancer (ESCC) | esophageal cancer | Caffeic Acid (NPC294902) | NP level |
| NCT04853082 | Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution | Hepatic steatosis | Limonene (NPC76145) | NP level |
| NCT05432284 | Behavioral Pharmacology of THC and Beta-Myrcene | cannabis dependence | Myrcene (NPC138113) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1,TP53
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,MMP9,TSHR,MMP1,NPSR1,CA7
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA2,MMP2,MMP1,NPSR1,DRD1,CA7,SNCA
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
MMP9,MMP1,NPSR1,DRD1,CYP19A1
|
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
DRD1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
SNCA
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
