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Collective Molecular Activities of the Plant: Odixia Angusta


Example Image
PLANiTS DNA barcode

Click for details-----ITS

NA

Click for details-----ITS1

NA

Click for details-----ITS2

NA
Taxonomic Information

Plant ID: NPO23963
Plant Latin Name: Odixia Angusta
Taxonomy Genus: Odixia
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 125740
Plant-of-the-World-Online: n.a.

Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary

Overview of Ingredients

157 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.


116 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

67 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.





Ingredient Structrual Cards

Ingredient ID: NPC99088

Ingredient ID: NPC95704

Ingredient ID: NPC95031

Ingredient ID: NPC92085

Ingredient ID: NPC91931

Ingredient ID: NPC90040

Ingredient ID: NPC88566

Ingredient ID: NPC86545

Ingredient ID: NPC85813

Ingredient ID: NPC85233

Ingredient ID: NPC79416

Ingredient ID: NPC79056

Ingredient ID: NPC76145

Ingredient ID: NPC72141

Ingredient ID: NPC69394

Ingredient ID: NPC68889

Ingredient ID: NPC66655

Ingredient ID: NPC65959

Ingredient ID: NPC63872

Ingredient ID: NPC53403

Ingredient ID: NPC50715

Ingredient ID: NPC50701

Ingredient ID: NPC49151

Ingredient ID: NPC47781

Ingredient ID: NPC47255

Ingredient ID: NPC46801

Ingredient ID: NPC4455

Ingredient ID: NPC40818

Ingredient ID: NPC38497

Ingredient ID: NPC3649

Ingredient ID: NPC32021

Ingredient ID: NPC31290

Ingredient ID: NPC312132

Ingredient ID: NPC311810

Ingredient ID: NPC311529

Ingredient ID: NPC307168

Ingredient ID: NPC306993

Ingredient ID: NPC306296

Ingredient ID: NPC305016

Ingredient ID: NPC29710

Ingredient ID: NPC297054

Ingredient ID: NPC296473

Ingredient ID: NPC29536

Ingredient ID: NPC294548

Ingredient ID: NPC288756

Ingredient ID: NPC282363

Ingredient ID: NPC279865

Ingredient ID: NPC278023

Ingredient ID: NPC277385

Ingredient ID: NPC27657

Ingredient ID: NPC273756

Ingredient ID: NPC27184

Ingredient ID: NPC270549

Ingredient ID: NPC266371

Ingredient ID: NPC263265

Ingredient ID: NPC262505

Ingredient ID: NPC261991

Ingredient ID: NPC261831

Ingredient ID: NPC259512

Ingredient ID: NPC257188

Ingredient ID: NPC255350

Ingredient ID: NPC252074

Ingredient ID: NPC251666

Ingredient ID: NPC249164

Ingredient ID: NPC248404

Ingredient ID: NPC247844

Ingredient ID: NPC2476

Ingredient ID: NPC245807

Ingredient ID: NPC243925

Ingredient ID: NPC242881

Ingredient ID: NPC241784

Ingredient ID: NPC240504

Ingredient ID: NPC239039

Ingredient ID: NPC236705

Ingredient ID: NPC233209

Ingredient ID: NPC232375

Ingredient ID: NPC227325

Ingredient ID: NPC226973

Ingredient ID: NPC224517

Ingredient ID: NPC223110

Ingredient ID: NPC222781

Ingredient ID: NPC221743

Ingredient ID: NPC22098

Ingredient ID: NPC220615

Ingredient ID: NPC219738

Ingredient ID: NPC216919

Ingredient ID: NPC216630

Ingredient ID: NPC215932

Ingredient ID: NPC214285

Ingredient ID: NPC213749

Ingredient ID: NPC212819

Ingredient ID: NPC209970

Ingredient ID: NPC205959

Ingredient ID: NPC205522

Ingredient ID: NPC202977

Ingredient ID: NPC201547

Ingredient ID: NPC201057

Ingredient ID: NPC196832

Ingredient ID: NPC196439

Ingredient ID: NPC191184

Ingredient ID: NPC190771

Ingredient ID: NPC188261

Ingredient ID: NPC18351

Ingredient ID: NPC182840

Ingredient ID: NPC18205

Ingredient ID: NPC179831

Ingredient ID: NPC179540

Ingredient ID: NPC17810

Ingredient ID: NPC177148

Ingredient ID: NPC176819

Ingredient ID: NPC176775

Ingredient ID: NPC174360

Ingredient ID: NPC173695

Ingredient ID: NPC173295

Ingredient ID: NPC169407

Ingredient ID: NPC168855

Ingredient ID: NPC168602

Ingredient ID: NPC167815

Ingredient ID: NPC167010

Ingredient ID: NPC165651

Ingredient ID: NPC164964

Ingredient ID: NPC164487

Ingredient ID: NPC163556

Ingredient ID: NPC162050

Ingredient ID: NPC160961

Ingredient ID: NPC158824

Ingredient ID: NPC154480

Ingredient ID: NPC154176

Ingredient ID: NPC149184

Ingredient ID: NPC147723

Ingredient ID: NPC146165

Ingredient ID: NPC145379

Ingredient ID: NPC142860

Ingredient ID: NPC142366

Ingredient ID: NPC13933

Ingredient ID: NPC138932

Ingredient ID: NPC138867

Ingredient ID: NPC138397

Ingredient ID: NPC138360

Ingredient ID: NPC132428

Ingredient ID: NPC129680

Ingredient ID: NPC128726

Ingredient ID: NPC12664

Ingredient ID: NPC12509

Ingredient ID: NPC120253

Ingredient ID: NPC120163

Ingredient ID: NPC116994

Ingredient ID: NPC116502

Ingredient ID: NPC116315

Ingredient ID: NPC116260

Ingredient ID: NPC110639

Ingredient ID: NPC108663

Ingredient ID: NPC104323

Ingredient ID: NPC103711

Ingredient ID: NPC103213

Ingredient ID: NPC10286

Ingredient ID: NPC101294

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Target Type: Individual Protein of Homo sapiens
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.

Detailed Information of Target Proteins

Target Type Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Drug Transporter ATP-binding cassette ABCB1 P-glycoprotein 1 P08183 CHEMBL4302
Cytochrome P450 Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Therapeutic Target Enzyme AKR1C3 Aldo-keto-reductase family 1 member C3 P42330 CHEMBL4681
Therapeutic Target Fatty acid binding protein family FABP5 Fatty acid binding protein epidermal Q01469 CHEMBL3674
Therapeutic Target Fatty acid binding protein family FABP4 Fatty acid binding protein adipocyte P15090 CHEMBL2083
Therapeutic Target Lyase CA9 Carbonic anhydrase IX Q16790 CHEMBL3594
Therapeutic Target Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Therapeutic Target Nuclear hormone receptor subfamily 1 THRB Thyroid hormone receptor beta-1 P10828 CHEMBL1947
Therapeutic Target Nuclear hormone receptor subfamily 1 PPARA Peroxisome proliferator-activated receptor alpha Q07869 CHEMBL239
Therapeutic Target Oxidoreductase ALDH1A1 Aldehyde dehydrogenase 1A1 P00352 CHEMBL3577
Therapeutic Target Oxidoreductase ALOX15 Arachidonate 15-lipoxygenase P16050 CHEMBL2903
Therapeutic Target Peptide receptor (family A GPCR) TSHR Thyroid stimulating hormone receptor P16473 CHEMBL1963
Drug Transporter SLC superfamily of solute carriers SLCO1B1 Solute carrier organic anion transporter family member 1B1 Q9Y6L6 CHEMBL1697668
Therapeutic Target Small molecule receptor (family A GPCR) FFAR1 Free fatty acid receptor 1 O14842 CHEMBL4422
Therapeutic Target Small molecule receptor (family A GPCR) FFAR4 G-protein coupled receptor 120 Q5NUL3 CHEMBL5339
Therapeutic Target Structural protein LMNA Prelamin-A/C P02545 CHEMBL1293235
Therapeutic Target Transcription factor HIF1A Hypoxia-inducible factor 1 alpha Q16665 CHEMBL4261
Clinical Trials Summary
Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type Number of clinical trials
NP level25
Clinical trial details
NCT ID Title Condition Form in clinical use Associated by plant or compound
NCT00000152 Randomized Trial of Beta-Carotene and Macular Degeneration macular degeneration Beta Carotene (NPC17810) NP level
NCT00000161 Randomized Trials of Vitamin Supplements and Eye Disease cataract;macular degeneration Beta Carotene (NPC17810) NP level
NCT00000541 Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) myocardial infarction;Myocardial Ischemia Beta Carotene (NPC17810) NP level
NCT05232409 Determine Safety & Recommended Phase 2 Dosing of Zeaxanthin Alone or in Combination w/Pembrolizumab in Patients With Metastatic Cancer cancer (1R)-4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4R)-4-Hydroxy-2,6,6-Trimethylcyclohexen-1-Yl]-3,7,12,16-Tetramethyloctadeca-1,3,5,7,9,11,13,15,17-Nonaenyl]-3,5,5-Trimethylcyclohex-3-En-1-Ol (NPC45782) NP level
NCT04392622 d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma xerostomia Limonene (NPC76145) NP level
NCT01792310 A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours glioma Oleic Acid (NPC261831) NP level
NCT00951158 A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors neoplasm Linoleic Acid (NPC85813) NP level
NCT02063802 Metformin vs Conjugated Linoleic Acid and an Intervention Program With Healthy Habits in Obese Children obesity Linoleic Acid (NPC85813) NP level
NCT00885599 Efficacy of a Naturally-derived Mouthrinse for Gingival Inflammation gingivitis Thymol (NPC259512) NP level
NCT00908791 Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue breast cancer Linoleic Acid (NPC85813) NP level
NCT03959592 Macular Pigment and Visual Performance in Glaucoma Patients glaucoma (1R)-4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4R)-4-Hydroxy-2,6,6-Trimethylcyclohexen-1-Yl]-3,7,12,16-Tetramethyloctadeca-1,3,5,7,9,11,13,15,17-Nonaenyl]-3,5,5-Trimethylcyclohex-3-En-1-Ol (NPC45782) NP level
NCT00001986 1-Octanol to Treat Essential Tremor essential tremor Octanol (NPC163556) NP level
NCT01661764 Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention colorectal adenoma Oleic Acid (NPC261831) NP level
NCT02624843 Bioequivalence Study for Benzyl Alcohol Lotion 5%. lice infestation Benzyl Alcohol (NPC66655) NP level
NCT00275418 Beta Carotene From Natural Source for Patients With Non-Active Crohn's Disease Crohn's disease Beta Carotene (NPC17810) NP level
NCT00607945 Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus type 2 diabetes mellitus Linoleic Acid (NPC85813) NP level
NCT00102596 Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor essential tremor Octanol (NPC163556) NP level
NCT00330096 Effects of Hesperidin on Bone Mineral Density and Bone Metabolism of Postmenopausal Women osteoporosis Hesperidin (NPC79056) NP level
NCT00080366 Octanol to Treat Essential Tremor essential tremor Octanol (NPC163556) NP level
NCT00029679 Borage Oil and Ginkgo Biloba (EGb 761) in Asthma asthma Linoleic Acid (NPC85813) NP level
NCT00638196 Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS multiple sclerosis Oleic Acid (NPC261831) NP level
NCT04853082 Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution Hepatic steatosis Limonene (NPC76145) NP level
NCT00204932 Effects of CLA Supplements on Body Weight and Fat Oxidation obesity Linoleic Acid (NPC85813) NP level
NCT00016679 1-Octanol to Treat Essential Tremor essential tremor Octanol (NPC163556) NP level
NCT01637948 Controlled Clinical Trial of Traditional Chinese Medicine Mouthrinse gingivitis Thymol (NPC259512) NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

 How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
 ❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant
Association Type & Detailed Evidence
Hepatocellular carcinoma of liver
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.02
 CA12,CA9,FABP4,OR51E2,FABP5,AKR1C3,CA12,AKR1C3,CA9
Other specified malignant neoplasms of kidney, except renal pelvis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C90.Y
 CA9,FFAR4,FABP5,CA9,FFAR4,OR51E2,FABP5,TSHR
Mesothelioma of pleura
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C26.0
 FFAR1,CA12,CA9,FFAR4,OR51E2,ALOX15,ABCB1,LMNA
Carcinosarcoma of uterus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.43
 FFAR1,CA9,FFAR4,FABP5,ALOX15,NR1I2,TSHR
Squamous cell carcinoma of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.2
 CA12,CA9,OR51E2,AKR1C3,TSHR,SLCO1B1
Adenocarcinoma of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.0
 CA12,CA9,NR1I2,AKR1C3,TSHR,SLCO1B1
Germ cell tumour of testis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C80.2
 FABP3,CA12,FABP5,HIF1A,THRB,SLCO1B1
Malignant neoplasms of adrenal gland
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D11
 FABP3,FFAR1,CA12,CA9,OR51E2,FABP5
Solid tumour/cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00-2F9Z
 ABCB1,CA9,HIF1A,CA12,PPARA
Malignant neoplasms of biliary tract, distal bile duct
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C15
 CA9,OR51E2,FABP5,HIF1A,LMNA
Hepatoblastoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.01
 FABP3,CA12,FABP4,OR51E2,FABP5
Glioblastoma of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.00
 CA12,CA9,FABP5,TSHR,LMNA
Essential tremor or related tremors
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A04.1
 NCT00102596,NCT00001986,NCT00080366,NCT00016679
Malignant neoplasm metastasis in lymph nodes of head, face or neck
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D60.0
 CA9,FABP4,AKR1C3,SLCO1B1
Melanoma of skin
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C30
 FABP3,FFAR1,NR1I2,ALDH1A1
Adenocarcinoma of prostate
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C82.0
 OR51E2,FABP5,ALOX15,SLCO1B1
Malignant neoplasms of thymus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C27
 CA9,FFAR4,FABP5,ALOX15
Breast cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C60-2C6Y
 CA12,CA9
 NCT00908791
Type 2 diabetes mellitus
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A11
 FFAR1,PPARA
 NCT00607945
Other specified malignant neoplasms of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.Y
 CA12,CA9,AKR1C3
Urothelial carcinoma of bladder
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94.2
 CA9,CYP1A2,SLCO1B1
Cytomegaloviral disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D82
 ALOX15,THRB,ABCB1
Chikungunya virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D40
 FFAR1,HIF1A,LMNA
Mature T-cell lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A90
 CA9,HIF1A
Hypo-thyroidism
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A00
 TSHR,THRB
Non-alcoholic fatty liver disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB92
 PPARA
 FABP4
Acute diabete complication
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A2Y
 FFAR1,PPARA
Inborn lipid metabolism error
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C52
 PPARA,THRB
Hyper-lipoproteinaemia
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C80
 THRB,PPARA
Bacterial infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A00-1C4Z
 ABCB1,CA12
Obesity
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5B80-5B81
 NCT00204932,NCT02063802
Macular degeneration
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B75
 NCT00000152,NCT00000161
Gingival diseases
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA0B
 NCT00885599,NCT01637948
Pheochromocytoma
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH3854
 OR51E2,FABP5
Adenocarcinoma of stomach
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B72.0
 ALOX15,SLCO1B1
Other specified malignant neoplasms ofcolon
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90.Y
 CA9,SLCO1B1
Superficial ovarian endometriosis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA10.B4
 FABP3,LMNA
Malignant neoplasms of oesophagus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B70
 ALOX15,SLCO1B1
Malignant neoplasms of thyroid gland, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D10.Z
 CA12,FFAR1
Malignant neoplasms of corpus uteri, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.Z
 CA9,ALOX15
Invasive carcinoma of breast
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C61
 CA12,CA9
Renal cell carcinoma, chromophobe type
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH6153
 CA12,CYP1A2
Carpal tunnel syndrome
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C10.0
 FFAR4,OR51E2
Diffuse large B-cell lymphomas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A81
 FABP3,FFAR1,PPARA,CA12,CA9,FABP4,OR51E2,FABP5,NR1I2,THRB,ALDH1A1,TSHR,LMNA
Serous cystadenoma,borderline malignancy of ovary
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C73.4
 FABP3,CA12,CA9,CYP1A2,FFAR4,FABP5,ALOX15,NR1I2,THRB,TSHR
Adenocarcinoma of pancreas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10.0
 FABP3,ABCB1,CA9,FFAR4,OR51E2,HIF1A,ALOX15,NR1I2,AKR1C3,LMNA
Gout
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA25
 PPARA
Female pelvic pain
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA34
 AKR1C3
Dyslipidemia
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C80-5C81
 PPARA
Thyroid cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D10
 TSHR
Substance abuse
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6C40
 ALDH1A1
Lung cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25
 ABCB1
Pulmonary hypertension
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BB01
 HIF1A
Cardiovascular disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA00-BE2Z
 PPARA
Seborrhoeic dermatitis
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA81
 CA12
Diabetes mellitus, type unspecified
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A14
 PPARA
Idiopathic interstitial pneumonitis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CB03
 FFAR1
Brain cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00
 HIF1A
Prostate cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C82
 AKR1C3
Hyperlipidemia
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C80
 PPARA
Renal cell carcinoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C90
 CA9
Adrenomedullary hyperfunction
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A75
 HIF1A
Other specified non-alcoholic fatty liver disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB92.Y
 NCT04853082
Crohn disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD70
 NCT00275418
Myocardial infarction
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA41-BA43
 NCT00000541
Glioma, malignant
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH4RQ3
 NCT01792310
Cataract
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B10
 NCT00000161
Pediculosis of unspecified site or type
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1G00.Z
 NCT02624843
Multiple sclerosis
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A40
 NCT00638196
Neoplasms
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 02
 NCT00951158
Glaucoma
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9C61
 NCT03959592
Xerostomia
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA02.1
 NCT04392622
Colorectal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B91
 NCT01661764
Asthma
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA23
 NCT00029679
Unspecified malignant neoplasms of unspecified sites
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D4Z
 NCT05232409
Osteoporosis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FB83.1
 NCT00330096
Ischaemic heart diseases, unspecified
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA6Z
 NCT00000541
Coeliac disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA95
 TSHR
Myelodysplastic syndromes, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A3Z
 TSHR
Osteoarthritis, unspecified
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA0Z
 CA12
Dengue fever, unspecified
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D2Z
 NR1I2
Psoriasis
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA90
 FABP5
Leishmaniasis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F54
 TSHR
Malignant neoplasms of bladder
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94
 FABP4
Systemic sclerosis
Disease Category: 04.Diseases of the immune system
Disease ICD-11 Code: 4A42
 FABP4
Chronic rhinosinusitis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA0A
 CA9
Systemic lupus erythematosus
Disease Category: 04.Diseases of the immune system
Disease ICD-11 Code: 4A40.0
 FFAR1
Malignant neoplasms of stomach
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B72
 FABP4
Polycystic ovary syndrome
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A80.1
 FFAR4
Parkinson disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A00.0
 ALDH1A1
Human immunodeficiency virus disease without mention of tuberculosis or malaria
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1C62
 FFAR1
Malignant neoplasm of pancreas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10
 FABP4
Gliomas of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.0
 AKR1C3

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network 
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Plant Ingredients  
3. Collective Molecular Proteins  
4. Collective Enriched Activities  
5. Plant molecular targets overlapping with DEGs  
6. Associated clinical trials  
7. Associated Human Diseases  
>> Targets derived from weak experimental activities
About Us

The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD) and School of Pharmacy, Fudan University.

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Principle Investigator:
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Prof. Zeng Xian
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Developer & Maintainer:
Ph.D. Student Dongyue Hou
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Mr. Hanbo Lin
hblin19@fudan.edu.cn
Ms. Yuhan Feng
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