Ingredient ID: NPC99643
Ingredient ID: NPC96361
Ingredient ID: NPC95412
Ingredient ID: NPC94454
Ingredient ID: NPC93746
Ingredient ID: NPC92778
Ingredient ID: NPC90534
Ingredient ID: NPC85728
Ingredient ID: NPC83241
Ingredient ID: NPC74306
Ingredient ID: NPC73436
Ingredient ID: NPC72678
Ingredient ID: NPC70754
Ingredient ID: NPC63458
Ingredient ID: NPC60063
Ingredient ID: NPC55066
Ingredient ID: NPC46828
Ingredient ID: NPC44742
Ingredient ID: NPC37825
Ingredient ID: NPC33509
Ingredient ID: NPC311043
Ingredient ID: NPC305034
Ingredient ID: NPC304246
Ingredient ID: NPC264763
Ingredient ID: NPC254100
Ingredient ID: NPC2496
Ingredient ID: NPC248128
Ingredient ID: NPC247686
Ingredient ID: NPC242417
Ingredient ID: NPC239913
Ingredient ID: NPC222151
Ingredient ID: NPC216908
Ingredient ID: NPC214721
Ingredient ID: NPC208740
Ingredient ID: NPC198561
Ingredient ID: NPC194414
Ingredient ID: NPC187488
Ingredient ID: NPC181610
Ingredient ID: NPC179438
Ingredient ID: NPC174486
Ingredient ID: NPC171327
Ingredient ID: NPC17066
Ingredient ID: NPC169656
Ingredient ID: NPC166575
Ingredient ID: NPC154662
Ingredient ID: NPC138686
Ingredient ID: NPC137453
Ingredient ID: NPC13648
Ingredient ID: NPC136181
Ingredient ID: NPC124370
Ingredient ID: NPC124173
Ingredient ID: NPC105451
Ingredient ID: NPC102149
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Hydrolase | ADA | Adenosine deaminase | P00813 | CHEMBL1910 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 31 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT01352312 | Combination of Pentostatin, Bendamustine and Ofatumumab for Treatment of Chronic Lymphocytic Leukemia and Lymphoma | chronic lymphocytic leukemia | Pentostatin (NPC74306) | NP level |
NCT00049413 | Combination Chemotherapy and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia or Lymphocytic Lymphoma | leukemia;lymphoma | Pentostatin (NPC74306) | NP level |
NCT00669318 | Pentostatin, Alemtuzumab, and Rituximab in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma | leukemia;lymphoma | Pentostatin (NPC74306) | NP level |
NCT00003658 | Pentostatin, Cyclophosphamide, and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia or Other B-cell Cancers | leukemia;lymphoma | Pentostatin (NPC74306) | NP level |
NCT00074035 | Pentostatin in Treating Patients With Refractory Chronic Graft-Versus-Host Disease | graft versus host disease | Pentostatin (NPC74306) | NP level |
NCT00402714 | A Trial of Extracorporeal Photopheresis, Pentostatin, and Total Body Irradiation in Patients Undergoing Reduced Intensity Allogeneic Stem Cell Transplantation for the Treatment of Malignancies | cancer | Pentostatin (NPC74306) | NP level |
NCT03112603 | A Study of Ruxolitinib vs Best Available Therapy (BAT) in Patients With Steroid-refractory Chronic Graft vs. Host Disease (GvHD) After Bone Marrow Transplantation (REACH3) | graft versus host disease | Pentostatin (NPC74306) | NP level |
NCT00709215 | Study of Cordycepin Plus Pentostatin in Patients With Refractory TdT-Positive Leukemia | leukemia | Pentostatin (NPC74306) | NP level |
NCT00254163 | Fludarabine, Cyclophosphamide, and Rituximab Versus Pentostatin, Cyclophosphamide, and Rituximab in Previously Untreated or Treated B-Cell Chronic Lymphocytic Leukemia Patients | chronic lymphocytic leukemia | Pentostatin (NPC74306) | NP level |
NCT01059786 | Randomized Phase II Trial of Rituximab With Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell Leukemia | hairy cell leukemia | Pentostatin (NPC74306) | NP level |
NCT00201786 | Phase II Trial of Pentostatin in Steroid Refractory Acute Graft Versus Host Disease | graft versus host disease | Pentostatin (NPC74306) | NP level |
NCT00006968 | Pentostatin Followed by Peripheral Stem Cell Transplantation in Treating Patients With Advanced Kidney Cancer | kidney cancer | Pentostatin (NPC74306) | NP level |
NCT00506922 | Phase I/II Study of Pentostatin Combined With Tacrolimus and Mini-Methotrexate for GVHD Prevention After MUD BMT | leukemia;lymphoma | Pentostatin (NPC74306) | NP level |
NCT00546377 | Pentostatin, Cyclophosphamide, Rituximab, and Mitoxantrone in Treating Patients With Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Cancer | leukemia;lymphoma | Pentostatin (NPC74306) | NP level |
NCT00496340 | Phase II Trial of Pentostatin and Targeted Busulfan | cancer | Pentostatin (NPC74306) | NP level |
NCT01681563 | Trial of Pentostatin Plus Cyclophosphamide With Ofatumumab (PCO) in Older Patients With Chronic Lymphocytic Leukemia | chronic lymphocytic leukemia | Pentostatin (NPC74306) | NP level |
NCT00496873 | Evaluation of the Safety and Efficacy of Nipent, Cytoxan, and Rituxan | lymphoma | Pentostatin (NPC74306) | NP level |
NCT01024010 | Ofatumumab, Pentostatin, and Cyclophosphamide in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma | chronic lymphocytic leukemia | Pentostatin (NPC74306) | NP level |
NCT03077542 | Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease | sickle cell anemia | Pentostatin (NPC74306) | NP level |
NCT00224874 | Treatment for Acute Graft-Versus-Host Disease (BMT CTN 0302) | graft versus host disease | Pentostatin (NPC74306) | NP level |
NCT00074282 | Pentostatin, Cyclophosphamide, and Rituximab Followed By Campath-1H in Patients With Relapsed or Refractory B-Cell CLL | leukemia | Pentostatin (NPC74306) | NP level |
NCT00541034 | Pentostatin, Cyclophosphamide, and Rituximab in Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia | leukemia;lymphoma | Pentostatin (NPC74306) | NP level |
NCT00816595 | Pentostatin, Cyclophosphamide, and Rituximab With or Without Bevacizumab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma | leukemia;lymphoma | Pentostatin (NPC74306) | NP level |
NCT00453193 | Alemtuzumab and Pentostatin In T-cell Neoplasms | leukemia;lymphoma | Pentostatin (NPC74306) | NP level |
NCT00144430 | Pentostatin for High Risk and Refractory Chronic Graft Versus Host Disease in Children | graft versus host disease | Pentostatin (NPC74306) | NP level |
NCT00026351 | Pentostatin and Rituximab in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia | leukemia;lymphoma | Pentostatin (NPC74306) | NP level |
NCT00927797 | Interventional Study on Pentostatin, Cyclophosphamide and Rituximab in Indolent B-Cell Non-Hodgkin-Lymphoma (B-NHL) | chronic lymphocytic leukemia | Pentostatin (NPC74306) | NP level |
NCT00057954 | Reduced-Intensity Regimen Before Allogeneic Transplant for Patients With Relapsed Non-Hodgkin's or Hodgkin's Lymphoma | lymphoma | Pentostatin (NPC74306) | NP level |
NCT00032773 | Dose-finding Study Using Pentostatin for Injection in the Treatment of Steroid-refractory aGvHD | acute graft vs. host disease | Pentostatin (NPC74306) | NP level |
NCT00602836 | Rituximab, Pentostatin, Cyclophosphamide, and Lenalidomide in Treating Patients With Previously Untreated B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma | leukemia;lymphoma | Pentostatin (NPC74306) | NP level |
NCT00201721 | Pentostatin, and Rituximab With and Without Cyclophosphamide for Previously Untreated B-Chronic Lymphocytic Leukemia | chronic lymphocytic leukemia | Pentostatin (NPC74306) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Graft-versus-host diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4B24 |
NCT00074035,NCT03112603,NCT00144430,NCT00032773,NCT00224874,NCT00201786
|
Chronic lymphocytic leukaemia or small lymphocytic lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82.0 |
NCT00254163,NCT01681563,NCT01024010,NCT00201721,NCT01352312,NCT00927797
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
MAPK1,BCL2
|
Adaptive immunity immunodeficiencyDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01 |
ADA,ADA
|
Mature B-cell leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82 |
BCL2,ADA
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
ADA,BCL2
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
BCL2,MAPK1
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
MAPK1,BCL2
|
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT00496340,NCT00402714
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
ADA,BCL2
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
MAPK1,ADA
|
LeukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60-2B33 |
NCT00602836,NCT00816595,NCT00506922,NCT00541034,NCT00709215,NCT00669318,NCT00003658,NCT00074282,NCT00453193,NCT00546377,NCT00026351,NCT00049413
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
NCT00546377,NCT00003658,NCT00506922,NCT00669318,NCT00057954,NCT00453193,NCT00026351,NCT00049413,NCT00816595,NCT00541034,NCT00496873,NCT00602836
|
Mature B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A85 |
BCL2
|
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
BCL2
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
BCL2
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
BCL2
|
Ovarian dysfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80 |
BCL2
|
Chronic myelomonocytic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A40 |
BCL2
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
BCL2
|
BCR-ABL1-negative chronic myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A41 |
BCL2
|
Follicular lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A80 |
BCL2
|
Motor neuron diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60 |
BCL2
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
BCL2
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
ADA
|
Arteries/arterioles disorderDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD52 |
MAPK1
|
Diffuse large B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
BCL2
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
BCL2
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
BCL2
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
BCL2
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
BCL2
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
BCL2
|
Hairy cell leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH5J10 |
NCT01059786
|
Malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
NCT00006968
|
Sickle-cell disorderDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A51 |
NCT03077542
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
ADA
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
ADA
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
BCL2
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
BCL2
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
ADA
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
ADA
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
ADA
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
ADA
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
BCL2
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
ADA
|