Collective Molecular Activities of the Plant: Ageratum Conyzoides
Plant ID: NPO23234
Plant Latin Name: Ageratum Conyzoides
Taxonomy Genus: Ageratum
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
68299
Plant-of-the-World-Online:
n.a.
Country/Region:
Ghana; Tanzania; Indonesia; India; Malaysia; Rwanda; China; Vietnam; Thailand; Kenya; Nigeria; PhilippinesTraditional Medicine System:
Indian Folk; TCM; Ayurveda; SiddhaMedicinal Functions:
Antiinflammatory; Lithontripic; Skin; Styptic; Vulnerary
Ghana; Philippines; Indonesia; India; Malaysia; Rwanda; China; Vietnam; Thailand; Kenya; Nigeria; Tanzania
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
24 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
22 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
10 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC60288
Ingredient ID: NPC57429
Ingredient ID: NPC49103
Ingredient ID: NPC43728
Ingredient ID: NPC328788
Ingredient ID: NPC302408
Ingredient ID: NPC292996
Ingredient ID: NPC258130
Ingredient ID: NPC254474
Ingredient ID: NPC231738
Ingredient ID: NPC222515
Ingredient ID: NPC215932
Ingredient ID: NPC209054
Ingredient ID: NPC202600
Ingredient ID: NPC196776
Ingredient ID: NPC185755
Ingredient ID: NPC18188
Ingredient ID: NPC174246
Ingredient ID: NPC16157
Ingredient ID: NPC158934
Ingredient ID: NPC152451
Ingredient ID: NPC138925
Ingredient ID: NPC11433
Ingredient ID: NPC106551
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Drug Transporter | ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | GABA-A receptor | GABRR1 | GABA receptor rho-1 subunit | P24046 | CHEMBL3561 |
| Therapeutic Target | Protein methyltransferase | KMT2A | Histone-lysine N-methyltransferase MLL | Q03164 | CHEMBL1293299 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 16 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00573313 | Effects of SAMe in Patients With Alcoholic Liver Disease | liver disease | Methionine (NPC152451) | NP level |
| NCT02035501 | Treatment of TNNT1-Myopathy With L-Tyrosine. | nemaline myopathy | Tyrosine (NPC106551) | NP level |
| NCT00302289 | B181: Stimulation of Thermogenesis by Bio-Active Food Ingredients | obesity | Tyrosine (NPC106551) | NP level |
| NCT03887169 | Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene. | pulmonary alveolar proteinosis | Methionine (NPC152451) | NP level |
| NCT02002130 | The Use of Glutamic Acid Decarboxylase (GAD) and Gamma-Amino Butyric Acid (GABA) in the Treatment of Type I Diabetes | type 1 diabetes mellitus | Gamma-Aminobutyric Acid (NPC18188) | NP level |
| NCT01140646 | Evaluation of SAMe for Hot Flashes | Hot flashes | Methionine (NPC152451) | NP level |
| NCT01871766 | Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified Chemotherapy | rhabdomyosarcoma | Methionine (NPC152451) | NP level |
| NCT02125786 | A Trial of Surgery and Fractionated Re-Irradiation for Recurrent Ependymoma | ependymoma | Methionine (NPC152451) | NP level |
| NCT00108589 | S-Adenosylmethionine Therapy for Non-Alcoholic Steatohepatitis | Hepatitis | Methionine (NPC152451) | NP level |
| NCT00694564 | Evaluation of S-adenosyl Methionine (SAM-e) for Recurrent Abdominal Pain in Children | Abdominal pain | Methionine (NPC152451) | NP level |
| NCT01345474 | Phase 3 Clinical Trial: D-methionine to Reduce Noise-Induced Hearing Loss (NIHL) | noise-induced hearing loss | Methionine (NPC152451) | NP level |
| NCT02586285 | Effect of S-Adenosyl Methionine Treatment on Recurrence After Curative Resection of Hepatocellular Carcinoma | hepatocellular carcinoma | Methionine (NPC152451) | NP level |
| NCT02903355 | Phase 3 Clinical Trial: D-methionine to Reduce Noise-Induced Hearing Loss (NIHL) | noise-induced hearing loss | Methionine (NPC152451) | NP level |
| NCT01419067 | A Phase II Trial of Limited Surgery and Proton Therapy for Craniopharyngioma or Observation After Radical Resection | Craniopharyngioma | Methionine (NPC152451) | NP level |
| NCT00475176 | S-Adenosyl Methionine (SAMe) to Treat Patients With Chronic Hepatitis C | chronic hepatitis C virus infection | Methionine (NPC152451) | NP level |
| NCT03418935 | Remaxol® in Mechanical Jaundice of Non-malignant Origin | obstructive jaundice | Methionine (NPC152451) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
BLM,GABBR2,SLC6A11,GABRA3,GABRA2,GABRA3,SLC6A11,GABRA2,GABBR2
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
GABRA5,GABRA3,GABRB2,GABBR2,GABRA2,GABRG2,SLC6A11
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ABCB1,LMNA,BLM,GABBR2,GABRR1,GABRA3,GABRA2
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
SLC6A12,GABBR2,GABRA5,SLC6A11,GABRR1,GABRA3
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
BLM,GABRA5,SLC6A11,GABRR1,GABRA3,GABRA2
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
ABCB1,LMNA,GABRA5,SLC6A11,GABRA3,GABRA2
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
BLM,GABBR2,GABRA5,SLC6A11,GABRR1,GABRA3
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
GABBR2,GABRA5,GABRR1,GABRA3,GABRA2
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
BLM,GABRA5,SLC6A11,GABRR1,GABRA3
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
BLM,GABBR2,GABRA5,SLC6A11,GABRA3
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA,BLM,GABBR2,SLC6A11
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
BLM,SLC6A11,GABRR1,GABRA3
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
SLC6A12,GABRA5,GABRR1,GABRA2
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
BLM,GABBR2,GABRA5,GABRA3
|
Intentional self-harmDisease Category: 23.External causes of morbidity or mortalityDisease ICD-11 Code: PC91 |
GABRA2,GABRA5,GABRA3
|
Epilepsy/seizureDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A61-8A6Z |
GABRB2,GABBR2,GABRG2
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
BLM,GABRR1,GABRA3
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ABCB1,SLC6A11,SLC6A12
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
GABRA5,GABRR1,GABRA3
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA,BLM,GABRR1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
GABRA5,BLM,GABRA3
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
GABRA5,GABBR2
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
ABCB1,GABBR2
|
Tonus and reflex abnormalityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB47 |
GABRG2,GABRB2
|
Noise effects on inner earDisease Category: 10.Diseases of the ear or mastoid processDisease ICD-11 Code: AB37 |
NCT01345474,NCT02903355
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
BLM,SLC6A12
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
LMNA,BLM
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
GABBR2,GABBR2
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
SLC6A11,GABRA3
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
GABRA5,LMNA
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
BLM,GABRA3
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
BLM,GABBR2
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
GABRA6,GABBR2
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
GABRA2,GABBR2
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
GABRR1,BLM
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
SLC6A11,LMNA
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
ABCB1
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
GABBR2
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
GABBR2
|
Sleep-wake disorderDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7B2Z |
GABRA3
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
GABRA3
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
GABRB2
|
Fragile X chromosomeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD55 |
GABBR2
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
GABBR2
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
ABCB1
|
Adaptive immunity immunodeficiencyDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01 |
GABRA5
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
GABRA5
|
Sex development malformative disorderDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD2A |
GABRA5
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
GABBR2
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
GABBR2
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
GABRA5
|
NarcolepsyDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A20 |
GABBR2
|
CraniopharyngiomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1AZ2 |
NCT01419067
|
Nemaline myopathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C72.00 |
NCT02035501
|
Hepatocellular carcinoma, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH4W48 |
NCT02586285
|
Liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB90-DB10Z |
NCT00573313
|
Obstruction of bile ductDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC10.02 |
NCT03418935
|
Ependymoma, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH1511 |
NCT02125786
|
Type1diabetesmellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A10 |
NCT02002130
|
Rhabdomyosarcoma, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH0GA1 |
NCT01871766
|
Pulmonary alveolar proteinosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB04.31 |
NCT03887169
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
NCT00302289
|
Acute viral hepatitisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50 |
NCT00108589
|
Flare or flashDisease Category: X.Extension CodesDisease ICD-11 Code: XE03F |
NCT01140646
|
Chronic hepatitis CDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E51.1 |
NCT00475176
|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
GABRA5
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
SLC6A12
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
GABBR2
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
SLC6A12
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
BLM
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
