CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Microtropis Japonica

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO22421
Plant Latin Name: Microtropis Japonica
Taxonomy Genus: Microtropis
Taxonomy Family: Celastraceae

Plant External Links:

NCBI TaxonomyDB: 1089418
Plant-of-the-World-Online: 162174-1

Used in Medicines

Unknown.

Geographical Distribution

Japan; Taiwan

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

57 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

17 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

30 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC93284

Ingredient ID: NPC85015

Ingredient ID: NPC83546

Ingredient ID: NPC79274

Ingredient ID: NPC75439

Ingredient ID: NPC67777

Ingredient ID: NPC51700

Ingredient ID: NPC50763

Ingredient ID: NPC474903

Ingredient ID: NPC473673

Ingredient ID: NPC46161

Ingredient ID: NPC46157

Ingredient ID: NPC43241

Ingredient ID: NPC41481

Ingredient ID: NPC39793

Ingredient ID: NPC3957

Ingredient ID: NPC303424

Ingredient ID: NPC300637

Ingredient ID: NPC298268

Ingredient ID: NPC291638

Ingredient ID: NPC285423

Ingredient ID: NPC280807

Ingredient ID: NPC274613

Ingredient ID: NPC27377

Ingredient ID: NPC265294

Ingredient ID: NPC264935

Ingredient ID: NPC258051

Ingredient ID: NPC240722

Ingredient ID: NPC239608

Ingredient ID: NPC238626

Ingredient ID: NPC237627

Ingredient ID: NPC23465

Ingredient ID: NPC234196

Ingredient ID: NPC230301

Ingredient ID: NPC229663

Ingredient ID: NPC228170

Ingredient ID: NPC222342

Ingredient ID: NPC206467

Ingredient ID: NPC203719

Ingredient ID: NPC195647

Ingredient ID: NPC191082

Ingredient ID: NPC191010

Ingredient ID: NPC185810

Ingredient ID: NPC177340

Ingredient ID: NPC164031

Ingredient ID: NPC162393

Ingredient ID: NPC147802

Ingredient ID: NPC147217

Ingredient ID: NPC145879

Ingredient ID: NPC141447

Ingredient ID: NPC139067

Ingredient ID: NPC118614

Ingredient ID: NPC111888

Ingredient ID: NPC110699

Ingredient ID: NPC110388

Ingredient ID: NPC108689

Ingredient ID: NPC106055

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Enzyme	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Therapeutic Target	Enzyme	CES1	Acyl coenzyme A:cholesterol acyltransferase	P23141	CHEMBL2265
Therapeutic Target	Histone deacetylase	HDAC9	Histone deacetylase 9	Q9UKV0	CHEMBL4145
Therapeutic Target	Histone deacetylase	HDAC10	Histone deacetylase 10	Q969S8	CHEMBL5103
Therapeutic Target	Histone deacetylase	HDAC11	Histone deacetylase 11	Q96DB2	CHEMBL3310
Therapeutic Target	Histone deacetylase	HDAC8	Histone deacetylase 8	Q9BY41	CHEMBL3192
Therapeutic Target	Histone deacetylase	HDAC4	Histone deacetylase 4	P56524	CHEMBL3524
Therapeutic Target	Histone deacetylase	HDAC3	Histone deacetylase 3	O15379	CHEMBL1829
Therapeutic Target	Histone deacetylase	HDAC6	Histone deacetylase 6	Q9UBN7	CHEMBL1865
Therapeutic Target	Histone deacetylase	HDAC2	Histone deacetylase 2	Q92769	CHEMBL1937
Therapeutic Target	Histone deacetylase	HDAC7	Histone deacetylase 7	Q8WUI4	CHEMBL2716
Therapeutic Target	Histone deacetylase	HDAC5	Histone deacetylase 5	Q9UQL6	CHEMBL2563
Therapeutic Target	Histone deacetylase	HDAC1	Histone deacetylase 1	Q13547	CHEMBL325
Therapeutic Target	Nuclear hormone receptor subfamily 1	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Therapeutic Target	Nuclear hormone receptor subfamily 1	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Therapeutic Target	Other nuclear protein	SF3B3	Splicing factor 3B subunit 3	Q15393	CHEMBL1250378
Therapeutic Target	Surface antigen	F3	Coagulation factor III	P13726	CHEMBL4081
Therapeutic Target	Transcription factor	RELA	Nuclear factor NF-kappa-B p65 subunit	Q04206	CHEMBL5533

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	5

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT03838926	Tolerability Study of Trichostatin A In Subjects With Relapsed or Refractory Hematologic Malignancies	cancer	Trichostatin (NPC280807)	NP level
NCT02337933	Effect of Ursolic Acid Administration on Insulin Sensitivity and Metabolic Syndrome	metabolic syndrome	Ursolic Acid (NPC51700)	NP level
NCT04403568	Testing the Synergism of Phytonutrients, Curcumin and Ursolic Acid, to Target Molecular Pathways in the Prostate	prostate cancer	Ursolic Acid (NPC51700)	NP level
NCT03216876	A Study Of Ursolic Acid For Primary Sclerosing Cholangitis	sclerosing cholangitis	Ursolic Acid (NPC51700)	NP level
NCT02468687	NMP in Relapsed / Refractory Myeloma	multiple myeloma	1-Methylpyrrolidin-2-One (NPC234196)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	HDAC9,TRIM24,HDAC2,HDAC8,SF3B3,F3,HDAC1,RECQL
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	F3,RORC,HDAC2,HDAC8,RELA,HDAC6,HDAC3
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	HDAC9,F2,HDAC2,HDAC8,HDAC1,HDAC3,HDAC7
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	HDAC9,HDAC4,F3,HDAC11,NCOR2,HDAC7
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	HDAC9,TRIM24,HDAC4,HDAC11,HDAC7
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	HDAC9,F2,HDAC1,RECQL,CES1
Mature T-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A90	HDAC3,HDAC2,HDAC1,HDAC1
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	HDAC9,HDAC5,HDAC11,RORC
Multiple sclerosis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A40	RORC,F2,RELA
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	F2,RELA,HDAC1
Multiple myeloma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A83	HDAC1,HDAC6 NCT02468687
Tetralogy of Fallot Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LA88.2	F2,RORC,F3
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	HDAC11,HDAC11,TRIM24
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	HDAC4,HDAC2,TRIM24
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	RELA,RORC
Muscular dystrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C70	HDAC1,RELA
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	HDAC1,RELA
Cerebral ischaemic stroke Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B11	HDAC1,F2
Bleeding disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA20-GA21	F2,F3
Metabolic disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C50-5D2Z	HDAC1 NCT02337933
Ischaemic/haemorrhagic stroke Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B20	HDAC1,F2
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	RORC,HDAC2
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	HDAC9,RORC
Irritable bowel syndrome Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD91	RELA
Renal cell carcinoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90	HDAC1
Coronary thrombosis Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA43	F2
Nutritional deficiency Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B50-5B71	F2
Diabetes mellitus, type unspecified Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A14	RELA
BCR-ABL1-negative chronic myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A41	HDAC1
Choreiform disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A01	RELA
Skin and skin-structure infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F28-1G0Z	RELA
Pancreatic cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10	F3
Angina pectoris Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA40	F2
Coagulation defect Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3B10	F2
Ataxic disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A03	HDAC1
Myocardial infarction Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA41-BA43	F2
Autoimmune disease Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40-4A45	RORC
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	HDAC1
Colorectal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B91	HDAC1
Diffuse large B-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	HDAC1
Sickle-cell disorder Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3A51	HDAC1
Cerebral ischaemia Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B1Z	HDAC1
Fungal infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F29-1F2F	RELA
Myeloproliferative neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A20	HDAC1
Chronic arterial occlusive disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD4Z	CES1
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	RELA
Mood disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A60-6E23	HDAC1
Acute/subacute hepatic failure Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB91	RELA
Lung cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25	RORC
Thrombosis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB61-GB90	F2
Hyper-lipoproteinaemia Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C80	CES1
Cardiovascular disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00-BE2Z	F2
Thrombocytopenia Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3B64	F2
Mycosis fungoides Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B01	HDAC1
Synthesis disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C52-5C59	CES1
Crohn disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD70	RORC
Intracranial injury Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: NA07	HDAC1
Acute respiratory distress syndrome Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB00	F3
Lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40	RELA
Liver cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12	HDAC1
Rheumatoid arthritis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA20	RELA
Thrombocytosis Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3B63	HDAC1
Indeterminate colitis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD72	RELA
Peroxisomal disease Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C57	CES1
Ovarian cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73	HDAC1
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	F2
Prostate cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82	NCT04403568
Unspecified malignant neoplasms of unspecified sites Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D4Z	NCT03838926
Primary sclerosing cholangitis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB96.2	NCT03216876
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	F2
Malignant neoplasm metastasis in lymph nodes of head, face or neck Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60.0	F2
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	F2
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	RECQL
Other specified malignant neoplasms ofcolon Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90.Y	F2
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	F2
Systemic lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40.0	F3
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	F2
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	F2
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	F3
Human immunodeficiency virus disease without mention of tuberculosis or malaria Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1C62	HDAC9
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	HDAC1

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Microtropis Japonica

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

57 All known Ingredients in Total

17 Ingredients with Acceptable Bioavailablity

30 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Diffuse large B-cell lymphomas

Solid tumour/cancer

Germ cell tumour of testis

Malignant neoplasms of biliary tract, distal bile duct

Hepatoblastoma

Adenocarcinoma of pancreas

Mature T-cell lymphoma

Pheochromocytoma

Multiple sclerosis

Type 2 diabetes mellitus

Multiple myeloma

Tetralogy of Fallot

Hepatocellular carcinoma of liver

Malignant neoplasms of thymus

Psoriasis

Muscular dystrophy

Acute myeloid leukaemia

Cerebral ischaemic stroke

Bleeding disorder

Metabolic disorder

Ischaemic/haemorrhagic stroke

Carcinosarcoma of uterus

Serous cystadenoma,borderline malignancy of ovary

Irritable bowel syndrome

Renal cell carcinoma

Coronary thrombosis

Nutritional deficiency

Diabetes mellitus, type unspecified

BCR-ABL1-negative chronic myeloid leukaemia

Choreiform disorder

Skin and skin-structure infection

Pancreatic cancer

Angina pectoris

Coagulation defect

Ataxic disorder

Myocardial infarction

Autoimmune disease

Breast cancer

Colorectal cancer

Diffuse large B-cell lymphoma

Sickle-cell disorder

Cerebral ischaemia

Fungal infection

Myeloproliferative neoplasm

Chronic arterial occlusive disease

Atopic eczema

Mood disorder

Acute/subacute hepatic failure

Lung cancer

Thrombosis

Hyper-lipoproteinaemia

Cardiovascular disease

Thrombocytopenia

Mycosis fungoides

Synthesis disorder

Crohn disease

Intracranial injury

Acute respiratory distress syndrome

Lupus erythematosus

Liver cancer

Rheumatoid arthritis

Thrombocytosis

Indeterminate colitis

Peroxisomal disease