Collective Molecular Activities of the Plant: Garcinia Dulcis
Country/Region:
Thailand; Indonesia; China; IndiaTraditional Medicine System:
Indian Folk; TCMAustralia; Myanmar; Philippines; Indonesia; India; Trinidad and Tobago; China; Thailand
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
41 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
21 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
21 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC91597
Ingredient ID: NPC90246
Ingredient ID: NPC8747
Ingredient ID: NPC8493
Ingredient ID: NPC80962
Ingredient ID: NPC74953
Ingredient ID: NPC63335
Ingredient ID: NPC61010
Ingredient ID: NPC48624
Ingredient ID: NPC40491
Ingredient ID: NPC37870
Ingredient ID: NPC33051
Ingredient ID: NPC32867
Ingredient ID: NPC306205
Ingredient ID: NPC303485
Ingredient ID: NPC301950
Ingredient ID: NPC301826
Ingredient ID: NPC283262
Ingredient ID: NPC275463
Ingredient ID: NPC262286
Ingredient ID: NPC256754
Ingredient ID: NPC252933
Ingredient ID: NPC251065
Ingredient ID: NPC228785
Ingredient ID: NPC214299
Ingredient ID: NPC20646
Ingredient ID: NPC204290
Ingredient ID: NPC191146
Ingredient ID: NPC189473
Ingredient ID: NPC181757
Ingredient ID: NPC17334
Ingredient ID: NPC171985
Ingredient ID: NPC170904
Ingredient ID: NPC169101
Ingredient ID: NPC166201
Ingredient ID: NPC162952
Ingredient ID: NPC150168
Ingredient ID: NPC146134
Ingredient ID: NPC14353
Ingredient ID: NPC132111
Ingredient ID: NPC131344
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
BACE1
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
NUDT1
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
NUDT1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
ALOX12,NUDT1
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
NUDT1
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
NUDT1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
NUDT1
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
ALOX12,NUDT1
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
NUDT1
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
BACE1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
