Collective Molecular Activities of the Plant: Fraxinus Angustifolia
Plant ID: NPO20677
Plant Latin Name: Fraxinus Angustifolia
Taxonomy Genus: Fraxinus
Taxonomy Family: Oleaceae
Plant External Links:
NCBI TaxonomyDB:
166594
Plant-of-the-World-Online:
n.a.
Country/Region:
Lebanon; PortugalTraditional Medicine System:
Lebanon; Portugal
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
49 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
11 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
10 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95512
Ingredient ID: NPC89325
Ingredient ID: NPC83137
Ingredient ID: NPC80776
Ingredient ID: NPC80670
Ingredient ID: NPC7855
Ingredient ID: NPC7599
Ingredient ID: NPC7479
Ingredient ID: NPC74097
Ingredient ID: NPC56325
Ingredient ID: NPC54726
Ingredient ID: NPC40733
Ingredient ID: NPC38579
Ingredient ID: NPC34393
Ingredient ID: NPC306169
Ingredient ID: NPC302025
Ingredient ID: NPC296734
Ingredient ID: NPC288986
Ingredient ID: NPC286134
Ingredient ID: NPC280486
Ingredient ID: NPC269192
Ingredient ID: NPC264553
Ingredient ID: NPC264495
Ingredient ID: NPC258770
Ingredient ID: NPC254324
Ingredient ID: NPC25252
Ingredient ID: NPC248944
Ingredient ID: NPC24106
Ingredient ID: NPC232037
Ingredient ID: NPC230301
Ingredient ID: NPC227260
Ingredient ID: NPC220847
Ingredient ID: NPC216515
Ingredient ID: NPC209912
Ingredient ID: NPC202827
Ingredient ID: NPC196884
Ingredient ID: NPC187154
Ingredient ID: NPC170094
Ingredient ID: NPC169055
Ingredient ID: NPC161035
Ingredient ID: NPC148347
Ingredient ID: NPC141769
Ingredient ID: NPC141427
Ingredient ID: NPC13475
Ingredient ID: NPC132731
Ingredient ID: NPC12910
Ingredient ID: NPC126142
Ingredient ID: NPC119831
Ingredient ID: NPC102504
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2,SLCO1B3,SLCO1B1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
F2,SLCO1B3
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
SLCO1B3,SLCO1B1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2,SLCO1B3,SLCO1B1
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
F2
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
F2
|
Coagulation defectDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B10 |
F2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
