Collective Molecular Activities of the Plant: Delphinium Virgatum
Plant ID: NPO20625
Plant Latin Name: Delphinium Virgatum
Taxonomy Genus: Delphinium
Taxonomy Family: Ranunculaceae
Plant External Links:
NCBI TaxonomyDB:
984885
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
56 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
23 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
29 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98777
Ingredient ID: NPC98583
Ingredient ID: NPC94583
Ingredient ID: NPC92117
Ingredient ID: NPC91409
Ingredient ID: NPC91239
Ingredient ID: NPC8651
Ingredient ID: NPC78946
Ingredient ID: NPC76128
Ingredient ID: NPC76112
Ingredient ID: NPC70622
Ingredient ID: NPC57380
Ingredient ID: NPC5029
Ingredient ID: NPC44260
Ingredient ID: NPC38851
Ingredient ID: NPC36959
Ingredient ID: NPC313047
Ingredient ID: NPC312929
Ingredient ID: NPC308738
Ingredient ID: NPC305843
Ingredient ID: NPC304452
Ingredient ID: NPC301384
Ingredient ID: NPC288089
Ingredient ID: NPC282923
Ingredient ID: NPC278329
Ingredient ID: NPC271385
Ingredient ID: NPC264145
Ingredient ID: NPC261147
Ingredient ID: NPC26080
Ingredient ID: NPC254847
Ingredient ID: NPC248949
Ingredient ID: NPC248668
Ingredient ID: NPC247364
Ingredient ID: NPC232189
Ingredient ID: NPC229036
Ingredient ID: NPC225710
Ingredient ID: NPC216752
Ingredient ID: NPC214165
Ingredient ID: NPC199875
Ingredient ID: NPC198440
Ingredient ID: NPC197087
Ingredient ID: NPC181448
Ingredient ID: NPC178851
Ingredient ID: NPC176740
Ingredient ID: NPC160512
Ingredient ID: NPC159106
Ingredient ID: NPC146973
Ingredient ID: NPC146837
Ingredient ID: NPC142811
Ingredient ID: NPC142063
Ingredient ID: NPC130315
Ingredient ID: NPC128792
Ingredient ID: NPC123953
Ingredient ID: NPC114746
Ingredient ID: NPC108455
Ingredient ID: NPC101649
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Therapeutic Target | Miscellaneous ion channel | BCL2 | Apoptosis regulator Bcl-2 | P10415 | CHEMBL4860 |
| Therapeutic Target | Oxidoreductase | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Therapeutic Target | Oxidoreductase | PGD | 6-phosphogluconate dehydrogenase | P52209 | CHEMBL3404 |
| Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Threonine protease | PSMB5 | Proteasome Macropain subunit MB1 | P28074 | CHEMBL4662 |
| Therapeutic Target | Threonine protease | PSMB1 | Proteasome component C5 | P20618 | CHEMBL4208 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 52 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00003170 | Glutamine in Preventing Acute Diarrhea in Patients With Pelvic Cancer | cancer | Glutamine (NPC197087) | NP level |
| NCT00003898 | Glutamine in Treating Side Effects in Children Who Are Undergoing Stem Cell Transplantation | neoplasm | Glutamine (NPC197087) | NP level |
| NCT00005775 | Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants | fetal growth restriction;premature birth;Sepsis | Glutamine (NPC197087) | NP level |
| NCT00006994 | S9908: Glutamine in Treating Mucositis Caused by Radiation Therapy in Patients With Newly Diagnosed Cancer of the Mouth or Throat | oral mucositis | Glutamine (NPC197087) | NP level |
| NCT00010634 | Complementary Naturopathic Medicine for Periodontitis | periodontitis | Glutamine (NPC197087) | NP level |
| NCT00016653 | Creatine and Glutamine in Steroid-Naive Duchenne Muscular Dystrophy | Duchenne muscular dystrophy | Glutamine (NPC197087) | NP level |
| NCT00018109 | A Multicenter Randomized Placebo-Controlled Double-Blind Study to Assess Efficacy and Safety of Glutamine and Creatine Monohydrate in Duchenne Muscular Dystrophy (DMD) | Duchenne muscular dystrophy | Glutamine (NPC197087) | NP level |
| NCT00125788 | L-Glutamine Therapy for Sickle Cell Anemia and Sickle ß0 Thalassemia | Thalassemia;sickle cell anemia | Glutamine (NPC197087) | NP level |
| NCT00131508 | Trial of Oral Glutamine in Patients With Sickle Cell Anemia | sickle cell anemia | Glutamine (NPC197087) | NP level |
| NCT00133406 | Long-term Impact and Intervention for Diarrhea in Brazil | diarrheal disease | Glutamine (NPC197087) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
BCL2
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
BLM,ACHE
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
BLM,FUT7,ACHE,PGD,LMNA
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
BLM
|
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT04634539
|
Adrenal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
ESR1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ACHE
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NCT04019769
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
