Ingredient ID: NPC9880
Ingredient ID: NPC95126
Ingredient ID: NPC88566
Ingredient ID: NPC72838
Ingredient ID: NPC44715
Ingredient ID: NPC3649
Ingredient ID: NPC32817
Ingredient ID: NPC311485
Ingredient ID: NPC293831
Ingredient ID: NPC273876
Ingredient ID: NPC273832
Ingredient ID: NPC273607
Ingredient ID: NPC272537
Ingredient ID: NPC256039
Ingredient ID: NPC241408
Ingredient ID: NPC223695
Ingredient ID: NPC21405
Ingredient ID: NPC209971
Ingredient ID: NPC208620
Ingredient ID: NPC208322
Ingredient ID: NPC19721
Ingredient ID: NPC190810
Ingredient ID: NPC181051
Ingredient ID: NPC179694
Ingredient ID: NPC174006
Ingredient ID: NPC155185
Ingredient ID: NPC151502
Ingredient ID: NPC149455
Ingredient ID: NPC141777
Ingredient ID: NPC138113
Ingredient ID: NPC126240
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Enzyme | KARS1 | Lysyl-tRNA synthetase | Q15046 | CHEMBL5575 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 2 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT03606694 | Effect of Dihydromirycetin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | (2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-Trihydroxyphenyl)-2,3-Dihydrochromen-4-One (NPC19721) | NP level |
NCT05432284 | Behavioral Pharmacology of THC and Beta-Myrcene | cannabis dependence | Myrcene (NPC138113) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
NCT03606694
|
Cannabis use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C41 |
NCT05432284
|