Mouthwash
Turkey; Italy; Kenya; Sudan; Mongolia; France; Ethiopia; Rwanda; Tanzania; Somalia; Ireland; Argentina; Norway; Uzbekistan; Belarus; Algeria; Cape Verde; China; Belgium; Germany; Kazakhstan; Djibouti; Spain; Ukraine; Eritrea; Netherlands; Libya; Denmark; Poland; Finland; United States; Morocco; Sweden; Japan; Switzerland; New Zealand; Russia; Bulgaria; Romania; Albania; Portugal; South Africa; Tunisia; Tajikistan; India; United Kingdom; Austria; Uganda; Greece; Hungary; Cyprus
Ingredient ID: NPC98098
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Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
Therapeutic Target | Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2B | Alpha-2b adrenergic receptor | P18089 | CHEMBL1942 |
Therapeutic Target | Small molecule receptor (family A GPCR) | P2RY14 | Purinergic receptor P2Y14 | Q15391 | CHEMBL4518 |
Therapeutic Target | Transcription factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
![]() | 170 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Ascorbate (NPC187770) | ![]() |
NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction;Myocardial Ischemia | Ascorbate (NPC187770) | ![]() |
NCT00000555 | Women's Angiographic Vitamin and Estrogen Trial (WAVE) | menopause;Myocardial Ischemia | Ascorbate (NPC187770) | ![]() |
NCT00000600 | Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-Up | carotid artery disease;cerebral atherosclerosis;heart disease | Ascorbate (NPC187770) | ![]() |
NCT00006021 | Arsenic Trioxide Plus Vitamin C in Treating Patients With Recurrent or Refractory Multiple Myeloma | multiple myeloma | Ascorbate (NPC187770) | ![]() |
NCT00067899 | Oxidative Stress and Vitamin E Requirements | nicotine dependence | Ascorbate (NPC187770) | ![]() |
NCT00085345 | Melphalan, Arsenic Trioxide, and Ascorbic Acid in Treating Patients With Relapsed or Refractory Multiple Myeloma | multiple myeloma | Ascorbate (NPC187770) | ![]() |
NCT00112879 | Arsenic Trioxide, Ascorbic Acid, Dexamethasone, and Thalidomide in Treating Patients With Multiple Myeloma | multiple myeloma | Ascorbate (NPC187770) | ![]() |
NCT00184054 | Trial of Arsenic Trioxide With Ascorbic Acid in the Treatment of Adult Non-Acute Promyelocytic Leukemia (APL) Acute Myelogenous Leukemia | acute myeloid leukemia | Ascorbate (NPC187770) | ![]() |
NCT00211562 | Adjunctive Supplementation of Antioxidants (Vitamins E + C) Plus Omega-3 Fatty Acids | schizophrenia | Ascorbate (NPC187770) | ![]() |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
NCT03522922 |
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53
NCT00184054,NCT00329498 |
Acute promyelocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1A50 |
NCT03624270
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04404387
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
TSHR
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
P2RY14
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NCT01080352
|
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT03697239,NCT03908333,NCT03410030
|
Adrenal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
ESR1
|