Collective Molecular Activities of the Plant: Clausena Excavata
Country/Region:
Thailand; Indonesia; IndiaTraditional Medicine System:
Australia; Bangladesh; Myanmar; Philippines; Indonesia; India; Cambodia; Seychelles; China; Vietnam; Laos; Thailand; Taiwan
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
68 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
58 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
40 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC92592
Ingredient ID: NPC92203
Ingredient ID: NPC91240
Ingredient ID: NPC87413
Ingredient ID: NPC86834
Ingredient ID: NPC83535
Ingredient ID: NPC77466
Ingredient ID: NPC76982
Ingredient ID: NPC73719
Ingredient ID: NPC71184
Ingredient ID: NPC66430
Ingredient ID: NPC51388
Ingredient ID: NPC48938
Ingredient ID: NPC481292
Ingredient ID: NPC481291
Ingredient ID: NPC481290
Ingredient ID: NPC481289
Ingredient ID: NPC481288
Ingredient ID: NPC481287
Ingredient ID: NPC481286
Ingredient ID: NPC481285
Ingredient ID: NPC481284
Ingredient ID: NPC46561
Ingredient ID: NPC40959
Ingredient ID: NPC39679
Ingredient ID: NPC39500
Ingredient ID: NPC37009
Ingredient ID: NPC310370
Ingredient ID: NPC310211
Ingredient ID: NPC305518
Ingredient ID: NPC304935
Ingredient ID: NPC303951
Ingredient ID: NPC302078
Ingredient ID: NPC293811
Ingredient ID: NPC293151
Ingredient ID: NPC29254
Ingredient ID: NPC27828
Ingredient ID: NPC274943
Ingredient ID: NPC265547
Ingredient ID: NPC247803
Ingredient ID: NPC24615
Ingredient ID: NPC23387
Ingredient ID: NPC231898
Ingredient ID: NPC229700
Ingredient ID: NPC218034
Ingredient ID: NPC212535
Ingredient ID: NPC211968
Ingredient ID: NPC210828
Ingredient ID: NPC206681
Ingredient ID: NPC206212
Ingredient ID: NPC20357
Ingredient ID: NPC193993
Ingredient ID: NPC187501
Ingredient ID: NPC18043
Ingredient ID: NPC179365
Ingredient ID: NPC174760
Ingredient ID: NPC169402
Ingredient ID: NPC165790
Ingredient ID: NPC160381
Ingredient ID: NPC154176
Ingredient ID: NPC143494
Ingredient ID: NPC142046
Ingredient ID: NPC136263
Ingredient ID: NPC133082
Ingredient ID: NPC118228
Ingredient ID: NPC107916
Ingredient ID: NPC105501
Ingredient ID: NPC100576
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Methyl-lysine/arginine binding protein | SMN1 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,CA9
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA9
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA12
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA12,CA9
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
CA9
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CA9
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
CA12,SMN1,CA9
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
CA12,SMN1
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CA12,CA9
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
CA12
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
