Collective Molecular Activities of the Plant: Cephalotaxus Fortunei
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Cancer
China; Myanmar
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
163 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
129 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
55 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC96670
Ingredient ID: NPC94048
Ingredient ID: NPC93729
Ingredient ID: NPC9224
Ingredient ID: NPC89432
Ingredient ID: NPC86189
Ingredient ID: NPC78147
Ingredient ID: NPC76884
Ingredient ID: NPC73503
Ingredient ID: NPC72349
Ingredient ID: NPC70036
Ingredient ID: NPC68926
Ingredient ID: NPC68811
Ingredient ID: NPC66823
Ingredient ID: NPC62044
Ingredient ID: NPC61652
Ingredient ID: NPC57272
Ingredient ID: NPC56457
Ingredient ID: NPC52912
Ingredient ID: NPC51371
Ingredient ID: NPC50898
Ingredient ID: NPC48313
Ingredient ID: NPC481110
Ingredient ID: NPC481109
Ingredient ID: NPC481108
Ingredient ID: NPC481107
Ingredient ID: NPC481106
Ingredient ID: NPC481105
Ingredient ID: NPC481104
Ingredient ID: NPC481103
Ingredient ID: NPC481102
Ingredient ID: NPC481101
Ingredient ID: NPC481100
Ingredient ID: NPC481099
Ingredient ID: NPC481098
Ingredient ID: NPC481097
Ingredient ID: NPC481096
Ingredient ID: NPC481095
Ingredient ID: NPC481094
Ingredient ID: NPC481093
Ingredient ID: NPC481092
Ingredient ID: NPC481091
Ingredient ID: NPC481090
Ingredient ID: NPC481089
Ingredient ID: NPC481088
Ingredient ID: NPC481087
Ingredient ID: NPC481086
Ingredient ID: NPC481085
Ingredient ID: NPC481084
Ingredient ID: NPC481083
Ingredient ID: NPC47452
Ingredient ID: NPC468994
Ingredient ID: NPC39325
Ingredient ID: NPC38749
Ingredient ID: NPC36607
Ingredient ID: NPC327174
Ingredient ID: NPC325967
Ingredient ID: NPC325924
Ingredient ID: NPC325693
Ingredient ID: NPC325652
Ingredient ID: NPC324846
Ingredient ID: NPC322950
Ingredient ID: NPC322674
Ingredient ID: NPC319549
Ingredient ID: NPC319527
Ingredient ID: NPC310674
Ingredient ID: NPC304341
Ingredient ID: NPC302556
Ingredient ID: NPC301189
Ingredient ID: NPC300095
Ingredient ID: NPC298186
Ingredient ID: NPC296518
Ingredient ID: NPC291450
Ingredient ID: NPC290791
Ingredient ID: NPC289751
Ingredient ID: NPC283274
Ingredient ID: NPC282017
Ingredient ID: NPC280026
Ingredient ID: NPC278228
Ingredient ID: NPC275552
Ingredient ID: NPC271540
Ingredient ID: NPC270560
Ingredient ID: NPC268808
Ingredient ID: NPC268298
Ingredient ID: NPC268221
Ingredient ID: NPC268151
Ingredient ID: NPC267732
Ingredient ID: NPC265624
Ingredient ID: NPC265310
Ingredient ID: NPC262908
Ingredient ID: NPC261012
Ingredient ID: NPC257239
Ingredient ID: NPC252791
Ingredient ID: NPC250028
Ingredient ID: NPC244994
Ingredient ID: NPC244501
Ingredient ID: NPC242396
Ingredient ID: NPC239326
Ingredient ID: NPC237156
Ingredient ID: NPC236636
Ingredient ID: NPC236431
Ingredient ID: NPC232451
Ingredient ID: NPC230087
Ingredient ID: NPC229087
Ingredient ID: NPC229086
Ingredient ID: NPC226967
Ingredient ID: NPC226453
Ingredient ID: NPC225118
Ingredient ID: NPC223848
Ingredient ID: NPC222439
Ingredient ID: NPC22062
Ingredient ID: NPC218465
Ingredient ID: NPC217810
Ingredient ID: NPC213329
Ingredient ID: NPC210545
Ingredient ID: NPC209971
Ingredient ID: NPC209761
Ingredient ID: NPC209172
Ingredient ID: NPC201451
Ingredient ID: NPC201182
Ingredient ID: NPC20045
Ingredient ID: NPC198118
Ingredient ID: NPC196836
Ingredient ID: NPC195736
Ingredient ID: NPC194432
Ingredient ID: NPC19176
Ingredient ID: NPC188646
Ingredient ID: NPC183991
Ingredient ID: NPC183953
Ingredient ID: NPC183950
Ingredient ID: NPC183544
Ingredient ID: NPC179694
Ingredient ID: NPC175662
Ingredient ID: NPC172572
Ingredient ID: NPC170787
Ingredient ID: NPC169922
Ingredient ID: NPC167072
Ingredient ID: NPC16647
Ingredient ID: NPC165797
Ingredient ID: NPC162970
Ingredient ID: NPC160075
Ingredient ID: NPC155185
Ingredient ID: NPC153441
Ingredient ID: NPC152114
Ingredient ID: NPC151345
Ingredient ID: NPC151007
Ingredient ID: NPC142364
Ingredient ID: NPC139053
Ingredient ID: NPC138299
Ingredient ID: NPC136446
Ingredient ID: NPC135262
Ingredient ID: NPC133704
Ingredient ID: NPC128061
Ingredient ID: NPC126571
Ingredient ID: NPC120301
Ingredient ID: NPC119485
Ingredient ID: NPC118968
Ingredient ID: NPC118930
Ingredient ID: NPC116698
Ingredient ID: NPC112845
Ingredient ID: NPC105258
Ingredient ID: NPC103343
Ingredient ID: NPC103239
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Isomerase | TOP2A | DNA topoisomerase II alpha | P11388 | CHEMBL1806 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Therapeutic Target | Oxidoreductase | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | P14061 | CHEMBL3181 |
| Therapeutic Target | Peptide receptor (family A GPCR) | OPRD1 | Delta opioid receptor | P41143 | CHEMBL236 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 938 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00001300 | A Randomized Study of the Effect of Adjuvant Chemotherapy With Doxorubicin and Ifosfamide With Mesna in the Treatment of High-Grade Adult Extremity Soft Tissue Sarcoma | sarcoma | Doxorubicin (NPC261012) | NP level |
| NCT00001339 | A Study of Combination Chemotherapy and Surgical Resection in the Treatment of Adrenocortical Carcinoma: Continuous Infusion Doxorubicin, Vincristine and Etoposide With Daily Mitotane Before and After Surgical Resection | carcinoma | Doxorubicin (NPC261012) | NP level |
| NCT00001384 | A Pilot Trial of AC (Adriamycin, Cyclophosphamide) Chemotherapy With G-CSF (Granulocyte Colony-Stimulating Factor) Followed by Infusional Taxol (Paclitaxel) as Adjuvant Treatment for High Risk Stage II and Stage III Breast Cancer Patients | breast cancer | Doxorubicin (NPC261012) | NP level |
| NCT00001498 | A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With Peripheral Blood Progenitor Cell Support, and Intensification With Paclitaxel and Doxorubicin for Patients With High-Risk Breast Cancer | breast cancer | Doxorubicin (NPC261012) | NP level |
| NCT00002105 | Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Bleomycin and Vincristine in the Treatment of AIDS-Related Kaposi's Sarcoma | Kaposi's sarcoma | Doxorubicin (NPC261012) | NP level |
| NCT00002318 | A Comparison of DOX-SL Versus Adriamycin Plus Bleomycin Plus Vincristine in the Treatment of Severe AIDS-Related Kaposi's Sarcoma | Kaposi's sarcoma | Doxorubicin (NPC261012) | NP level |
| NCT00002557 | Combination Chemotherapy in Patients With Advanced or Recurrent Mycosis Fungoides | lymphoma | Doxorubicin (NPC261012) | NP level |
| NCT00002565 | Combination Chemotherapy in Treating Patients With Intermediate-Grade or Immunoblastic Non-Hodgkin's Lymphoma | lymphoma | Doxorubicin (NPC261012) | NP level |
| NCT00002707 | Chemotherapy in Treating Women With Breast Cancer That Can Be Surgically Removed | breast cancer | Doxorubicin (NPC261012) | NP level |
| NCT00003150 | Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Older Patients With Non-Hodgkin's Lymphoma | lymphoma | Doxorubicin (NPC261012) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKA,DPP4
|
Acute leukaemias of ambiguous lineageDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A61 |
NCT02419755
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TOP2A,NFKB1,AURKA
NCT03059615,NCT03860844 |
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
OPRD1,AURKA,THPO,XDH,TOP2A,ACHE,TTR
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
AURKA,CYP1B1,DHCR7,XDH,DPP4,ACHE,GPBAR1,TTR
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
TTR
NCT02560051 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
AURKA,CYP19A1,TOP2A
NCT04047004 |
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT04852367
|
Adenoid cystic carcinomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH4302 |
NCT00581360
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
