Collective Molecular Activities of the Plant: Coleus Xanthanthus
Plant ID: NPO18923
Plant Latin Name: Coleus Xanthanthus
Taxonomy Genus: Coleus
Taxonomy Family: Lamiaceae
Plant External Links:
NCBI TaxonomyDB:
662900
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
74 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
69 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
16 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99632
Ingredient ID: NPC9713
Ingredient ID: NPC97100
Ingredient ID: NPC96156
Ingredient ID: NPC90287
Ingredient ID: NPC58680
Ingredient ID: NPC55654
Ingredient ID: NPC52262
Ingredient ID: NPC4654
Ingredient ID: NPC43129
Ingredient ID: NPC303423
Ingredient ID: NPC302814
Ingredient ID: NPC300780
Ingredient ID: NPC292606
Ingredient ID: NPC29055
Ingredient ID: NPC288110
Ingredient ID: NPC281373
Ingredient ID: NPC279204
Ingredient ID: NPC272411
Ingredient ID: NPC266170
Ingredient ID: NPC261095
Ingredient ID: NPC258985
Ingredient ID: NPC258271
Ingredient ID: NPC25267
Ingredient ID: NPC24882
Ingredient ID: NPC243721
Ingredient ID: NPC240934
Ingredient ID: NPC23947
Ingredient ID: NPC234516
Ingredient ID: NPC232075
Ingredient ID: NPC230659
Ingredient ID: NPC22851
Ingredient ID: NPC222046
Ingredient ID: NPC221687
Ingredient ID: NPC217463
Ingredient ID: NPC215623
Ingredient ID: NPC212171
Ingredient ID: NPC211126
Ingredient ID: NPC210487
Ingredient ID: NPC208425
Ingredient ID: NPC199851
Ingredient ID: NPC198738
Ingredient ID: NPC191116
Ingredient ID: NPC186209
Ingredient ID: NPC176601
Ingredient ID: NPC176021
Ingredient ID: NPC175079
Ingredient ID: NPC173915
Ingredient ID: NPC171486
Ingredient ID: NPC170860
Ingredient ID: NPC168704
Ingredient ID: NPC166551
Ingredient ID: NPC166009
Ingredient ID: NPC159125
Ingredient ID: NPC157487
Ingredient ID: NPC151592
Ingredient ID: NPC149323
Ingredient ID: NPC147785
Ingredient ID: NPC145974
Ingredient ID: NPC144946
Ingredient ID: NPC142195
Ingredient ID: NPC141930
Ingredient ID: NPC140447
Ingredient ID: NPC139660
Ingredient ID: NPC139419
Ingredient ID: NPC133036
Ingredient ID: NPC129721
Ingredient ID: NPC117451
Ingredient ID: NPC11565
Ingredient ID: NPC113600
Ingredient ID: NPC109826
Ingredient ID: NPC109147
Ingredient ID: NPC103624
Ingredient ID: NPC102370
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
