Collective Molecular Activities of the Plant: Anaxagorea Clavata
Plant ID: NPO18352
Plant Latin Name: Anaxagorea Clavata
Taxonomy Genus: Anaxagorea
Taxonomy Family: Annonaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
157 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
115 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
67 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99088
Ingredient ID: NPC95704
Ingredient ID: NPC95031
Ingredient ID: NPC92085
Ingredient ID: NPC91931
Ingredient ID: NPC90040
Ingredient ID: NPC88566
Ingredient ID: NPC86545
Ingredient ID: NPC85813
Ingredient ID: NPC85233
Ingredient ID: NPC79416
Ingredient ID: NPC79056
Ingredient ID: NPC76145
Ingredient ID: NPC72141
Ingredient ID: NPC69394
Ingredient ID: NPC68889
Ingredient ID: NPC66655
Ingredient ID: NPC65959
Ingredient ID: NPC63872
Ingredient ID: NPC53403
Ingredient ID: NPC50715
Ingredient ID: NPC50701
Ingredient ID: NPC49151
Ingredient ID: NPC47781
Ingredient ID: NPC47255
Ingredient ID: NPC46801
Ingredient ID: NPC45782
Ingredient ID: NPC4455
Ingredient ID: NPC40818
Ingredient ID: NPC38497
Ingredient ID: NPC3649
Ingredient ID: NPC32021
Ingredient ID: NPC31290
Ingredient ID: NPC312132
Ingredient ID: NPC311810
Ingredient ID: NPC311529
Ingredient ID: NPC307168
Ingredient ID: NPC306993
Ingredient ID: NPC306296
Ingredient ID: NPC305016
Ingredient ID: NPC29710
Ingredient ID: NPC297054
Ingredient ID: NPC296473
Ingredient ID: NPC29536
Ingredient ID: NPC294548
Ingredient ID: NPC288756
Ingredient ID: NPC282363
Ingredient ID: NPC279865
Ingredient ID: NPC278023
Ingredient ID: NPC277385
Ingredient ID: NPC27657
Ingredient ID: NPC273756
Ingredient ID: NPC27184
Ingredient ID: NPC270549
Ingredient ID: NPC266371
Ingredient ID: NPC263265
Ingredient ID: NPC262505
Ingredient ID: NPC261991
Ingredient ID: NPC261831
Ingredient ID: NPC259512
Ingredient ID: NPC257188
Ingredient ID: NPC255350
Ingredient ID: NPC252074
Ingredient ID: NPC251666
Ingredient ID: NPC249164
Ingredient ID: NPC248404
Ingredient ID: NPC247844
Ingredient ID: NPC2476
Ingredient ID: NPC245807
Ingredient ID: NPC243925
Ingredient ID: NPC242881
Ingredient ID: NPC241784
Ingredient ID: NPC240504
Ingredient ID: NPC239039
Ingredient ID: NPC236705
Ingredient ID: NPC233209
Ingredient ID: NPC232375
Ingredient ID: NPC227325
Ingredient ID: NPC226973
Ingredient ID: NPC224517
Ingredient ID: NPC223110
Ingredient ID: NPC222781
Ingredient ID: NPC221743
Ingredient ID: NPC22098
Ingredient ID: NPC220615
Ingredient ID: NPC219738
Ingredient ID: NPC216919
Ingredient ID: NPC216630
Ingredient ID: NPC215932
Ingredient ID: NPC214285
Ingredient ID: NPC213749
Ingredient ID: NPC212819
Ingredient ID: NPC209970
Ingredient ID: NPC205959
Ingredient ID: NPC205522
Ingredient ID: NPC202977
Ingredient ID: NPC201547
Ingredient ID: NPC201057
Ingredient ID: NPC196832
Ingredient ID: NPC196439
Ingredient ID: NPC191184
Ingredient ID: NPC190771
Ingredient ID: NPC188261
Ingredient ID: NPC18351
Ingredient ID: NPC182840
Ingredient ID: NPC18205
Ingredient ID: NPC179831
Ingredient ID: NPC179540
Ingredient ID: NPC17810
Ingredient ID: NPC177148
Ingredient ID: NPC176819
Ingredient ID: NPC176775
Ingredient ID: NPC174360
Ingredient ID: NPC173695
Ingredient ID: NPC173295
Ingredient ID: NPC169407
Ingredient ID: NPC168855
Ingredient ID: NPC168602
Ingredient ID: NPC167815
Ingredient ID: NPC167010
Ingredient ID: NPC165651
Ingredient ID: NPC164964
Ingredient ID: NPC164487
Ingredient ID: NPC163556
Ingredient ID: NPC162050
Ingredient ID: NPC160961
Ingredient ID: NPC158824
Ingredient ID: NPC154480
Ingredient ID: NPC154176
Ingredient ID: NPC149184
Ingredient ID: NPC147723
Ingredient ID: NPC146165
Ingredient ID: NPC145379
Ingredient ID: NPC142860
Ingredient ID: NPC142366
Ingredient ID: NPC13933
Ingredient ID: NPC138932
Ingredient ID: NPC138867
Ingredient ID: NPC138397
Ingredient ID: NPC138360
Ingredient ID: NPC132428
Ingredient ID: NPC129680
Ingredient ID: NPC128726
Ingredient ID: NPC12664
Ingredient ID: NPC12509
Ingredient ID: NPC120253
Ingredient ID: NPC120163
Ingredient ID: NPC116994
Ingredient ID: NPC116502
Ingredient ID: NPC116315
Ingredient ID: NPC116260
Ingredient ID: NPC110639
Ingredient ID: NPC108663
Ingredient ID: NPC104323
Ingredient ID: NPC103711
Ingredient ID: NPC10286
Ingredient ID: NPC101294
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Drug Transporter | ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | THRB | Thyroid hormone receptor beta-1 | P10828 | CHEMBL1947 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 25 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction;Myocardial Ischemia | Beta Carotene (NPC17810) | NP level |
| NCT00001986 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00016679 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT00080366 | Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00102596 | Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT00275418 | Beta Carotene From Natural Source for Patients With Non-Active Crohn's Disease | Crohn's disease | Beta Carotene (NPC17810) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PPARA,FFAR1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,AKR1C3,TSHR,NR1I2,CA9,SLCO1B1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,AKR1C3,ABCB1,FFAR4,NR1I2,CA9,FABP3,ALOX15,OR51E2,HIF1A
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
FABP5,ALOX15,OR51E2,SLCO1B1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
ALOX15,SLCO1B1
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
HIF1A
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
NCT00029679
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA12,ABCB1
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
HIF1A
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA9,CA12
NCT00908791 |
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
