Plant ID: NPO17434
Plant Latin Name: Sambucus Williamsii
Taxonomy Genus: Sambucus
Taxonomy Family: Adoxaceae
NCBI TaxonomyDB:
180062
Plant-of-the-World-Online:
n.a.
Unknown.
Ingredient ID: NPC95615
Ingredient ID: NPC78918
Ingredient ID: NPC48736
Ingredient ID: NPC485398
Ingredient ID: NPC485397
Ingredient ID: NPC485396
Ingredient ID: NPC485395
Ingredient ID: NPC485394
Ingredient ID: NPC40432
Ingredient ID: NPC38059
Ingredient ID: NPC34103
Ingredient ID: NPC3295
Ingredient ID: NPC319929
Ingredient ID: NPC311256
Ingredient ID: NPC307050
Ingredient ID: NPC29799
Ingredient ID: NPC286620
Ingredient ID: NPC273709
Ingredient ID: NPC263367
Ingredient ID: NPC257582
Ingredient ID: NPC23962
Ingredient ID: NPC23646
Ingredient ID: NPC230124
Ingredient ID: NPC228346
Ingredient ID: NPC219913
Ingredient ID: NPC214001
Ingredient ID: NPC202826
Ingredient ID: NPC187998
Ingredient ID: NPC185498
Ingredient ID: NPC178970
Ingredient ID: NPC165159
Ingredient ID: NPC164778
Ingredient ID: NPC161557
Ingredient ID: NPC158079
Ingredient ID: NPC156502
Ingredient ID: NPC153572
Ingredient ID: NPC148842
Ingredient ID: NPC143709
Ingredient ID: NPC141765
Ingredient ID: NPC139617
Ingredient ID: NPC131046
Ingredient ID: NPC126409
Ingredient ID: NPC115207
Ingredient ID: NPC114171
Ingredient ID: NPC113961
Ingredient ID: NPC111888
Ingredient ID: NPC10737
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Enzyme | NOS1 | Nitric-oxide synthase, brain | P29475 | CHEMBL3568 |
Therapeutic Target | Enzyme | NOS3 | Nitric-oxide synthase, endothelial | P29474 | CHEMBL4803 |
Therapeutic Target | Histone acetyltransferase | NCOA3 | Nuclear receptor coactivator 3 | Q9Y6Q9 | CHEMBL1615382 |
Therapeutic Target | Isomerase | TOP2B | DNA topoisomerase II beta | Q02880 | CHEMBL3396 |
Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
Therapeutic Target | Transient receptor potential channel | TRPV1 | Vanilloid receptor | Q8NER1 | CHEMBL4794 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
![]() | 978 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00000660 | Phase I Study of Weekly Oral VP-16 for AIDS-Associated Kaposi's Sarcoma | Kaposi's sarcoma | Etoposide (NPC185498) | ![]() |
NCT00001339 | A Study of Combination Chemotherapy and Surgical Resection in the Treatment of Adrenocortical Carcinoma: Continuous Infusion Doxorubicin, Vincristine and Etoposide With Daily Mitotane Before and After Surgical Resection | carcinoma | Etoposide (NPC185498) | ![]() |
NCT00001563 | EPOCH Chemotherapy +/- IL-12 for Previously Untreated and EPOCH Plus Rituximab for Previously Treated Patients With AIDS-Associated Lymphoma | Lymphoma, AIDS-Related | Etoposide (NPC185498) | ![]() |
NCT00002461 | Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Refractory Hodgkin's Disease or Non-Hodgkin's Lymphoma | lymphoma | Etoposide (NPC185498) | ![]() |
NCT00002471 | Combination Chemotherapy in Treating Patients With Acute B-Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma | leukemia;lymphoma | Etoposide (NPC185498) | ![]() |
NCT00002481 | Combination Chemotherapy and Radiation Therapy Plus Bone Marrow Transplantation in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma | lymphoma | Etoposide (NPC185498) | ![]() |
NCT00002488 | Combination Chemotherapy in Treating Patients With Intermediate-Grade or High-Grade Non-Hodgkin's Lymphoma Who Have Not Responded to Anthracycline-Containing Combination Chemotherapy | lymphoma | Etoposide (NPC185498) | ![]() |
NCT00002494 | Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia | leukemia;lymphoma | Etoposide (NPC185498) | ![]() |
NCT00002509 | High-Dose Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Poor-Prognosis Breast Cancer | breast cancer | Etoposide (NPC185498) | ![]() |
NCT00002510 | Chemotherapy and Radiation Therapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Non-Hodgkin's Lymphoma | lymphoma | Etoposide (NPC185498) | ![]() |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute basophilic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60.37 |
NCT00006363,NCT00369317
|
Acute erythroid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60.35 |
NCT00006363,NCT00003190,NCT00002798,NCT00369317
|
Acute megakaryoblastic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60.36 |
NCT00369317,NCT00002798,NCT00006363,NCT00003190
|
Acute monocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH9NE2 |
NCT00006363,NCT00369317,NCT00002798,NCT00003190
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TOP2B
NCT00002798,NCT00151242,NCT00369317,NCT02421939,NCT02773732,NCT00186966,NCT00780104,NCT00512252,NCT01729845,NCT00003190,NCT03926624,NCT01027923,NCT01411267,NCT02638428,NCT03860844,NCT01025778,NCT03568994,NCT02626338,NCT00660036,NCT00880243,NCT03118466,NCT03182244,NCT00003190,NCT00906945,NCT03591510,NCT02070458,NCT00079482,NCT00151255,NCT00315705,NCT03504410,NCT00006363,NCT03164057,NCT00939653,NCT04326439,NCT01237808,NCT01681537,NCT03839446,NCT00703820,NCT00774046,NCT03793478,NCT02631252,NCT02349178,NCT02039726,NCT02306291,NCT02400281,NCT01677949,NCT04293562,NCT00136084,NCT01180322,NCT00146120,NCT02632708,NCT01830777,NCT02848183 |
Acute myelomonocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH78Y4 |
NCT00369317,NCT00002798,NCT00003190,NCT00006363
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CASP3,NOS2
|
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT01958372,NCT00020709,NCT00042835
|