Collective Molecular Activities of the Plant: Saposhnikovia Divaricata
Country/Region:
ChinaTraditional Medicine System:
TCM; KampoChina; Mongolia; South Africa
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
95 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
71 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
48 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98179
Ingredient ID: NPC88445
Ingredient ID: NPC86353
Ingredient ID: NPC85773
Ingredient ID: NPC85104
Ingredient ID: NPC84894
Ingredient ID: NPC84807
Ingredient ID: NPC78551
Ingredient ID: NPC77822
Ingredient ID: NPC76336
Ingredient ID: NPC7526
Ingredient ID: NPC75204
Ingredient ID: NPC74539
Ingredient ID: NPC73854
Ingredient ID: NPC66700
Ingredient ID: NPC65611
Ingredient ID: NPC56913
Ingredient ID: NPC55063
Ingredient ID: NPC52607
Ingredient ID: NPC52403
Ingredient ID: NPC52086
Ingredient ID: NPC51146
Ingredient ID: NPC49059
Ingredient ID: NPC48367
Ingredient ID: NPC47163
Ingredient ID: NPC46248
Ingredient ID: NPC37030
Ingredient ID: NPC33320
Ingredient ID: NPC312043
Ingredient ID: NPC306149
Ingredient ID: NPC305078
Ingredient ID: NPC304443
Ingredient ID: NPC300250
Ingredient ID: NPC297643
Ingredient ID: NPC296442
Ingredient ID: NPC296377
Ingredient ID: NPC290613
Ingredient ID: NPC29
Ingredient ID: NPC287182
Ingredient ID: NPC28701
Ingredient ID: NPC279916
Ingredient ID: NPC278711
Ingredient ID: NPC275856
Ingredient ID: NPC275462
Ingredient ID: NPC273982
Ingredient ID: NPC273730
Ingredient ID: NPC270665
Ingredient ID: NPC266144
Ingredient ID: NPC256141
Ingredient ID: NPC253574
Ingredient ID: NPC249297
Ingredient ID: NPC249045
Ingredient ID: NPC243728
Ingredient ID: NPC243509
Ingredient ID: NPC239406
Ingredient ID: NPC234536
Ingredient ID: NPC231229
Ingredient ID: NPC230301
Ingredient ID: NPC230221
Ingredient ID: NPC224194
Ingredient ID: NPC220111
Ingredient ID: NPC220089
Ingredient ID: NPC210460
Ingredient ID: NPC207581
Ingredient ID: NPC207002
Ingredient ID: NPC206452
Ingredient ID: NPC202494
Ingredient ID: NPC201713
Ingredient ID: NPC200454
Ingredient ID: NPC198985
Ingredient ID: NPC19834
Ingredient ID: NPC180051
Ingredient ID: NPC17521
Ingredient ID: NPC171990
Ingredient ID: NPC166942
Ingredient ID: NPC164646
Ingredient ID: NPC163533
Ingredient ID: NPC156461
Ingredient ID: NPC148835
Ingredient ID: NPC142753
Ingredient ID: NPC138865
Ingredient ID: NPC131624
Ingredient ID: NPC129701
Ingredient ID: NPC128457
Ingredient ID: NPC127447
Ingredient ID: NPC122962
Ingredient ID: NPC118246
Ingredient ID: NPC117543
Ingredient ID: NPC115694
Ingredient ID: NPC114992
Ingredient ID: NPC11232
Ingredient ID: NPC112196
Ingredient ID: NPC111897
Ingredient ID: NPC108218
Ingredient ID: NPC100773
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2A13 | Cytochrome P450 2A13 | Q16696 | CHEMBL3542436 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Other cytosolic protein | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Therapeutic Target | Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA2A | Adenosine A2a receptor | P29274 | CHEMBL251 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA3 | Adenosine A3 receptor | P0DMS8 | CHEMBL256 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA1 | Adenosine A1 receptor | P30542 | CHEMBL226 |
| Therapeutic Target | Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 45 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01690884 | Effect of Ticagrelor vs. Dipyridamole on Adenosine Uptake | coronary artery disease | Adenosine (NPC156461) | NP level |
| NCT00781404 | Myocardial Protection With Adenosine During Primary Percutaneous Coronary Intervention in Pts With STEMI | acute myocardial infarction | Adenosine (NPC156461) | NP level |
| NCT00349921 | Clonidine Versus Adenosine to Treat Neuropathic Pain | pain | Adenosine (NPC156461) | NP level |
| NCT00004359 | Phase II Pilot Study of Extracorporeal Phototherapy for Epidermolysis Bullosa Acquisita | epidermolysis bullosa acquisita | Methoxsalen (NPC33320) | NP level |
| NCT00056056 | Ultraviolet Light Therapy Using Methoxsalen With or Without Bexarotene in Treating Patients With Mycosis Fungoides | lymphoma | Methoxsalen (NPC33320) | NP level |
| NCT01686594 | PUVA Maintenance Therapy in Mycosis Fungoides | mycosis fungoides | Methoxsalen (NPC33320) | NP level |
| NCT00533195 | Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis | atopic eczema | Bergapten (NPC74539) | NP level |
| NCT02681913 | Adenosine as an Adjunct to Blood Cardioplegia | cardiomyopathy | Adenosine (NPC156461) | NP level |
| NCT00590070 | THE REOPEN-AMI STUDY - Intracoronary Nitroprusside Versus Adenosine in Acute Myocardial Infarction | myocardial infarction | Adenosine (NPC156461) | NP level |
| NCT00639717 | Addition of Etanercept and Extracorporeal Photopheresis (ECP) to Standard Graft-Versus-Host Disease (GVHD) Prophylaxis in Stem Cell Transplant | graft versus host disease | Methoxsalen (NPC33320) | NP level |
| NCT02867878 | Adenosin to Rapidly Reverse Left Ventricle Impairment in Takotsubo Syndrome | Takotsubo cardiomyopathy | Adenosine (NPC156461) | NP level |
| NCT00282503 | Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Acute Graft Versus-Host Disease | acute graft vs. host disease | Methoxsalen (NPC33320) | NP level |
| NCT04666454 | BROKEN-SWEDEHEART-Optimized Pharmacological Treatment for Broken Heart (Takotsubo) Syndrome | Takotsubo cardiomyopathy | Adenosine (NPC156461) | NP level |
| NCT00221000 | Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid Arthritis | rheumatoid arthritis | Methoxsalen (NPC33320) | NP level |
| NCT01747174 | REperfusion Facilitated by LOcal Adjunctive Therapy in ST-elevation Myocardial Infarction | ST Elevation Myocardial Infarction | Adenosine (NPC156461) | NP level |
| NCT00179010 | AMP as a Better Delivery System of Adenosine | ischemia | Adenosine (NPC156461) | NP level |
| NCT03563040 | Study of Photopheresis in the Treatment of Erythrodermic MF and SS | Sezary's disease;mycosis fungoides | Methoxsalen (NPC33320) | NP level |
| NCT03236311 | A Dose Titration Study to Assess the Effects of SAR407899 in Patients With MVA and/or Persistent Stable Angina Despite Angiographically Successful PCI | coronary artery disease | Adenosine (NPC156461) | NP level |
| NCT00930566 | Extracorporal Photopheresis Pilot Study | lymphoid neoplasm | Methoxsalen (NPC33320) | NP level |
| NCT00580905 | Role of Adenosine in the Release of VEGF and Cytokines | inflammation | Adenosine (NPC156461) | NP level |
| NCT05014061 | Adenosine's Effect on STunning Resolution in Acute Myocardial Infarction | Myocardial Ischemia | Adenosine (NPC156461) | NP level |
| NCT01123525 | Adenosine Cardioplegia | angina pectoris | Adenosine (NPC156461) | NP level |
| NCT03512756 | A Randomized Phase 2/3 Multi-Center Study of SM-88 in Patients With Metastatic Pancreatic Cancer | pancreatic carcinoma | Methoxsalen (NPC33320) | NP level |
| NCT04588441 | The ARCTIC Trial: Aerosolized Inhaled Adenosine Treatment in Patients With Acute Respiratory Distress Syndrome (ARDS) Caused by COVID-19 | acute respiratory distress syndrome | Adenosine (NPC156461) | NP level |
| NCT00565188 | Application of ATP Infusions in Palliative Home Care | cancer | Adenosine (NPC156461) | NP level |
| NCT00054613 | Safety and Efficacy Study of Photopheresis Plus Standard Therapy to Treat Chronic Graft-versus-Host Disease | graft versus host disease | Methoxsalen (NPC33320) | NP level |
| NCT00054600 | Safety and Efficacy Study of Photopheresis With UVADEX to Prevent Graft-versus-Host Disease | graft versus host disease | Methoxsalen (NPC33320) | NP level |
| NCT00005092 | Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer | leukemia;multiple myeloma;myelodysplastic syndrome | Psoralen (NPC51146) | NP level |
| NCT04291261 | Extracorporal Photopheresis With UVADEX Plus Standard Steroid Treatment for High Risk Acute Graft-versus-host Disease | acute graft vs. host disease | Methoxsalen (NPC33320) | NP level |
| NCT00284323 | Salvage: Postconditioning With Adenosine for STEMI | ST Elevation Myocardial Infarction | Adenosine (NPC156461) | NP level |
| NCT04986605 | Extracorporeal Photopheresis in Early Diffuse Cutaneous Systemic Sclerosis | diffuse scleroderma | Methoxsalen (NPC33320) | NP level |
| NCT00845689 | Prevention of Liver Damage During Liver Surgery | neoplasm | Adenosine (NPC156461) | NP level |
| NCT02524847 | Methoxsalen and Extracorporeal Photopheresis (ECP) for the Treatment of Pediatric Participants With Steroid Refractory Acute Graft Versus Host Disease | acute graft vs. host disease | Methoxsalen (NPC33320) | NP level |
| NCT00751491 | Clopidogrel Versus Adenosin in Non Urgent Percutaneous Coronary Intervention (PCI) | angina pectoris | Adenosine (NPC156461) | NP level |
| NCT00714103 | 8-Chloro-Adenosine in Chronic Lymphocytic Leukemia | chronic lymphocytic leukemia | Adenosine (NPC156461) | NP level |
| NCT04392362 | A Trial to Compare American Heart Association (AHA) and Simple (SIM)Method to Give Adenosine to Treat Supra-ventricular Tachycardia (SVT) | ventricular tachycardia | Adenosine (NPC156461) | NP level |
| NCT03032965 | Adenosine to Assess Complete Conduction Block During Catheter Ablation of Paroxysmal Atrial Fibrillation | atrial fibrillation | Adenosine (NPC156461) | NP level |
| NCT01593644 | Phase II Study for the Diagnosis and Functional Assessment of CAD Using Transthoracic-Echodoppler | coronary artery disease | Adenosine (NPC156461) | NP level |
| NCT00298636 | Dose-Response of Adenosine for Perioperative Pain | pain | Adenosine (NPC156461) | NP level |
| NCT01932112 | Adenosine Effect on Persistent Pulmonary Vein Isolation Line Evaluation (APPLE Trial) | atrial fibrillation | Adenosine (NPC156461) | NP level |
| NCT00612521 | Prophylactic Intra-coronary Adenosine to Prevent Post Coronary Artery Stenting Myonecrosis | coronary stenosis | Adenosine (NPC156461) | NP level |
| NCT00030589 | Chemotherapy and Photodynamic Therapy in Treating Patients With Cutaneous T-Cell Lymphoma | lymphoma | Methoxsalen (NPC33320) | NP level |
| NCT00221026 | Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Crohn's Disease | Crohn's disease | Methoxsalen (NPC33320) | NP level |
| NCT00056355 | Extracorporeal Photopheresis to Maintain Symptoms Remission During Steroid Withdrawal in Patients With Steroid-Dependent Crohn's Disease | Crohn's disease | Methoxsalen (NPC33320) | NP level |
| NCT03778996 | SM-88 Maintenance Therapy for Advanced Ewing's Sarcoma and as Salvage Therapy for Sarcoma | Ewing sarcoma | Methoxsalen (NPC33320) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
ADORA3,ACHE,CA9,TRPA1,ADORA3,CA9,TRPA1,F2,TSHR
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ADORA3,ACHE,CYP1B1,CA9,ADORA2A,TRPA1,F2,CYP2C19
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
ADORA3,ACHE,CYP1B1,CA9,ADORA2A,TRPA1,MAPT
|
Graft-versus-host diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4B24 |
NCT00282503,NCT02524847,NCT00054600,NCT04291261,NCT00639717,NCT00054613
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
ADORA3,ADORA1,CYP1A2,CA9,TSHR,CYP2A13
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
ADORA1,CA9,MAPT,MAPT,CA9,ADORA1
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
ADORA1,CA9,TRPA1,TSHR,CYP2A13
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
ACHE,ADORA1,CA9,TRPA1,TSHR
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ACHE,CYP2C19,ADORA2A,CYP1A1,KDM4E
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,CA9,TRPA1,F2,TSHR
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CYP2A6,CA9,ADORA2A,TRPA1,CYP2A13
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
CA9,CDK9
NCT00030589,NCT00056056 |
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
CA9,ADORA2A,ADORA3,CDK9
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
ACHE,MAPT,ADORA1,ADORA2A
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
ACHE,ADORA1,ADORA2A,MAPT
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
ADORA1,CA9,TRPA1,MAPT
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
ADORA3,ADORA2A,TRPA1,TSHR
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
CA9,TRPA1,F2,TSHR
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
ADORA3,CYP1B1,CA9,TSHR
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
ACHE,ADORA2A,TRPA1,F2
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
NCT00751491,NCT01123525 |
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
ADORA1,ADORA2A,ADORA3
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
ACHE
NCT00298636,NCT00349921 |
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
MAPT,ADORA1,ACHE
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
ADORA2A,ADORA1,ACHE
|
Mycosis fungoidesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B01 |
CYP2A6
NCT03563040,NCT01686594 |
coronary artery diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Y-BA8Z |
NCT01690884,NCT03236311,NCT01593644
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
CA9,TRPA1,F2
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
TRPA1,ADORA3,CA9
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
CA9,CYP1A1,F2
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CYP1A1,ADORA3,CA9
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CYP1A1,CA9,F2
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
CYP1B1,ADORA3,TRPA1
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
ADORA1,ADORA2A
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
F2
NCT00590070 |
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT,CDK9
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
ADORA3,CYP2A6
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAPT,ACHE
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
MAPT,ADORA2A
|
Orthostatic hypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA21 |
ADORA2A,ADORA1
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
ADORA3
NCT00221000 |
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
NCT03032965,NCT01932112
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
NCT00056355,NCT00221026
|
Stress-induced cardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43.5 |
NCT02867878,NCT04666454
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT00284323,NCT01747174
|
NADisease Category: NADisease ICD-11 Code: NA |
NCT00580905,NCT04986605
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
CYP1A1,TSHR
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
ADORA2A,ACHE
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
ACHE,ADORA2A
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
ADORA3,ADORA2A
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP1A2,CA9
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
CYP1A1,ACHE
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CYP1B1,ADORA1
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP1A2,CYP1A1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CA9,ADORA1
|
Nutritional deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B50-5B71 |
F2
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
F2
|
Diabetic foot ulcerDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD54 |
ADORA2A
|
Vasomotor/allergic rhinitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA08 |
ADORA2A
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
ADORA2A
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
F2
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
F2
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
ADORA2A
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
ADORA3
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ACHE
|
Unspecific substance harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
ACHE
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
ADORA2A
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
F2
|
Coagulation defectDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B10 |
F2
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
ADORA2A
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
ADORA2A
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
CA9
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
ACHE
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
F2
|
Upper respiratory tract disorderDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0Z |
TRPA1
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
ADORA2A
|
Parasitic worm infestationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F90 |
ACHE
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
TRPA1
|
Unspecific substance use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4Z |
ADORA2A
|
Oesophageal/gastroduodenal disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD90 |
ACHE
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
Radionuclide imagingDisease Category: NADisease ICD-11 Code: N.A. |
ADORA2A
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
ACHE
|
Coronary thrombosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA43 |
F2
|
Hypo-thyroidismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A00 |
TSHR
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
F2
|
Coronary atherosclerosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA80 |
ADORA2A
|
Thyroid cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10 |
TSHR
|
Mature B-cell leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82 |
CDK9
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
ADORA2A
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
CDK9
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA9
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
ADORA3
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
F2
|
Mature B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A85 |
CDK9
|
Cardiac arrhythmiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC9Z |
ADORA1
|
Hepatitis virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50-1E51 |
ADORA3
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|
Supraventricular tachyarrhythmiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81 |
ADORA1
|
PediculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G00 |
ACHE
|
Neoplasms of haematopoietic or lymphoid tissues, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B3Z |
NCT00930566
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
NCT00005092
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
NCT00005092
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NCT00533195
|
LeukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60-2B33 |
NCT00005092
|
Sezary syndromeDisease Category: X.Extension CodesDisease ICD-11 Code: XH8HN3 |
NCT03563040
|
IschemiaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B10-8B11 |
NCT00179010
|
Ventricular tachycardiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC71.0 |
NCT04392362
|
Ewing sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B52 |
NCT03778996
|
Chronic lymphocytic leukaemia or small lymphocytic lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82.0 |
NCT00714103
|
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT00845689
|
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT00565188
|
CardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43 |
NCT02681913
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404
|
Epidermolysis bullosa acquisitaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EB43 |
NCT00004359
|
Ischaemic heart diseases, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA6Z |
NCT05014061
|
Diseases of coronary artery, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Z |
NCT00612521
|
Malignant neoplasm of pancreas, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.Z |
NCT03512756
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04588441
|
Myelodysplastic syndromes, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A3Z |
TSHR
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
TRPA1
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
CYP2A13
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Intrauterine growth restrictionDisease Category: 19.Certain conditions originating in the perinatal periodDisease ICD-11 Code: KA20.1 |
ADORA2A
|
Myotonic dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71.0 |
CYP1A1
|
Pre-eclampsiaDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA24 |
ADORA2A
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
F2
|
Pneumonia due to PseudomonasaeruginosaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40.05 |
TRPA1
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
CA9
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
ACHE
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
ACHE
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
ADORA2A
|
Heart failure, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD1Z |
CYP1B1
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
ADORA3
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
ACHE
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
ADORA3
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
