CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Aconitum Pseudohuiliense

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PLANiTS DNA barcode

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Taxonomic Information

Plant ID: NPO15760
Plant Latin Name: Aconitum Pseudohuiliense
Taxonomy Genus: Aconitum
Taxonomy Family: Ranunculaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution

China

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

47 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

17 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

24 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC80302

Ingredient ID: NPC76662

Ingredient ID: NPC75384

Ingredient ID: NPC73219

Ingredient ID: NPC6913

Ingredient ID: NPC50880

Ingredient ID: NPC46335

Ingredient ID: NPC38343

Ingredient ID: NPC33338

Ingredient ID: NPC310342

Ingredient ID: NPC305307

Ingredient ID: NPC294558

Ingredient ID: NPC286956

Ingredient ID: NPC282812

Ingredient ID: NPC279406

Ingredient ID: NPC278906

Ingredient ID: NPC277510

Ingredient ID: NPC272552

Ingredient ID: NPC264084

Ingredient ID: NPC261324

Ingredient ID: NPC256849

Ingredient ID: NPC255246

Ingredient ID: NPC248498

Ingredient ID: NPC236202

Ingredient ID: NPC234222

Ingredient ID: NPC227491

Ingredient ID: NPC226315

Ingredient ID: NPC226108

Ingredient ID: NPC224161

Ingredient ID: NPC223548

Ingredient ID: NPC219876

Ingredient ID: NPC198554

Ingredient ID: NPC195952

Ingredient ID: NPC185392

Ingredient ID: NPC185231

Ingredient ID: NPC159451

Ingredient ID: NPC157417

Ingredient ID: NPC156654

Ingredient ID: NPC139940

Ingredient ID: NPC136014

Ingredient ID: NPC130182

Ingredient ID: NPC129800

Ingredient ID: NPC126029

Ingredient ID: NPC119133

Ingredient ID: NPC118284

Ingredient ID: NPC11016

Ingredient ID: NPC108811

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

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Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Enzyme	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Therapeutic Target	Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Therapeutic Target	Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Therapeutic Target	Protein Kinase	SRC	Tyrosine-protein kinase SRC	P12931	CHEMBL267
Therapeutic Target	Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Therapeutic Target	Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Therapeutic Target	Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Therapeutic Target	Protein Kinase	PTK2	Focal adhesion kinase 1	Q05397	CHEMBL2695
Therapeutic Target	Protein Kinase	ALK	ALK tyrosine kinase receptor	Q9UM73	CHEMBL4247
Therapeutic Target	Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040

Showing 1 to 10 of 12 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	87

Clinical trial details

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NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00223691	Treatment of Orthostatic Hypotension in Autonomic Failure	orthostatic hypotension	Caffeine (NPC256849)	NP level
NCT00302289	B181: Stimulation of Thermogenesis by Bio-Active Food Ingredients	obesity	Caffeine (NPC256849)	NP level
NCT00377975	"Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat	obesity	Caffeine (NPC256849)	NP level
NCT00388128	Caffeine and Intermittent Claudication	intermittent vascular claudication	Caffeine (NPC256849)	NP level
NCT00432887	Experimental Studies of the Effects of Caffeine on Glucose Regulation	type 2 diabetes mellitus	Caffeine (NPC256849)	NP level
NCT00437632	Study To Investigate If Repeat Doses Of GSK598809 Are Safe And Well Tolerated And To Evaluate Blood Levels Of GSK598809	substance dependence	Caffeine (NPC256849)	NP level
NCT00443170	A Placebo-controlled Study to Investigate the Safety, and Pharmacokinetics of Oral GSK626616AC in Healthy Subjects	anemia (phenotype)	Caffeine (NPC256849)	NP level
NCT00459420	Caffeine for Excessive Daytime Somnolence in Parkinson's Disease	Parkinson disease	Caffeine (NPC256849)	NP level
NCT00471952	Maxalt 10mg Plus Caffeine 75mg in the Acute Treatment of Migraine Headache	migraine with aura;migraine without aura	Caffeine (NPC256849)	NP level
NCT00495092	Efficacy of Caffeine, With and Without Biperiden, in the Detoxification of Cocaine Dependent Patients	cocaine dependence	Caffeine (NPC256849)	NP level

Showing 1 to 10 of 87 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

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Associated Disease of the Plant	Association Type & Detailed Evidence
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	KDR,AKR1B1
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	AXL,NFKB1,SRC
Acute upper respiratory infection Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA07	DRD3
Acute/subacute hepatic failure Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB91	NFKB1
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	SNCA,ALK,CA2,CA14,AXL
Adrenal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	ALK
Age-associated cognitive decline Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MB21.0	NCT05170464
Alcohol dependence Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C40.2	NCT01289561
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	KDR,DRD3,SNCA NCT00726726,NCT00692510,NCT04570085
Amyotrophic lateral sclerosis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B60.0	NCT02655614

Showing 1 to 10 of 176 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Aconitum Pseudohuiliense

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

47 All known Ingredients in Total

17 Ingredients with Acceptable Bioavailablity

24 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Acute diabete complication

Acute myeloid leukaemia

Acute upper respiratory infection

Acute/subacute hepatic failure

Adenocarcinoma of pancreas

Adrenal cancer

Age-associated cognitive decline

Alcohol dependence

Alzheimer disease

Amyotrophic lateral sclerosis

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities