CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Senecio Desfontainei

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO15588
Plant Latin Name: Senecio Desfontainei
Taxonomy Genus: Senecio
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

48 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

21 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

18 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC98872

Ingredient ID: NPC94101

Ingredient ID: NPC91580

Ingredient ID: NPC8203

Ingredient ID: NPC80854

Ingredient ID: NPC80837

Ingredient ID: NPC76376

Ingredient ID: NPC72652

Ingredient ID: NPC63020

Ingredient ID: NPC5280

Ingredient ID: NPC50114

Ingredient ID: NPC47301

Ingredient ID: NPC37502

Ingredient ID: NPC34700

Ingredient ID: NPC310957

Ingredient ID: NPC307063

Ingredient ID: NPC304423

Ingredient ID: NPC298395

Ingredient ID: NPC290598

Ingredient ID: NPC279461

Ingredient ID: NPC2789

Ingredient ID: NPC27786

Ingredient ID: NPC265077

Ingredient ID: NPC246654

Ingredient ID: NPC242580

Ingredient ID: NPC233395

Ingredient ID: NPC233122

Ingredient ID: NPC231063

Ingredient ID: NPC230920

Ingredient ID: NPC227925

Ingredient ID: NPC227139

Ingredient ID: NPC224883

Ingredient ID: NPC203981

Ingredient ID: NPC200684

Ingredient ID: NPC192864

Ingredient ID: NPC192744

Ingredient ID: NPC187021

Ingredient ID: NPC180391

Ingredient ID: NPC178383

Ingredient ID: NPC176025

Ingredient ID: NPC175972

Ingredient ID: NPC167240

Ingredient ID: NPC153344

Ingredient ID: NPC149203

Ingredient ID: NPC131709

Ingredient ID: NPC119555

Ingredient ID: NPC114822

Ingredient ID: NPC110699

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Enzyme	CES1	Acyl coenzyme A:cholesterol acyltransferase	P23141	CHEMBL2265
Therapeutic Target	Nuclear hormone receptor subfamily 1	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Therapeutic Target	Transferase	GSTP1	Glutathione S-transferase Pi	P09211	CHEMBL3902

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	CES1,GSTP1,LMNA
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	GSTP1,LMNA
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	GSTP1,LMNA
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	GSTP1,LMNA
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	GSTP1,LMNA
Hyper-lipoproteinaemia Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C80	CES1
Synthesis disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C52-5C59	CES1
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	GSTP1
Pancreatic cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10	GSTP1
Lung cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25	GSTP1
Chronic arterial occlusive disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD4Z	CES1
Colorectal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B91	GSTP1
Myelodysplastic syndrome Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A37	GSTP1
Peroxisomal disease Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C57	CES1
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	GSTP1
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	GSTP1
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	GSTP1
Melanoma of skin Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30	GSTP1
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	LMNA
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	LMNA

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Senecio Desfontainei

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

48 All known Ingredients in Total

21 Ingredients with Acceptable Bioavailablity

18 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Adenocarcinoma of pancreas

Malignant neoplasms of biliary tract, distal bile duct

Diffuse large B-cell lymphomas

Mesothelioma of pleura

Superficial ovarian endometriosis

Hyper-lipoproteinaemia

Synthesis disorder

Solid tumour/cancer

Pancreatic cancer

Lung cancer

Chronic arterial occlusive disease

Colorectal cancer

Myelodysplastic syndrome

Peroxisomal disease

Carcinosarcoma of uterus

Serous cystadenoma,borderline malignancy of ovary

Hepatoblastoma

Melanoma of skin

Chikungunya virus disease

Glioblastoma of brain

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities