Collective Molecular Activities of the Plant: Coriaria Myrtifolia
Plant ID: NPO15094
Plant Latin Name: Coriaria Myrtifolia
Taxonomy Genus: Coriaria
Taxonomy Family: Coriariaceae
Plant External Links:
NCBI TaxonomyDB:
3460
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
51 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
32 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
19 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC83409
Ingredient ID: NPC8066
Ingredient ID: NPC80402
Ingredient ID: NPC73144
Ingredient ID: NPC57262
Ingredient ID: NPC55701
Ingredient ID: NPC48999
Ingredient ID: NPC38141
Ingredient ID: NPC34771
Ingredient ID: NPC312989
Ingredient ID: NPC306927
Ingredient ID: NPC297344
Ingredient ID: NPC293940
Ingredient ID: NPC280878
Ingredient ID: NPC26427
Ingredient ID: NPC257847
Ingredient ID: NPC244023
Ingredient ID: NPC238129
Ingredient ID: NPC229390
Ingredient ID: NPC224088
Ingredient ID: NPC223534
Ingredient ID: NPC223008
Ingredient ID: NPC2230
Ingredient ID: NPC217785
Ingredient ID: NPC213682
Ingredient ID: NPC213234
Ingredient ID: NPC21190
Ingredient ID: NPC211772
Ingredient ID: NPC208676
Ingredient ID: NPC20558
Ingredient ID: NPC197413
Ingredient ID: NPC191662
Ingredient ID: NPC190729
Ingredient ID: NPC18407
Ingredient ID: NPC180020
Ingredient ID: NPC172751
Ingredient ID: NPC166153
Ingredient ID: NPC157655
Ingredient ID: NPC153719
Ingredient ID: NPC152728
Ingredient ID: NPC147807
Ingredient ID: NPC141210
Ingredient ID: NPC135654
Ingredient ID: NPC133302
Ingredient ID: NPC130489
Ingredient ID: NPC12794
Ingredient ID: NPC124834
Ingredient ID: NPC123467
Ingredient ID: NPC12226
Ingredient ID: NPC109650
Ingredient ID: NPC104287
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
