Collective Molecular Activities of the Plant: Piper Hostmannianum
Plant ID: NPO14386
Plant Latin Name: Piper Hostmannianum
Taxonomy Genus: Piper
Taxonomy Family: Piperaceae
Plant External Links:
NCBI TaxonomyDB:
511544
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
94 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
66 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
11 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC91411
Ingredient ID: NPC87590
Ingredient ID: NPC86906
Ingredient ID: NPC82989
Ingredient ID: NPC82329
Ingredient ID: NPC80436
Ingredient ID: NPC74856
Ingredient ID: NPC7214
Ingredient ID: NPC69144
Ingredient ID: NPC67816
Ingredient ID: NPC64246
Ingredient ID: NPC60657
Ingredient ID: NPC60372
Ingredient ID: NPC58208
Ingredient ID: NPC49653
Ingredient ID: NPC49070
Ingredient ID: NPC48660
Ingredient ID: NPC46915
Ingredient ID: NPC45267
Ingredient ID: NPC4230
Ingredient ID: NPC40174
Ingredient ID: NPC36266
Ingredient ID: NPC354
Ingredient ID: NPC34884
Ingredient ID: NPC32905
Ingredient ID: NPC306581
Ingredient ID: NPC306286
Ingredient ID: NPC305201
Ingredient ID: NPC300241
Ingredient ID: NPC297600
Ingredient ID: NPC293776
Ingredient ID: NPC284838
Ingredient ID: NPC283277
Ingredient ID: NPC280090
Ingredient ID: NPC279514
Ingredient ID: NPC271648
Ingredient ID: NPC262372
Ingredient ID: NPC26181
Ingredient ID: NPC26176
Ingredient ID: NPC258693
Ingredient ID: NPC248058
Ingredient ID: NPC24733
Ingredient ID: NPC244582
Ingredient ID: NPC243935
Ingredient ID: NPC239126
Ingredient ID: NPC229215
Ingredient ID: NPC22771
Ingredient ID: NPC226850
Ingredient ID: NPC220949
Ingredient ID: NPC219768
Ingredient ID: NPC217788
Ingredient ID: NPC21773
Ingredient ID: NPC217129
Ingredient ID: NPC216693
Ingredient ID: NPC213631
Ingredient ID: NPC208580
Ingredient ID: NPC200794
Ingredient ID: NPC197292
Ingredient ID: NPC196134
Ingredient ID: NPC195456
Ingredient ID: NPC18509
Ingredient ID: NPC182962
Ingredient ID: NPC178831
Ingredient ID: NPC169375
Ingredient ID: NPC168551
Ingredient ID: NPC164973
Ingredient ID: NPC163329
Ingredient ID: NPC158755
Ingredient ID: NPC158162
Ingredient ID: NPC158032
Ingredient ID: NPC154397
Ingredient ID: NPC152829
Ingredient ID: NPC152039
Ingredient ID: NPC149281
Ingredient ID: NPC148164
Ingredient ID: NPC145773
Ingredient ID: NPC14522
Ingredient ID: NPC140419
Ingredient ID: NPC134847
Ingredient ID: NPC127780
Ingredient ID: NPC12578
Ingredient ID: NPC121855
Ingredient ID: NPC120458
Ingredient ID: NPC118329
Ingredient ID: NPC116350
Ingredient ID: NPC116123
Ingredient ID: NPC115311
Ingredient ID: NPC113405
Ingredient ID: NPC109268
Ingredient ID: NPC105504
Ingredient ID: NPC1041
Ingredient ID: NPC103593
Ingredient ID: NPC102622
Ingredient ID: NPC101042
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Methyl-lysine/arginine binding protein | SMN1 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | NR3C1 | Glucocorticoid receptor | P04150 | CHEMBL2034 |
| Therapeutic Target | Secreted protein | SERPINA6 | Corticosteroid binding globulin | P08185 | CHEMBL2421 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HRH3 | Histamine H3 receptor | Q9Y5N1 | CHEMBL264 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2A | Alpha-2a adrenergic receptor | P08913 | CHEMBL1867 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2C | Alpha-2c adrenergic receptor | P18825 | CHEMBL1916 |
| Therapeutic Target | Transcription factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 154 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00001521 | Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia | congenital adrenal hyperplasia | Hydrocortisone (NPC18509) | NP level |
| NCT00002471 | Combination Chemotherapy in Treating Patients With Acute B-Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma | leukemia;lymphoma | Hydrocortisone (NPC18509) | NP level |
| NCT00002494 | Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia | leukemia;lymphoma | Hydrocortisone (NPC18509) | NP level |
| NCT00002552 | Chemotherapy Plus Bone Marrow Transplantation in Treating Patients With Refractory Non-Hodgkin's Lymphoma, Hodgkin's Disease, or Multiple Myeloma | multiple myeloma | Hydrocortisone (NPC18509) | NP level |
| NCT00002700 | Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia | leukemia;lymphoma | Hydrocortisone (NPC18509) | NP level |
| NCT00002704 | Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia | leukemia | Hydrocortisone (NPC18509) | NP level |
| NCT00002744 | Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia | leukemia | Hydrocortisone (NPC18509) | NP level |
| NCT00002756 | Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia | leukemia | Hydrocortisone (NPC18509) | NP level |
| NCT00002757 | TITLE:Less Intensive Therapy for Children With Non-Hodgkin's Lymphoma | leukemia;lymphoma | Hydrocortisone (NPC18509) | NP level |
| NCT00002760 | Antiandrogen Withdrawal in Treating Patients With Hormone-Refractory Prostate Cancer | prostate cancer | Hydrocortisone (NPC18509) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired adrenocortical insufficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A74.0 |
NCT01847690,NCT01063569
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
NR3C1
|
Acute erythroid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60.35 |
NCT00002798
|
Acute leukaemias of ambiguous lineageDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A61 |
NCT02419755,NCT04898894
|
Acute megakaryoblastic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60.36 |
NCT00002798
|
Acute monocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH9NE2 |
NCT00002798
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1
NCT00002798,NCT03071276,NCT04293562,NCT02270788 |
Acute myelomonocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH78Y4 |
NCT00002798
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adaptive immunity immunodeficiencyDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01 |
NR3C1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
