Collective Molecular Activities of the Plant: Achillea Leptophylla
Plant ID: NPO13746
Plant Latin Name: Achillea Leptophylla
Taxonomy Genus: Achillea
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
282744
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMChina
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
145 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
117 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
30 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC92894
Ingredient ID: NPC90852
Ingredient ID: NPC88733
Ingredient ID: NPC86590
Ingredient ID: NPC86490
Ingredient ID: NPC86451
Ingredient ID: NPC86007
Ingredient ID: NPC85464
Ingredient ID: NPC8138
Ingredient ID: NPC81149
Ingredient ID: NPC77846
Ingredient ID: NPC73774
Ingredient ID: NPC73425
Ingredient ID: NPC71186
Ingredient ID: NPC64377
Ingredient ID: NPC64130
Ingredient ID: NPC62806
Ingredient ID: NPC62128
Ingredient ID: NPC59502
Ingredient ID: NPC58572
Ingredient ID: NPC58388
Ingredient ID: NPC57347
Ingredient ID: NPC52118
Ingredient ID: NPC51400
Ingredient ID: NPC48827
Ingredient ID: NPC45882
Ingredient ID: NPC45383
Ingredient ID: NPC45074
Ingredient ID: NPC44270
Ingredient ID: NPC42700
Ingredient ID: NPC42329
Ingredient ID: NPC4122
Ingredient ID: NPC40302
Ingredient ID: NPC38123
Ingredient ID: NPC37170
Ingredient ID: NPC35994
Ingredient ID: NPC35278
Ingredient ID: NPC34551
Ingredient ID: NPC32969
Ingredient ID: NPC3252
Ingredient ID: NPC32084
Ingredient ID: NPC309821
Ingredient ID: NPC301445
Ingredient ID: NPC300470
Ingredient ID: NPC299939
Ingredient ID: NPC299209
Ingredient ID: NPC29908
Ingredient ID: NPC299
Ingredient ID: NPC297957
Ingredient ID: NPC295865
Ingredient ID: NPC294781
Ingredient ID: NPC289881
Ingredient ID: NPC283741
Ingredient ID: NPC283565
Ingredient ID: NPC281501
Ingredient ID: NPC280829
Ingredient ID: NPC280456
Ingredient ID: NPC275608
Ingredient ID: NPC275147
Ingredient ID: NPC272420
Ingredient ID: NPC270635
Ingredient ID: NPC268500
Ingredient ID: NPC264379
Ingredient ID: NPC264186
Ingredient ID: NPC260218
Ingredient ID: NPC256207
Ingredient ID: NPC256132
Ingredient ID: NPC25378
Ingredient ID: NPC251367
Ingredient ID: NPC25134
Ingredient ID: NPC251000
Ingredient ID: NPC250387
Ingredient ID: NPC249257
Ingredient ID: NPC24901
Ingredient ID: NPC247103
Ingredient ID: NPC236759
Ingredient ID: NPC235838
Ingredient ID: NPC232299
Ingredient ID: NPC230013
Ingredient ID: NPC226981
Ingredient ID: NPC224745
Ingredient ID: NPC224560
Ingredient ID: NPC222276
Ingredient ID: NPC221301
Ingredient ID: NPC217210
Ingredient ID: NPC217189
Ingredient ID: NPC214877
Ingredient ID: NPC214748
Ingredient ID: NPC21387
Ingredient ID: NPC212900
Ingredient ID: NPC21133
Ingredient ID: NPC209122
Ingredient ID: NPC207476
Ingredient ID: NPC205917
Ingredient ID: NPC205672
Ingredient ID: NPC205097
Ingredient ID: NPC204778
Ingredient ID: NPC20194
Ingredient ID: NPC20012
Ingredient ID: NPC199756
Ingredient ID: NPC199383
Ingredient ID: NPC197576
Ingredient ID: NPC196371
Ingredient ID: NPC191194
Ingredient ID: NPC190341
Ingredient ID: NPC175520
Ingredient ID: NPC173511
Ingredient ID: NPC172232
Ingredient ID: NPC17095
Ingredient ID: NPC170894
Ingredient ID: NPC170561
Ingredient ID: NPC169235
Ingredient ID: NPC167953
Ingredient ID: NPC166623
Ingredient ID: NPC16456
Ingredient ID: NPC164508
Ingredient ID: NPC162294
Ingredient ID: NPC162151
Ingredient ID: NPC160066
Ingredient ID: NPC159866
Ingredient ID: NPC156317
Ingredient ID: NPC155807
Ingredient ID: NPC154323
Ingredient ID: NPC153987
Ingredient ID: NPC153580
Ingredient ID: NPC146026
Ingredient ID: NPC145335
Ingredient ID: NPC145047
Ingredient ID: NPC141227
Ingredient ID: NPC140796
Ingredient ID: NPC137922
Ingredient ID: NPC137705
Ingredient ID: NPC13234
Ingredient ID: NPC131940
Ingredient ID: NPC130799
Ingredient ID: NPC12501
Ingredient ID: NPC121729
Ingredient ID: NPC117428
Ingredient ID: NPC116769
Ingredient ID: NPC116216
Ingredient ID: NPC111091
Ingredient ID: NPC108091
Ingredient ID: NPC104608
Ingredient ID: NPC10421
Ingredient ID: NPC104124
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ALOX15
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
ALOX15
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
ALOX15
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
ALOX15
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ALOX15
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
ALOX12
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
ALOX12
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
ALOX15
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
ALOX15
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
ALOX15
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
