CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Jasminum Officinale

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO13180
Plant Latin Name: Jasminum Officinale
Taxonomy Genus: Jasminum
Taxonomy Family: Oleaceae

Plant External Links:

NCBI TaxonomyDB: 126433
Plant-of-the-World-Online: 609672-1

Used in Medicines

Country/Region:

China; Indonesia; India

Traditional Medicine System:

Unani; Indian Folk; TCM; Homeopathy; Ayurveda

Medicinal Functions:

Antiseptic; Antispasmodic; Aphrodisiac; Aromatherapy; Galactogogue; Parasiticide; Tonic

Geographical Distribution

Turkey; Afghanistan; Romania; Nepal; Iran; Bangladesh; Algeria; Cuba; Russia; Indonesia; India; France; Portugal; China; Pakistan; Italy; Dominican Republic; Tajikistan; Haiti

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

67 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

54 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

24 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC9609

Ingredient ID: NPC95460

Ingredient ID: NPC89944

Ingredient ID: NPC8463

Ingredient ID: NPC66868

Ingredient ID: NPC59650

Ingredient ID: NPC58716

Ingredient ID: NPC54172

Ingredient ID: NPC52005

Ingredient ID: NPC45367

Ingredient ID: NPC44931

Ingredient ID: NPC42149

Ingredient ID: NPC38884

Ingredient ID: NPC308289

Ingredient ID: NPC302426

Ingredient ID: NPC299089

Ingredient ID: NPC293588

Ingredient ID: NPC287387

Ingredient ID: NPC283178

Ingredient ID: NPC282116

Ingredient ID: NPC279525

Ingredient ID: NPC274499

Ingredient ID: NPC26937

Ingredient ID: NPC263251

Ingredient ID: NPC261947

Ingredient ID: NPC258104

Ingredient ID: NPC255580

Ingredient ID: NPC255497

Ingredient ID: NPC249616

Ingredient ID: NPC241579

Ingredient ID: NPC224242

Ingredient ID: NPC220518

Ingredient ID: NPC21534

Ingredient ID: NPC215317

Ingredient ID: NPC212591

Ingredient ID: NPC210003

Ingredient ID: NPC20836

Ingredient ID: NPC20505

Ingredient ID: NPC204443

Ingredient ID: NPC204204

Ingredient ID: NPC203891

Ingredient ID: NPC196209

Ingredient ID: NPC192978

Ingredient ID: NPC189142

Ingredient ID: NPC187206

Ingredient ID: NPC183401

Ingredient ID: NPC182277

Ingredient ID: NPC181465

Ingredient ID: NPC176740

Ingredient ID: NPC176728

Ingredient ID: NPC176300

Ingredient ID: NPC169232

Ingredient ID: NPC165287

Ingredient ID: NPC16209

Ingredient ID: NPC160951

Ingredient ID: NPC156222

Ingredient ID: NPC153701

Ingredient ID: NPC136014

Ingredient ID: NPC12529

Ingredient ID: NPC123928

Ingredient ID: NPC115275

Ingredient ID: NPC11433

Ingredient ID: NPC111876

Ingredient ID: NPC110070

Ingredient ID: NPC109594

Ingredient ID: NPC109024

Ingredient ID: NPC101692

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

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Search:

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450	Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450	Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Therapeutic Target	Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Therapeutic Target	Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Therapeutic Target	Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Therapeutic Target	Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Showing 1 to 8 of 8 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	1

Clinical trial details

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Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT01705652	Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients	prostate cancer	Rutin (NPC176740)	NP level

Showing 1 to 1 of 1 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

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Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	AURKB,KDR,AURKA
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	AURKA,KIT,AURKB
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	AURKB,ACHE,AURKA,TSHR
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	AURKB,ACHE,CYP1B1,KIT,AURKA,LMNA
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	AURKA,CYP19A1,AURKB
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	KIT,ACHE,KDR
Bone/articular cartilage neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2F7B	KIT
Brain cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00	KIT,KDR
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	AURKA,CYP19A1,KDR
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	AURKB,CYP19A1,TSHR

Showing 1 to 10 of 96 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Jasminum Officinale

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

67 All known Ingredients in Total

54 Ingredients with Acceptable Bioavailablity

24 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Acute diabete complication

Acute myeloid leukaemia

Adenocarcinoma of bronchus or lung

Adenocarcinoma of pancreas

Adenocarcinoma of stomach

Alzheimer disease

Bone/articular cartilage neoplasm

Brain cancer

Breast cancer

Carcinosarcoma of uterus

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities