CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Asarum Heterotropoides Var. Mandshuricum

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO12468.1
Plant Latin Name: Asarum Heterotropoides Var. Mandshuricum
Taxonomy Genus: Asarum
Taxonomy Family: Aristolochiaceae

Plant External Links:

NCBI TaxonomyDB: 366663
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

44 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

40 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

21 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC90105

Ingredient ID: NPC89422

Ingredient ID: NPC88566

Ingredient ID: NPC86564

Ingredient ID: NPC78551

Ingredient ID: NPC76145

Ingredient ID: NPC71853

Ingredient ID: NPC66704

Ingredient ID: NPC55586

Ingredient ID: NPC51328

Ingredient ID: NPC3649

Ingredient ID: NPC34764

Ingredient ID: NPC315877

Ingredient ID: NPC304208

Ingredient ID: NPC292792

Ingredient ID: NPC287331

Ingredient ID: NPC279508

Ingredient ID: NPC267928

Ingredient ID: NPC257124

Ingredient ID: NPC235901

Ingredient ID: NPC215600

Ingredient ID: NPC214224

Ingredient ID: NPC204120

Ingredient ID: NPC197634

Ingredient ID: NPC19319

Ingredient ID: NPC186903

Ingredient ID: NPC18229

Ingredient ID: NPC180466

Ingredient ID: NPC171928

Ingredient ID: NPC16830

Ingredient ID: NPC165525

Ingredient ID: NPC160416

Ingredient ID: NPC158526

Ingredient ID: NPC154185

Ingredient ID: NPC152618

Ingredient ID: NPC14930

Ingredient ID: NPC141777

Ingredient ID: NPC138113

Ingredient ID: NPC135836

Ingredient ID: NPC129687

Ingredient ID: NPC125935

Ingredient ID: NPC120233

Ingredient ID: NPC119949

Ingredient ID: NPC116003

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Therapeutic Target	Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Therapeutic Target	Transcription factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	4

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT04853082	Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution	Hepatic steatosis	Limonene (NPC76145)	NP level
NCT01119534	Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin	Cough	Eucalyptol (NPC287331)	NP level
NCT04392622	d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma	xerostomia	Limonene (NPC76145)	NP level
NCT05432284	Behavioral Pharmacology of THC and Beta-Myrcene	cannabis dependence	Myrcene (NPC138113)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	TP53,MAPK1,CYP3A4
Pancreatic cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10	TP53,MAPK1
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	TP53,LMNA
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	TP53,LMNA
Melanoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30	MAPK1
Stomach cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72	TP53
Bladder cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94	TP53
Colorectal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B91	TP53
Esophageal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B70	TP53
Brain cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00	TP53
Anxiety Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MB24.3	CYP3A4
Mature B-cell leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A82	TP53
Endometrial cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76	TP53
Malignant haematopoietic neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B33	TP53
Peritoneal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C51	TP53
Ovarian dysfunction Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A80	TP53
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	TP53
Fallopian tube cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C74	TP53
Arteries/arterioles disorder Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD52	MAPK1
Kidney failure Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GB60-GB6Z	TP53
Myelodysplastic syndrome Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A37	TP53
Lip/oral cavity/pharynx neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B6E	TP53
Liposarcoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B59	TP53
Head and neck cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D42	TP53
Ovarian cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73	TP53
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	CYP3A4
Cervical cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C77	TP53
Metastatic liver/bile duct neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D80	TP53
Transplant rejection Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: NE84	TP53
Chronic arterial occlusive disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD4Z	TP53
Xerostomia Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA02.1	NCT04392622
Cannabis use disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C41	NCT05432284
Other specified non-alcoholic fatty liver disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB92.Y	NCT04853082
Cough Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD12	NCT01119534
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	TP53
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	TP53
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	LMNA
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	LMNA
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	LMNA
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	CYP3A4
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	LMNA
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	CYP3A4
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	LMNA
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	CYP3A4
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	MAPK1
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	CYP3A4

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Asarum Heterotropoides Var. Mandshuricum

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

44 All known Ingredients in Total

40 Ingredients with Acceptable Bioavailablity

21 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Solid tumour/cancer

Pancreatic cancer

Malignant neoplasms of biliary tract, distal bile duct

Diffuse large B-cell lymphomas

Melanoma

Stomach cancer

Bladder cancer

Colorectal cancer

Esophageal cancer

Brain cancer

Anxiety

Mature B-cell leukaemia

Endometrial cancer

Malignant haematopoietic neoplasm

Peritoneal cancer

Ovarian dysfunction

Acute myeloid leukaemia

Fallopian tube cancer

Arteries/arterioles disorder

Kidney failure

Myelodysplastic syndrome

Lip/oral cavity/pharynx neoplasm

Liposarcoma

Head and neck cancer

Ovarian cancer

Atopic eczema

Cervical cancer

Metastatic liver/bile duct neoplasm

Transplant rejection

Chronic arterial occlusive disease

Xerostomia

Cannabis use disorder

Other specified non-alcoholic fatty liver disease

Cough

Carcinosarcoma of uterus

Serous cystadenoma,borderline malignancy of ovary

Adenocarcinoma of pancreas

Mesothelioma of pleura

Superficial ovarian endometriosis

Urothelial carcinoma of bladder

Chikungunya virus disease

Malignant neoplasms of thymus

Glioblastoma of brain

Renal cell carcinoma, chromophobe type

Germ cell tumour of testis

Malignant neoplasms of adrenal gland

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities