Collective Molecular Activities of the Plant: Papaver Orientale
Plant ID: NPO12093
Plant Latin Name: Papaver Orientale
Taxonomy Genus: Papaver
Taxonomy Family: Papaveraceae
Plant External Links:
NCBI TaxonomyDB:
22694
Plant-of-the-World-Online:
n.a.
Unknown.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
72 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
8 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
14 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99530
Ingredient ID: NPC9824
Ingredient ID: NPC94975
Ingredient ID: NPC94188
Ingredient ID: NPC93226
Ingredient ID: NPC91014
Ingredient ID: NPC88515
Ingredient ID: NPC80248
Ingredient ID: NPC79715
Ingredient ID: NPC76863
Ingredient ID: NPC7456
Ingredient ID: NPC67441
Ingredient ID: NPC65858
Ingredient ID: NPC64769
Ingredient ID: NPC52277
Ingredient ID: NPC44563
Ingredient ID: NPC44400
Ingredient ID: NPC40857
Ingredient ID: NPC297977
Ingredient ID: NPC296334
Ingredient ID: NPC288494
Ingredient ID: NPC286334
Ingredient ID: NPC282489
Ingredient ID: NPC274791
Ingredient ID: NPC274324
Ingredient ID: NPC273247
Ingredient ID: NPC264633
Ingredient ID: NPC252191
Ingredient ID: NPC250415
Ingredient ID: NPC242473
Ingredient ID: NPC240451
Ingredient ID: NPC236781
Ingredient ID: NPC231607
Ingredient ID: NPC230318
Ingredient ID: NPC227415
Ingredient ID: NPC220397
Ingredient ID: NPC207732
Ingredient ID: NPC204012
Ingredient ID: NPC20145
Ingredient ID: NPC201333
Ingredient ID: NPC200566
Ingredient ID: NPC199459
Ingredient ID: NPC197984
Ingredient ID: NPC194674
Ingredient ID: NPC187583
Ingredient ID: NPC179002
Ingredient ID: NPC177035
Ingredient ID: NPC176224
Ingredient ID: NPC174918
Ingredient ID: NPC172896
Ingredient ID: NPC171069
Ingredient ID: NPC169818
Ingredient ID: NPC160854
Ingredient ID: NPC157574
Ingredient ID: NPC157046
Ingredient ID: NPC153453
Ingredient ID: NPC149634
Ingredient ID: NPC147545
Ingredient ID: NPC14704
Ingredient ID: NPC142718
Ingredient ID: NPC141425
Ingredient ID: NPC140592
Ingredient ID: NPC124336
Ingredient ID: NPC120773
Ingredient ID: NPC118754
Ingredient ID: NPC117482
Ingredient ID: NPC111701
Ingredient ID: NPC108659
Ingredient ID: NPC107485
Ingredient ID: NPC103935
Ingredient ID: NPC102060
Ingredient ID: NPC101100
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
PPARD
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
PPARD
|
Metabolic disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5D2Z |
PPARD
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
PPARD
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
PPARD
|
Autoimmune liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB96 |
PPARD
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PPARD
|
DyslipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80-5C81 |
PPARD
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
PPARD
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
