Collective Molecular Activities of the Plant: Tulipa Gesneriana
Plant ID: NPO11984
Plant Latin Name: Tulipa Gesneriana
Taxonomy Genus: Tulipa
Taxonomy Family: Liliaceae
Plant External Links:
NCBI TaxonomyDB:
13306
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
18 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
12 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
4 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC87135
Ingredient ID: NPC65393
Ingredient ID: NPC55900
Ingredient ID: NPC40805
Ingredient ID: NPC317845
Ingredient ID: NPC307473
Ingredient ID: NPC298695
Ingredient ID: NPC293399
Ingredient ID: NPC287301
Ingredient ID: NPC270070
Ingredient ID: NPC266561
Ingredient ID: NPC251791
Ingredient ID: NPC224313
Ingredient ID: NPC199680
Ingredient ID: NPC179057
Ingredient ID: NPC130329
Ingredient ID: NPC11059
Ingredient ID: NPC100551
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 28 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT02812719 | Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel | freckles | Salicylic Acid (NPC100551) | NP level |
| NCT02352987 | Effect of Neem Extract, Propylene Glycol and Salicylic Acid Combination in the Treatment of Arsenical Palmar Keratosis | heavy metal poisoning | Salicylic Acid (NPC100551) | NP level |
| NCT01228656 | Effectiveness of Association Mometasone Furoate 0.1% and Salicylic Acid 5% Compared With Mometasone Furoate | psoriasis | Salicylic Acid (NPC100551) | NP level |
| NCT00425074 | Pharmacodynamic-pharmacokinetic Trial, of Slow Release ASA, in the Platelet Functionalism. | cardiovascular disease | Salicylic Acid (NPC100551) | NP level |
| NCT01046942 | ThrombElastoGraphic Haemostatic Status and Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery | thrombophilia;thrombotic disease | Salicylic Acid (NPC100551) | NP level |
| NCT00361322 | Efficacy and Safety of a Preparation Containing an Antibiotic and Anti-Inflammatory Agent in Acne Vulgaris | acne | Salicylic Acid (NPC100551) | NP level |
| NCT02755545 | A Clinical Trial to Evaluate the Efficacy of Two Acne Treatments | acne | Salicylic Acid (NPC100551) | NP level |
| NCT02289768 | Study To Evaluate The Efficacy And Safety Of Actikerall® Solution In Patients With Grade I-II Actinic Keratoses | actinic keratosis | Salicylic Acid (NPC100551) | NP level |
| NCT02313909 | Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS) | stroke | Salicylic Acid (NPC100551) | NP level |
| NCT03832647 | Anti-acne Efficacy of a Dermo-cosmetic Product Associated With the Fixed Combination Adapalene 0.1%/ Benzoyl Peroxide 2.5% Treatment Versus This Treatment Associated With a Standard Moisturizer in Male and Female Subjects Presenting With Mild to Moderate Acne | acne | Salicylic Acid (NPC100551) | NP level |
| NCT01294462 | Study to Assess Safety and Efficacy of Ticagrelor (AZD6140) Versus Clopidogrel in Asian/Japanese Patients With Non-ST or ST Elevation Acute Coronary Syndromes (ACS) | acute coronary syndrome | Salicylic Acid (NPC100551) | NP level |
| NCT00501059 | A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease | cardiovascular disease | Salicylic Acid (NPC100551) | NP level |
| NCT01004705 | A Pharmacodynamic Study to Evaluate the Effect of a Fixed Dose Combination Pill on Low Density Lipoprotein (LDL) Cholesterol | Hypercholesterolemia | Salicylic Acid (NPC100551) | NP level |
| NCT03056703 | Bioequivalence of Single Dose Fast Release Aspirin (1000 mg) Tablet Versus Single Dose of Two 500 mg Fast Release Aspirin Tablets | pain | Salicylic Acid (NPC100551) | NP level |
| NCT01914627 | Parallel Group Trial to Evaluate the Efficacy and Safety of Loion® Compared to 10% Salicylic Acid in Patients With Chronic Psoriasis Capitis | psoriasis | Salicylic Acid (NPC100551) | NP level |
| NCT04490967 | Silymarin Cream Versus Salicylic Acid in Treatment of Acne Vulgaris | acne | Salicylic Acid (NPC100551) | NP level |
| NCT01552798 | Efficacy of a Single Dose of Aspirin vs. Acetaminophen in Tension Type Headache | Headache | Salicylic Acid (NPC100551) | NP level |
| NCT01229085 | Efficacy Study of the Combination Mometasone + Salicylic Acid in Patients With Psoriasis | psoriasis | Salicylic Acid (NPC100551) | NP level |
| NCT03503227 | The Value of Prednisolone With Aspirin Before Embryo Transfer in Intracytoplasmic Sperm Injection (ICSI) Cycles | infertility | Salicylic Acid (NPC100551) | NP level |
| NCT01139749 | Efficacy and Safety of Low-dose Oral Isotretinoin for Seborrhea | seborrheic dermatitis | Salicylic Acid (NPC100551) | NP level |
| NCT03447925 | Treatment of Plantar Keratosis With Medicinal Plant in Diabetic Patients | keratosis | Salicylic Acid (NPC100551) | NP level |
| NCT01012349 | Efficacy and Safety Clinical Trial of the Combination of Acetylsalicylic Acid, Sodium Bicarbonate and Citric Acid, Produced by Geolab Pharmaceutical Industries Ltd., Compared to Acetylsalicylic Acid (Aspirin ® - Bayer) in Patients With Episodic Tension-type Headache. | Tension-type headache | Salicylic Acid (NPC100551) | NP level |
| NCT01706250 | U0289-401: Eight Week, Split-face, Study to Determine and Compare the Efficacy and Tolerability of MAXCLARITY™ II to PROACTIV™ | acne | Salicylic Acid (NPC100551) | NP level |
| NCT00501254 | Pharmacodynamic Trial, of Slow Release ASA, in Platelet Functionalism, a Long Term Treatment Period | cardiovascular disease | Salicylic Acid (NPC100551) | NP level |
| NCT02524665 | 8 Week Study to Evaluate and Compare the Efficacy and Tolerability of MAXCLARITY II and MURAD To Treat Acne | acne | Salicylic Acid (NPC100551) | NP level |
| NCT01362218 | Pharmacodynamic Clinical Trial of Cardiovascular Polypill on LDL Cholesterol | Hypercholesterolemia | Salicylic Acid (NPC100551) | NP level |
| NCT01453400 | Evaluate the Time of Pain Relief of Fast Acting Aspirin Versus Acetaminophen in Subjects Diagnosed With Sore Throat Pain | pharyngitis | Salicylic Acid (NPC100551) | NP level |
| NCT01706263 | U0289-402: An Open Label, 8 Week Study to Evaluate the Efficacy and Tolerability of MAXCLARITY II in Subjects With Acne | acne | Salicylic Acid (NPC100551) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT04490967,NCT02524665,NCT00361322,NCT03832647,NCT01706263,NCT02755545,NCT01706250
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
NCT00501059,NCT00501254,NCT00425074
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
NCT01228656,NCT01914627,NCT01229085
|
HypercholesterolaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80.0 |
NCT01004705,NCT01362218
|
Tension-type headacheDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A81 |
NCT01012349,NCT01552798
|
NasopharyngitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA00 |
NCT01453400
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
NCT01139749
|
Keratosis pilarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED56 |
NCT03447925
|
FrecklesDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED61.0 |
NCT02812719
|
Deep vein thrombosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD71 |
NCT01046942
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
NCT03056703
|
Harmful effects of drugs, medicaments or biological substances, not elsewhere classifiedDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE60 |
NCT02352987
|
Male infertilityDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB04 |
NCT03503227
|
ThrombophiliaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B61 |
NCT01046942
|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT02289768
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT01294462
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
NCT02313909
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
NAPRT
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
