CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Ruscus Hypoglossum

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO11950
Plant Latin Name: Ruscus Hypoglossum
Taxonomy Genus: Ruscus
Taxonomy Family: Asparagaceae

Plant External Links:

NCBI TaxonomyDB: 191652
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:

Turkey

Traditional Medicine System:

Geographical Distribution

Turkey

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

54 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

1 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

5 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC94796

Ingredient ID: NPC93075

Ingredient ID: NPC93020

Ingredient ID: NPC86668

Ingredient ID: NPC40089

Ingredient ID: NPC39379

Ingredient ID: NPC3245

Ingredient ID: NPC296677

Ingredient ID: NPC294457

Ingredient ID: NPC29172

Ingredient ID: NPC285154

Ingredient ID: NPC281428

Ingredient ID: NPC280547

Ingredient ID: NPC271086

Ingredient ID: NPC264425

Ingredient ID: NPC264317

Ingredient ID: NPC262649

Ingredient ID: NPC256546

Ingredient ID: NPC253773

Ingredient ID: NPC251641

Ingredient ID: NPC249014

Ingredient ID: NPC244702

Ingredient ID: NPC240340

Ingredient ID: NPC236607

Ingredient ID: NPC225629

Ingredient ID: NPC210537

Ingredient ID: NPC210234

Ingredient ID: NPC209611

Ingredient ID: NPC205513

Ingredient ID: NPC192403

Ingredient ID: NPC189689

Ingredient ID: NPC188727

Ingredient ID: NPC18825

Ingredient ID: NPC186941

Ingredient ID: NPC182107

Ingredient ID: NPC179174

Ingredient ID: NPC170838

Ingredient ID: NPC166924

Ingredient ID: NPC164858

Ingredient ID: NPC164158

Ingredient ID: NPC158329

Ingredient ID: NPC157297

Ingredient ID: NPC15439

Ingredient ID: NPC147116

Ingredient ID: NPC145040

Ingredient ID: NPC144462

Ingredient ID: NPC14148

Ingredient ID: NPC131190

Ingredient ID: NPC120559

Ingredient ID: NPC115062

Ingredient ID: NPC114031

Ingredient ID: NPC109868

Ingredient ID: NPC10321

Ingredient ID: NPC101428

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Nuclear hormone receptor subfamily 1	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Therapeutic Target	Other cytosolic protein	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361
Therapeutic Target	Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	2

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00701987	Safety, Tolerability, and Preliminary Efficacy Study of ALS-357 in Patients With Cutaneous Metastatic Melanoma	melanoma	Betulinic Acid (NPC264317)	NP level
NCT00346502	Evaluation of 20% Betulinic Acid Ointment for Treatment of Dysplastic Nevi (Moderate to Severe Dysplasia)	dysplastic nevus	Betulinic Acid (NPC264317)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Melanoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30	MCL1 NCT00701987
Mastocytosis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A21	MCL1
Multiple myeloma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A83	MCL1
Lung cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25	MCL1
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	MCL1
Postoperative inflammation Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-CA43	PTPN1
Malignant intestine neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C0Z	MCL1
Myeloproliferative neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A20	MCL1
Malignant haematopoietic neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B33	MCL1
Mature B-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A85	MCL1
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	MCL1
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	PTPN1
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	PTPN1
Ophthalmic devices/implants/grafts injury Disease Category: 23.External causes of morbidity or mortality Disease ICD-11 Code: PK97	PTPN1
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	PTPN1
Metabolic disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C50-5D2Z	PTPN1
Obesity Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B80-5B81	PTPN1
Dysplastic naevus Disease Category: X.Extension Codes Disease ICD-11 Code: XH9035	NCT00346502
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	PTPN1
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	PTPN1
West Nile virus infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D46	MCL1
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	PTPN1
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	MCL1
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	MCL1

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Ruscus Hypoglossum

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

54 All known Ingredients in Total

1 Ingredients with Acceptable Bioavailablity

5 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Melanoma

Mastocytosis

Multiple myeloma

Lung cancer

Solid tumour/cancer

Postoperative inflammation

Malignant intestine neoplasm

Myeloproliferative neoplasm

Malignant haematopoietic neoplasm

Mature B-cell lymphoma

Acute myeloid leukaemia

Acute diabete complication

Breast cancer

Ophthalmic devices/implants/grafts injury

Type 2 diabetes mellitus

Metabolic disorder

Obesity

Dysplastic naevus

Leishmaniasis

Diffuse large B-cell lymphomas

West Nile virus infection

Adenocarcinoma of pancreas

Superficial ovarian endometriosis

Glioblastoma of brain

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities