Collective Molecular Activities of the Plant: Elaeagnus Commutata
Unknown.
Canada; United States
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
141 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
62 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
52 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97534
Ingredient ID: NPC93201
Ingredient ID: NPC92319
Ingredient ID: NPC89909
Ingredient ID: NPC88584
Ingredient ID: NPC88354
Ingredient ID: NPC83425
Ingredient ID: NPC81831
Ingredient ID: NPC78441
Ingredient ID: NPC77625
Ingredient ID: NPC75441
Ingredient ID: NPC74017
Ingredient ID: NPC72447
Ingredient ID: NPC71690
Ingredient ID: NPC69513
Ingredient ID: NPC68426
Ingredient ID: NPC64190
Ingredient ID: NPC51700
Ingredient ID: NPC49074
Ingredient ID: NPC48128
Ingredient ID: NPC41481
Ingredient ID: NPC40394
Ingredient ID: NPC39730
Ingredient ID: NPC39602
Ingredient ID: NPC37649
Ingredient ID: NPC37087
Ingredient ID: NPC33103
Ingredient ID: NPC32311
Ingredient ID: NPC31187
Ingredient ID: NPC309066
Ingredient ID: NPC308489
Ingredient ID: NPC307063
Ingredient ID: NPC307050
Ingredient ID: NPC304962
Ingredient ID: NPC304905
Ingredient ID: NPC293908
Ingredient ID: NPC293664
Ingredient ID: NPC292705
Ingredient ID: NPC29157
Ingredient ID: NPC290598
Ingredient ID: NPC289774
Ingredient ID: NPC287430
Ingredient ID: NPC287063
Ingredient ID: NPC285965
Ingredient ID: NPC285951
Ingredient ID: NPC284288
Ingredient ID: NPC283389
Ingredient ID: NPC283184
Ingredient ID: NPC280576
Ingredient ID: NPC279886
Ingredient ID: NPC27790
Ingredient ID: NPC277458
Ingredient ID: NPC27377
Ingredient ID: NPC272824
Ingredient ID: NPC270043
Ingredient ID: NPC268794
Ingredient ID: NPC267856
Ingredient ID: NPC265077
Ingredient ID: NPC264317
Ingredient ID: NPC261933
Ingredient ID: NPC26029
Ingredient ID: NPC248830
Ingredient ID: NPC248747
Ingredient ID: NPC248521
Ingredient ID: NPC248355
Ingredient ID: NPC248132
Ingredient ID: NPC242733
Ingredient ID: NPC241943
Ingredient ID: NPC241427
Ingredient ID: NPC237875
Ingredient ID: NPC232673
Ingredient ID: NPC231810
Ingredient ID: NPC23060
Ingredient ID: NPC230124
Ingredient ID: NPC228383
Ingredient ID: NPC227467
Ingredient ID: NPC225467
Ingredient ID: NPC220825
Ingredient ID: NPC219876
Ingredient ID: NPC219205
Ingredient ID: NPC217635
Ingredient ID: NPC215833
Ingredient ID: NPC215072
Ingredient ID: NPC214243
Ingredient ID: NPC212556
Ingredient ID: NPC211230
Ingredient ID: NPC209846
Ingredient ID: NPC201459
Ingredient ID: NPC196238
Ingredient ID: NPC194882
Ingredient ID: NPC194251
Ingredient ID: NPC193210
Ingredient ID: NPC189417
Ingredient ID: NPC1890
Ingredient ID: NPC18872
Ingredient ID: NPC185977
Ingredient ID: NPC18536
Ingredient ID: NPC185045
Ingredient ID: NPC184613
Ingredient ID: NPC179256
Ingredient ID: NPC178383
Ingredient ID: NPC176679
Ingredient ID: NPC174205
Ingredient ID: NPC173790
Ingredient ID: NPC173501
Ingredient ID: NPC171434
Ingredient ID: NPC169497
Ingredient ID: NPC168615
Ingredient ID: NPC167317
Ingredient ID: NPC164365
Ingredient ID: NPC161875
Ingredient ID: NPC158168
Ingredient ID: NPC152384
Ingredient ID: NPC147124
Ingredient ID: NPC145876
Ingredient ID: NPC145009
Ingredient ID: NPC142990
Ingredient ID: NPC142754
Ingredient ID: NPC142415
Ingredient ID: NPC137037
Ingredient ID: NPC136099
Ingredient ID: NPC13114
Ingredient ID: NPC129228
Ingredient ID: NPC126029
Ingredient ID: NPC124492
Ingredient ID: NPC123965
Ingredient ID: NPC123463
Ingredient ID: NPC123324
Ingredient ID: NPC121162
Ingredient ID: NPC120968
Ingredient ID: NPC118971
Ingredient ID: NPC11724
Ingredient ID: NPC114590
Ingredient ID: NPC105863
Ingredient ID: NPC105189
Ingredient ID: NPC103754
Ingredient ID: NPC103647
Ingredient ID: NPC103082
Ingredient ID: NPC101475
Ingredient ID: NPC100702
Ingredient ID: NPC100127
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Therapeutic Target | Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| Therapeutic Target | Surface antigen | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
| Therapeutic Target | Transcription factor | RELA | Nuclear factor NF-kappa-B p65 subunit | Q04206 | CHEMBL5533 |
| Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 8 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00346502 | Evaluation of 20% Betulinic Acid Ointment for Treatment of Dysplastic Nevi (Moderate to Severe Dysplasia) | dysplastic nevus | Betulinic Acid (NPC264317) | NP level |
| NCT00701987 | Safety, Tolerability, and Preliminary Efficacy Study of ALS-357 in Patients With Cutaneous Metastatic Melanoma | melanoma | Betulinic Acid (NPC264317) | NP level |
| NCT01856868 | Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study) | Becker muscular dystrophy | (-)-Epicatechin (NPC126029) | NP level |
| NCT01880866 | (-)-Epicatechin and Pulmonary Arterial Hypertension | pulmonary arterial hypertension | (-)-Epicatechin (NPC126029) | NP level |
| NCT02337933 | Effect of Ursolic Acid Administration on Insulin Sensitivity and Metabolic Syndrome | metabolic syndrome | Ursolic Acid (NPC51700) | NP level |
| NCT03216876 | A Study Of Ursolic Acid For Primary Sclerosing Cholangitis | sclerosing cholangitis | Ursolic Acid (NPC51700) | NP level |
| NCT03236662 | (-)- Epicatechin Becker Muscular Dystrophy | Becker muscular dystrophy | (-)-Epicatechin (NPC126029) | NP level |
| NCT04403568 | Testing the Synergism of Phytonutrients, Curcumin and Ursolic Acid, to Target Molecular Pathways in the Prostate | prostate cancer | Ursolic Acid (NPC51700) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PTPN1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
RELA,NFKB1,PTPRC
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1,RELA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
AKR1B10
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
SNCA,AKR1B10,PTPRC,PTPN1,CDC25B,RECQL,CES1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CDC25B
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
SNCA
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
RELA,NFKB1
|
Autoimmune diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40-4A45 |
RORC
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
