Collective Molecular Activities of the Plant: Callitris Macleayana
Unknown.
Australia
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
97 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
96 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
9 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99486
Ingredient ID: NPC9440
Ingredient ID: NPC91216
Ingredient ID: NPC83264
Ingredient ID: NPC81805
Ingredient ID: NPC79417
Ingredient ID: NPC75643
Ingredient ID: NPC6875
Ingredient ID: NPC6527
Ingredient ID: NPC65043
Ingredient ID: NPC63743
Ingredient ID: NPC61872
Ingredient ID: NPC61533
Ingredient ID: NPC5441
Ingredient ID: NPC51265
Ingredient ID: NPC50413
Ingredient ID: NPC50125
Ingredient ID: NPC46446
Ingredient ID: NPC45940
Ingredient ID: NPC44122
Ingredient ID: NPC40065
Ingredient ID: NPC39488
Ingredient ID: NPC36363
Ingredient ID: NPC35802
Ingredient ID: NPC33259
Ingredient ID: NPC311422
Ingredient ID: NPC309135
Ingredient ID: NPC306215
Ingredient ID: NPC299703
Ingredient ID: NPC29890
Ingredient ID: NPC29864
Ingredient ID: NPC294836
Ingredient ID: NPC294494
Ingredient ID: NPC290443
Ingredient ID: NPC285881
Ingredient ID: NPC285265
Ingredient ID: NPC284238
Ingredient ID: NPC281768
Ingredient ID: NPC276738
Ingredient ID: NPC275148
Ingredient ID: NPC273820
Ingredient ID: NPC271977
Ingredient ID: NPC271298
Ingredient ID: NPC270831
Ingredient ID: NPC270569
Ingredient ID: NPC269429
Ingredient ID: NPC267727
Ingredient ID: NPC266940
Ingredient ID: NPC266712
Ingredient ID: NPC26574
Ingredient ID: NPC26431
Ingredient ID: NPC261405
Ingredient ID: NPC259315
Ingredient ID: NPC257421
Ingredient ID: NPC253165
Ingredient ID: NPC253090
Ingredient ID: NPC248182
Ingredient ID: NPC243860
Ingredient ID: NPC241081
Ingredient ID: NPC23765
Ingredient ID: NPC236709
Ingredient ID: NPC235292
Ingredient ID: NPC229622
Ingredient ID: NPC228433
Ingredient ID: NPC226169
Ingredient ID: NPC225665
Ingredient ID: NPC225507
Ingredient ID: NPC224651
Ingredient ID: NPC223461
Ingredient ID: NPC218410
Ingredient ID: NPC216333
Ingredient ID: NPC216267
Ingredient ID: NPC216081
Ingredient ID: NPC214535
Ingredient ID: NPC211579
Ingredient ID: NPC208486
Ingredient ID: NPC201856
Ingredient ID: NPC201399
Ingredient ID: NPC193238
Ingredient ID: NPC186422
Ingredient ID: NPC177676
Ingredient ID: NPC176874
Ingredient ID: NPC175308
Ingredient ID: NPC165122
Ingredient ID: NPC163021
Ingredient ID: NPC159789
Ingredient ID: NPC152195
Ingredient ID: NPC14208
Ingredient ID: NPC135046
Ingredient ID: NPC133922
Ingredient ID: NPC132840
Ingredient ID: NPC125575
Ingredient ID: NPC118736
Ingredient ID: NPC108896
Ingredient ID: NPC105224
Ingredient ID: NPC103267
Ingredient ID: NPC102759
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 10 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT02634801 | A Study of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque Psoriasis Naive to Systemic Treatment | psoriasis | Fumaric Acid (NPC224651) | NP level |
| NCT02474082 | Study of Secukinumab Compared to Fumaderm® in Adults With Moderate to Severe Psoriasis. | psoriasis | Fumaric Acid (NPC224651) | NP level |
| NCT05362500 | Comparison of Chemical Peeling Agent With Transamine for Treatment of Melasma | freckles | Glycolic Acid (NPC165122) | NP level |
| NCT02126657 | The Efficacy and Safety of a Single 70% Glycolic Acid Peel With Vitamin C for the Treatment of Acne Scars | acne | Glycolic Acid (NPC165122) | NP level |
| NCT02951533 | A Study to Compare the Efficacy of Guselkumab to Fumaric Acid Esters for the Treatment of Participants With Moderate to Severe Plaque Psoriasis | psoriasis | Fumaric Acid (NPC224651) | NP level |
| NCT02812719 | Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel | freckles | Glycolic Acid (NPC165122) | NP level |
| NCT01985321 | Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for the Treatment of Cold Sores | Herpes Labialis | Glycolic Acid (NPC165122) | NP level |
| NCT01352988 | Efficacy and Safety of Fumaric Acid Esters (Fumaderm®) in the Treatment of Patients With Cutaneous Lupus Erythematosus | cutaneous lupus erythematosus | Fumaric Acid (NPC224651) | NP level |
| NCT01321164 | Fumaric Acid Versus Fumaric Acid Plus Narrow Band Type B Ultraviolet (UVB) for Psoriasis | psoriasis | Fumaric Acid (NPC224651) | NP level |
| NCT04649203 | Cytoflavin in the Treatment of Patients With Diabetic Polyneuropathy | diabetic neuropathy | Succinic Acid (NPC236709) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
NCT02951533,NCT02474082,NCT02634801,NCT01321164
|
FrecklesDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED61.0 |
NCT02812719,NCT05362500
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT02126657
|
Cutaneous lupus erythematosusDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EB50-EB5Z |
NCT01352988
|
Diabetic polyneuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C03.0 |
NCT04649203
|
Herpes simplex labialisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00.01 |
NCT01985321
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
LMNA
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
LMNA
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
