Collective Molecular Activities of the Plant: Impatiens Balsamina
Country/Region:
Turkey; Indonesia; India; China; Thailand; South KoreaTraditional Medicine System:
Indian Folk; TCM; Unani; Ayurveda; SiddhaMedicinal Functions:
Antibiotic; Cancer; Cathartic; Diuretic; Emetic; Expectorant; Poultice; Tonic; Warts
Turkey; Bangladesh; France; Cameroon; Ecuador; Benin; Cuba; Venezuela; United States; China; Thailand; Dominican Republic; Oman; Tanzania; Indonesia; New Caledonia; Mauritius; Trinidad and Tobago; Haiti; Jamaica; Honduras; Mexico; South Africa; India; Austria; Mozambique; Sri Lanka; Kenya; South Korea; Nicaragua
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
51 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
22 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
25 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99912
Ingredient ID: NPC88450
Ingredient ID: NPC5204
Ingredient ID: NPC483160
Ingredient ID: NPC483159
Ingredient ID: NPC483158
Ingredient ID: NPC483157
Ingredient ID: NPC38059
Ingredient ID: NPC33373
Ingredient ID: NPC324572
Ingredient ID: NPC317973
Ingredient ID: NPC303141
Ingredient ID: NPC302455
Ingredient ID: NPC29666
Ingredient ID: NPC295918
Ingredient ID: NPC285288
Ingredient ID: NPC279081
Ingredient ID: NPC272068
Ingredient ID: NPC270898
Ingredient ID: NPC258957
Ingredient ID: NPC257642
Ingredient ID: NPC257447
Ingredient ID: NPC255626
Ingredient ID: NPC250069
Ingredient ID: NPC244443
Ingredient ID: NPC242307
Ingredient ID: NPC239632
Ingredient ID: NPC228523
Ingredient ID: NPC221404
Ingredient ID: NPC21543
Ingredient ID: NPC20791
Ingredient ID: NPC19721
Ingredient ID: NPC190454
Ingredient ID: NPC185498
Ingredient ID: NPC181465
Ingredient ID: NPC179950
Ingredient ID: NPC176740
Ingredient ID: NPC164802
Ingredient ID: NPC164778
Ingredient ID: NPC15611
Ingredient ID: NPC156021
Ingredient ID: NPC150512
Ingredient ID: NPC138233
Ingredient ID: NPC135092
Ingredient ID: NPC133671
Ingredient ID: NPC129165
Ingredient ID: NPC127624
Ingredient ID: NPC116775
Ingredient ID: NPC112552
Ingredient ID: NPC110899
Ingredient ID: NPC102809
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Therapeutic Target | Enzyme | NOS3 | Nitric-oxide synthase, endothelial | P29474 | CHEMBL4803 |
| Therapeutic Target | Enzyme | NOS1 | Nitric-oxide synthase, brain | P29475 | CHEMBL3568 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Histone acetyltransferase | NCOA3 | Nuclear receptor coactivator 3 | Q9Y6Q9 | CHEMBL1615382 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 1008 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000660 | Phase I Study of Weekly Oral VP-16 for AIDS-Associated Kaposi's Sarcoma | Kaposi's sarcoma | Etoposide (NPC185498) | NP level |
| NCT00001339 | A Study of Combination Chemotherapy and Surgical Resection in the Treatment of Adrenocortical Carcinoma: Continuous Infusion Doxorubicin, Vincristine and Etoposide With Daily Mitotane Before and After Surgical Resection | carcinoma | Etoposide (NPC185498) | NP level |
| NCT00001563 | EPOCH Chemotherapy +/- IL-12 for Previously Untreated and EPOCH Plus Rituximab for Previously Treated Patients With AIDS-Associated Lymphoma | Lymphoma, AIDS-Related | Etoposide (NPC185498) | NP level |
| NCT00002461 | Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Refractory Hodgkin's Disease or Non-Hodgkin's Lymphoma | lymphoma | Etoposide (NPC185498) | NP level |
| NCT00002471 | Combination Chemotherapy in Treating Patients With Acute B-Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma | leukemia;lymphoma | Etoposide (NPC185498) | NP level |
| NCT00002481 | Combination Chemotherapy and Radiation Therapy Plus Bone Marrow Transplantation in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma | lymphoma | Etoposide (NPC185498) | NP level |
| NCT00002488 | Combination Chemotherapy in Treating Patients With Intermediate-Grade or High-Grade Non-Hodgkin's Lymphoma Who Have Not Responded to Anthracycline-Containing Combination Chemotherapy | lymphoma | Etoposide (NPC185498) | NP level |
| NCT00002494 | Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia | leukemia;lymphoma | Etoposide (NPC185498) | NP level |
| NCT00002509 | High-Dose Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Poor-Prognosis Breast Cancer | breast cancer | Etoposide (NPC185498) | NP level |
| NCT00002510 | Chemotherapy and Radiation Therapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Non-Hodgkin's Lymphoma | lymphoma | Etoposide (NPC185498) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acute basophilic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60.37 |
NCT00369317,NCT00006363
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4,AURKB,KDR
|
Acute erythroid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60.35 |
NCT00006363,NCT00002798,NCT00003190,NCT00369317
|
Acute megakaryoblastic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60.36 |
NCT00002798,NCT00003190,NCT00369317,NCT00006363
|
Acute monocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH9NE2 |
NCT00369317,NCT00003190,NCT00002798,NCT00006363
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TOP2B,FLT3,IDO1,AURKB,PIM1,SRC,AXL,KDM1A,TP53
NCT03182244,NCT03591510,NCT02848183,NCT01830777,NCT03793478,NCT00703820,NCT02632708,NCT01237808,NCT00774046,NCT00660036,NCT02400281,NCT02306291,NCT03164057,NCT00002798,NCT01025778,NCT02638428,NCT01411267,NCT00079482,NCT01677949,NCT00151255,NCT00939653,NCT04326439,NCT02070458,NCT00315705,NCT00151242,NCT02773732,NCT03118466,NCT02626338,NCT02039726,NCT00003190,NCT01681537,NCT00136084,NCT01180322,NCT01027923,NCT02631252,NCT00512252,NCT04293562,NCT00146120,NCT02349178,NCT03926624,NCT02421939,NCT03504410,NCT00906945,NCT00880243,NCT00006363,NCT00780104,NCT03839446,NCT00186966,NCT00003190,NCT01729845,NCT03860844,NCT03568994,NCT00369317 |
Acute myelomonocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH78Y4 |
NCT00002798,NCT00003190,NCT00006363,NCT00369317
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CDK1,NPSR1,CA7,XDH,CYP2C9,AURKB,ACHE,CA12
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
