Collective Molecular Activities of the Plant: Melissa Officinalis
Plant ID: NPO10932
Plant Latin Name: Melissa Officinalis
Taxonomy Genus: Melissa
Taxonomy Family: Lamiaceae
Plant External Links:
NCBI TaxonomyDB:
39338
Plant-of-the-World-Online:
n.a.
Country/Region:
Turkey; Israel; Italy; Portugal; India; Jordan; Chile; China; ArgentinaTraditional Medicine System:
TCM; SiddhaMedicinal Functions:
Antianxiety; Antibacterial; Antidepressant; Antiemetic; Antispasmodic; Antiviral; Aromatherapy; Carminative; Diaphoretic; Digestive; Emmenagogue; Febrifuge; Sedative; Tonic
Turkey; Israel; Italy; Portugal; India; China; Chile; Jordan; Argentina
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
61 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
45 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
33 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99734
Ingredient ID: NPC96693
Ingredient ID: NPC96218
Ingredient ID: NPC88566
Ingredient ID: NPC79576
Ingredient ID: NPC7314
Ingredient ID: NPC72285
Ingredient ID: NPC67508
Ingredient ID: NPC64176
Ingredient ID: NPC61769
Ingredient ID: NPC61615
Ingredient ID: NPC61
Ingredient ID: NPC490023
Ingredient ID: NPC489986
Ingredient ID: NPC489970
Ingredient ID: NPC489886
Ingredient ID: NPC477515
Ingredient ID: NPC471628
Ingredient ID: NPC34764
Ingredient ID: NPC331182
Ingredient ID: NPC313107
Ingredient ID: NPC312800
Ingredient ID: NPC308749
Ingredient ID: NPC29883
Ingredient ID: NPC294902
Ingredient ID: NPC289366
Ingredient ID: NPC286774
Ingredient ID: NPC282694
Ingredient ID: NPC276009
Ingredient ID: NPC274584
Ingredient ID: NPC265305
Ingredient ID: NPC255042
Ingredient ID: NPC254156
Ingredient ID: NPC24824
Ingredient ID: NPC243728
Ingredient ID: NPC242580
Ingredient ID: NPC239952
Ingredient ID: NPC235625
Ingredient ID: NPC230301
Ingredient ID: NPC226897
Ingredient ID: NPC223455
Ingredient ID: NPC22098
Ingredient ID: NPC216407
Ingredient ID: NPC202189
Ingredient ID: NPC198658
Ingredient ID: NPC197356
Ingredient ID: NPC19488
Ingredient ID: NPC190771
Ingredient ID: NPC182840
Ingredient ID: NPC18205
Ingredient ID: NPC175987
Ingredient ID: NPC165651
Ingredient ID: NPC162742
Ingredient ID: NPC157414
Ingredient ID: NPC151620
Ingredient ID: NPC142415
Ingredient ID: NPC138113
Ingredient ID: NPC122962
Ingredient ID: NPC120926
Ingredient ID: NPC109838
Ingredient ID: NPC105246
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2B6 | Cytochrome P450 2B6 | P20813 | CHEMBL4729 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A2 | Norepinephrine transporter | P23975 | CHEMBL222 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A4 | Serotonin transporter | P31645 | CHEMBL228 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A3 | Dopamine transporter | Q01959 | CHEMBL238 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
| Therapeutic Target | Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
| Therapeutic Target | Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 38 | |
 Plant level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00005574 | Gentamicin Treatment of Muscular Dystrophy | Becker muscular dystrophy;Duchenne muscular dystrophy | Gentamicin (NPC471628) | NP level |
| NCT00128466 | Treatment and Diagnosis of Plague | Yersinia pestis infectious disease | Gentamicin (NPC471628) | NP level |
| NCT00189384 | Efficacy Study of Community-Based Treatment of Serious Bacterial Infections in Young Infants | Sepsis;bacterial disease | Gentamicin (NPC471628) | NP level |
| NCT00376428 | Interest of Gentamicin-induced Readthrough in Cystic Fibrosis Patients | cystic fibrosis | Gentamicin (NPC471628) | NP level |
| NCT00451074 | Six Month Study of Gentamicin in Duchenne Muscular Dystrophy With Stop Codons | Duchenne muscular dystrophy | Gentamicin (NPC471628) | NP level |
| NCT00593567 | Safety and Efficacy of an Antibiotic Sponge in Diabetic Patients With a Mild Infection of a Foot Ulcer | diabetic foot | Gentamicin (NPC471628) | NP level |
| NCT00600483 | Safety and Efficacy of an Antibiotic Implant in Cardiac Surgical Subjects at Higher Risk for Sternal Wound Infection | infection | Gentamicin (NPC471628) | NP level |
| NCT00600925 | A Study of an Antibiotic Implant in General Surgical Subjects at Higher Risk for Surgical Wound Infection | infection | Gentamicin (NPC471628) | NP level |
| NCT00657917 | Topical Treatment of Recalcitrant Ulcerative Old World Leishmaniasis With WR 279,396 | cutaneous Leishmaniasis | Gentamicin (NPC471628) | NP level |
| NCT00658957 | Prevention of Infection Using a Topical Gentamicin-Collagen Sponge in Diabetic Patients With An Uninfected Foot Ulcer | diabetic foot | Gentamicin (NPC471628) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2,ESR1
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PTPN1,NR3C1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
PTPRC,NFKB1
|
Acute painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG31 |
SLC6A2
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adaptive immunity immunodeficiencyDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01 |
NR3C1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
SLC6A3,MMP1,CYP2B6,MMP9,AKR1B10,F2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
