CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Pelargonium Zonale

Example Image

PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO10695
Plant Latin Name: Pelargonium Zonale
Taxonomy Genus: Pelargonium
Taxonomy Family: Geraniaceae

Plant External Links:

NCBI TaxonomyDB: 4032
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:

Brazil

Traditional Medicine System:

Medicinal Functions:

Astringent

Geographical Distribution

Brazil; Mexico; Cuba; Cape Verde; South Africa; Morocco; Trinidad and Tobago; Dominican Republic; Haiti; Spain

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

71 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

6 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

14 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC99530

Ingredient ID: NPC9824

Ingredient ID: NPC94975

Ingredient ID: NPC94188

Ingredient ID: NPC93226

Ingredient ID: NPC91014

Ingredient ID: NPC88515

Ingredient ID: NPC82988

Ingredient ID: NPC8094

Ingredient ID: NPC80248

Ingredient ID: NPC79715

Ingredient ID: NPC76863

Ingredient ID: NPC7456

Ingredient ID: NPC67441

Ingredient ID: NPC65858

Ingredient ID: NPC64769

Ingredient ID: NPC52277

Ingredient ID: NPC44563

Ingredient ID: NPC44400

Ingredient ID: NPC297977

Ingredient ID: NPC296334

Ingredient ID: NPC288494

Ingredient ID: NPC286334

Ingredient ID: NPC282489

Ingredient ID: NPC274324

Ingredient ID: NPC273247

Ingredient ID: NPC264633

Ingredient ID: NPC252191

Ingredient ID: NPC250415

Ingredient ID: NPC242473

Ingredient ID: NPC240451

Ingredient ID: NPC236781

Ingredient ID: NPC231607

Ingredient ID: NPC230318

Ingredient ID: NPC227415

Ingredient ID: NPC220397

Ingredient ID: NPC207732

Ingredient ID: NPC204012

Ingredient ID: NPC20145

Ingredient ID: NPC201333

Ingredient ID: NPC200566

Ingredient ID: NPC199459

Ingredient ID: NPC197984

Ingredient ID: NPC194674

Ingredient ID: NPC18980

Ingredient ID: NPC187583

Ingredient ID: NPC179002

Ingredient ID: NPC177035

Ingredient ID: NPC176224

Ingredient ID: NPC174918

Ingredient ID: NPC172896

Ingredient ID: NPC171069

Ingredient ID: NPC169818

Ingredient ID: NPC160854

Ingredient ID: NPC157574

Ingredient ID: NPC157046

Ingredient ID: NPC153453

Ingredient ID: NPC149634

Ingredient ID: NPC147545

Ingredient ID: NPC14704

Ingredient ID: NPC142718

Ingredient ID: NPC141425

Ingredient ID: NPC140592

Ingredient ID: NPC120773

Ingredient ID: NPC118754

Ingredient ID: NPC117482

Ingredient ID: NPC111701

Ingredient ID: NPC108659

Ingredient ID: NPC103935

Ingredient ID: NPC102060

Ingredient ID: NPC101100

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	PPARD
Non-alcoholic fatty liver disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB92	PPARD
Dyslipidemia Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C80-5C81	PPARD
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	PPARD
Autoimmune liver disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB96	PPARD
Metabolic disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C50-5D2Z	PPARD
Hyper-lipoproteinaemia Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C80	PPARD
Obesity Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B80-5B81	PPARD
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	PPARD

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Pelargonium Zonale

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

71 All known Ingredients in Total

6 Ingredients with Acceptable Bioavailablity

14 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Type 2 diabetes mellitus

Non-alcoholic fatty liver disease

Dyslipidemia

Alzheimer disease

Autoimmune liver disease

Metabolic disorder

Hyper-lipoproteinaemia

Obesity

Adenocarcinoma of pancreas

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities