Collective Molecular Activities of the Plant: Othonna Cylindrica
Plant ID: NPO10595
Plant Latin Name: Othonna Cylindrica
Taxonomy Genus: Othonna
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
97 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
96 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
9 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99486
Ingredient ID: NPC9440
Ingredient ID: NPC91216
Ingredient ID: NPC83264
Ingredient ID: NPC81805
Ingredient ID: NPC79417
Ingredient ID: NPC75643
Ingredient ID: NPC6875
Ingredient ID: NPC6527
Ingredient ID: NPC65043
Ingredient ID: NPC63743
Ingredient ID: NPC61872
Ingredient ID: NPC61533
Ingredient ID: NPC5441
Ingredient ID: NPC51265
Ingredient ID: NPC50413
Ingredient ID: NPC50125
Ingredient ID: NPC46446
Ingredient ID: NPC45940
Ingredient ID: NPC44122
Ingredient ID: NPC40065
Ingredient ID: NPC39488
Ingredient ID: NPC36363
Ingredient ID: NPC35802
Ingredient ID: NPC33259
Ingredient ID: NPC311422
Ingredient ID: NPC309135
Ingredient ID: NPC306215
Ingredient ID: NPC299703
Ingredient ID: NPC29890
Ingredient ID: NPC29864
Ingredient ID: NPC294836
Ingredient ID: NPC294494
Ingredient ID: NPC290443
Ingredient ID: NPC285881
Ingredient ID: NPC285265
Ingredient ID: NPC284238
Ingredient ID: NPC281768
Ingredient ID: NPC276738
Ingredient ID: NPC275148
Ingredient ID: NPC273820
Ingredient ID: NPC271977
Ingredient ID: NPC271298
Ingredient ID: NPC270831
Ingredient ID: NPC270569
Ingredient ID: NPC269429
Ingredient ID: NPC267727
Ingredient ID: NPC266940
Ingredient ID: NPC266712
Ingredient ID: NPC26574
Ingredient ID: NPC26431
Ingredient ID: NPC261405
Ingredient ID: NPC259315
Ingredient ID: NPC257421
Ingredient ID: NPC253165
Ingredient ID: NPC253090
Ingredient ID: NPC243860
Ingredient ID: NPC241081
Ingredient ID: NPC23765
Ingredient ID: NPC236709
Ingredient ID: NPC235292
Ingredient ID: NPC229622
Ingredient ID: NPC228433
Ingredient ID: NPC226169
Ingredient ID: NPC225665
Ingredient ID: NPC225507
Ingredient ID: NPC224651
Ingredient ID: NPC223461
Ingredient ID: NPC218410
Ingredient ID: NPC217763
Ingredient ID: NPC216333
Ingredient ID: NPC216267
Ingredient ID: NPC216081
Ingredient ID: NPC214535
Ingredient ID: NPC211579
Ingredient ID: NPC208486
Ingredient ID: NPC201856
Ingredient ID: NPC201399
Ingredient ID: NPC193238
Ingredient ID: NPC186422
Ingredient ID: NPC177676
Ingredient ID: NPC176874
Ingredient ID: NPC175308
Ingredient ID: NPC165122
Ingredient ID: NPC163021
Ingredient ID: NPC159789
Ingredient ID: NPC152195
Ingredient ID: NPC14208
Ingredient ID: NPC135046
Ingredient ID: NPC133922
Ingredient ID: NPC132840
Ingredient ID: NPC125575
Ingredient ID: NPC118736
Ingredient ID: NPC108896
Ingredient ID: NPC105224
Ingredient ID: NPC103267
Ingredient ID: NPC102759
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 10 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT02474082 | Study of Secukinumab Compared to Fumaderm® in Adults With Moderate to Severe Psoriasis. | psoriasis | Fumaric Acid (NPC224651) | NP level |
| NCT02126657 | The Efficacy and Safety of a Single 70% Glycolic Acid Peel With Vitamin C for the Treatment of Acne Scars | acne | Glycolic Acid (NPC165122) | NP level |
| NCT01985321 | Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for the Treatment of Cold Sores | Herpes Labialis | Glycolic Acid (NPC165122) | NP level |
| NCT04649203 | Cytoflavin in the Treatment of Patients With Diabetic Polyneuropathy | diabetic neuropathy | Succinic Acid (NPC236709) | NP level |
| NCT05362500 | Comparison of Chemical Peeling Agent With Transamine for Treatment of Melasma | freckles | Glycolic Acid (NPC165122) | NP level |
| NCT01321164 | Fumaric Acid Versus Fumaric Acid Plus Narrow Band Type B Ultraviolet (UVB) for Psoriasis | psoriasis | Fumaric Acid (NPC224651) | NP level |
| NCT02951533 | A Study to Compare the Efficacy of Guselkumab to Fumaric Acid Esters for the Treatment of Participants With Moderate to Severe Plaque Psoriasis | psoriasis | Fumaric Acid (NPC224651) | NP level |
| NCT02634801 | A Study of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque Psoriasis Naive to Systemic Treatment | psoriasis | Fumaric Acid (NPC224651) | NP level |
| NCT02812719 | Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel | freckles | Glycolic Acid (NPC165122) | NP level |
| NCT01352988 | Efficacy and Safety of Fumaric Acid Esters (Fumaderm®) in the Treatment of Patients With Cutaneous Lupus Erythematosus | cutaneous lupus erythematosus | Fumaric Acid (NPC224651) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
NCT02951533,NCT01321164,NCT02474082,NCT02634801
|
FrecklesDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED61.0 |
NCT02812719,NCT05362500
|
Cutaneous lupus erythematosusDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EB50-EB5Z |
NCT01352988
|
Diabetic polyneuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C03.0 |
NCT04649203
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT02126657
|
Herpes simplex labialisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00.01 |
NCT01985321
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
LMNA
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
LMNA
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
