CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Sloanea Zuliaensis

Example Image

PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO10443
Plant Latin Name: Sloanea Zuliaensis
Taxonomy Genus: Sloanea
Taxonomy Family: Elaeocarpaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

79 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

62 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

25 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC99587

Ingredient ID: NPC91495

Ingredient ID: NPC87475

Ingredient ID: NPC85571

Ingredient ID: NPC83838

Ingredient ID: NPC81419

Ingredient ID: NPC75078

Ingredient ID: NPC73617

Ingredient ID: NPC72675

Ingredient ID: NPC7183

Ingredient ID: NPC70400

Ingredient ID: NPC69918

Ingredient ID: NPC63100

Ingredient ID: NPC617

Ingredient ID: NPC57891

Ingredient ID: NPC55906

Ingredient ID: NPC51004

Ingredient ID: NPC48666

Ingredient ID: NPC47584

Ingredient ID: NPC38771

Ingredient ID: NPC3658

Ingredient ID: NPC35270

Ingredient ID: NPC35022

Ingredient ID: NPC311612

Ingredient ID: NPC309493

Ingredient ID: NPC30869

Ingredient ID: NPC307411

Ingredient ID: NPC30560

Ingredient ID: NPC30515

Ingredient ID: NPC301058

Ingredient ID: NPC300389

Ingredient ID: NPC286137

Ingredient ID: NPC282431

Ingredient ID: NPC274773

Ingredient ID: NPC272814

Ingredient ID: NPC271852

Ingredient ID: NPC267403

Ingredient ID: NPC257457

Ingredient ID: NPC25245

Ingredient ID: NPC24251

Ingredient ID: NPC239809

Ingredient ID: NPC236208

Ingredient ID: NPC231889

Ingredient ID: NPC226535

Ingredient ID: NPC221758

Ingredient ID: NPC221231

Ingredient ID: NPC208886

Ingredient ID: NPC20713

Ingredient ID: NPC202868

Ingredient ID: NPC202688

Ingredient ID: NPC202672

Ingredient ID: NPC194977

Ingredient ID: NPC192501

Ingredient ID: NPC191448

Ingredient ID: NPC186080

Ingredient ID: NPC184102

Ingredient ID: NPC179746

Ingredient ID: NPC176414

Ingredient ID: NPC173602

Ingredient ID: NPC171147

Ingredient ID: NPC17039

Ingredient ID: NPC162742

Ingredient ID: NPC161193

Ingredient ID: NPC157982

Ingredient ID: NPC15669

Ingredient ID: NPC151709

Ingredient ID: NPC141810

Ingredient ID: NPC137946

Ingredient ID: NPC135484

Ingredient ID: NPC128897

Ingredient ID: NPC12256

Ingredient ID: NPC12172

Ingredient ID: NPC117853

Ingredient ID: NPC115827

Ingredient ID: NPC112065

Ingredient ID: NPC111703

Ingredient ID: NPC107069

Ingredient ID: NPC106770

Ingredient ID: NPC101035

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Oxidoreductase	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Drug Transporter	SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	1

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT03645096	Development of Pregnenolone as a Treatment for Depression R61	major depressive disorder	Pregnenolone (NPC221758)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	SLCO1B1,SLCO1B3,ALOX15
Malignant neoplasms of oesophagus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B70	SLCO1B1,SLCO1B3,ALOX15
Adenocarcinoma of prostate Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82.0	SLCO1B1,SLCO1B3,ALOX15
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	SLCO1B3,ALOX15
Malignant neoplasm metastasis in lymph nodes of head, face or neck Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60.0	SLCO1B1,SLCO1B3
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	SLCO1B1,SLCO1B3
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	SLCO1B3,ALOX15
Other specified malignant neoplasms ofcolon Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90.Y	SLCO1B1,SLCO1B3
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	SLCO1B1,SLCO1B3
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	SLCO1B1,SLCO1B3
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	SLCO1B3,ALOX15
Single episode depressive disorder, severe, without psychotic symptoms Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A70.3	NCT03645096
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	ALOX15
Crohn disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD70	SLCO1B3
Inflammatory bowel diseases, unspecified Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD7Z	SLCO1B3
Idiopathic pulmonary fibrosis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB03.4	SLCO1B3
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	ALOX15
Other specified malignant neoplasms of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.Y	SLCO1B3
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	ALOX15
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	ALOX15
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	SLCO1B1

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Sloanea Zuliaensis

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

79 All known Ingredients in Total

62 Ingredients with Acceptable Bioavailablity

25 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Adenocarcinoma of stomach

Malignant neoplasms of oesophagus

Adenocarcinoma of prostate

Serous cystadenoma,borderline malignancy of ovary

Malignant neoplasm metastasis in lymph nodes of head, face or neck

Squamous cell carcinoma of bronchus or lung

Adenocarcinoma of pancreas

Other specified malignant neoplasms ofcolon

Urothelial carcinoma of bladder

Adenocarcinoma of bronchus or lung

Malignant neoplasms of corpus uteri, unspecified

Single episode depressive disorder, severe, without psychotic symptoms

Carcinosarcoma of uterus

Crohn disease

Inflammatory bowel diseases, unspecified

Idiopathic pulmonary fibrosis

Mesothelioma of pleura

Other specified malignant neoplasms of bronchus or lung

Cytomegaloviral disease

Malignant neoplasms of thymus

Germ cell tumour of testis

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities