Collective Molecular Activities of the Plant: Abies Pinsapo Var. Marocana
Unknown.
Morocco; Austria; Spain; Portugal
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
80 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
58 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
48 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98386
Ingredient ID: NPC86371
Ingredient ID: NPC84585
Ingredient ID: NPC80710
Ingredient ID: NPC78540
Ingredient ID: NPC71726
Ingredient ID: NPC50898
Ingredient ID: NPC46715
Ingredient ID: NPC43143
Ingredient ID: NPC42716
Ingredient ID: NPC41240
Ingredient ID: NPC35544
Ingredient ID: NPC35446
Ingredient ID: NPC34981
Ingredient ID: NPC32641
Ingredient ID: NPC31643
Ingredient ID: NPC30720
Ingredient ID: NPC305858
Ingredient ID: NPC297186
Ingredient ID: NPC29391
Ingredient ID: NPC291796
Ingredient ID: NPC284339
Ingredient ID: NPC279668
Ingredient ID: NPC279121
Ingredient ID: NPC277532
Ingredient ID: NPC27225
Ingredient ID: NPC270456
Ingredient ID: NPC263821
Ingredient ID: NPC262435
Ingredient ID: NPC258867
Ingredient ID: NPC258575
Ingredient ID: NPC258035
Ingredient ID: NPC253788
Ingredient ID: NPC253336
Ingredient ID: NPC243083
Ingredient ID: NPC240306
Ingredient ID: NPC234560
Ingredient ID: NPC234051
Ingredient ID: NPC226333
Ingredient ID: NPC222342
Ingredient ID: NPC221466
Ingredient ID: NPC219870
Ingredient ID: NPC213412
Ingredient ID: NPC209560
Ingredient ID: NPC209550
Ingredient ID: NPC20791
Ingredient ID: NPC207744
Ingredient ID: NPC202856
Ingredient ID: NPC196753
Ingredient ID: NPC19174
Ingredient ID: NPC185249
Ingredient ID: NPC181124
Ingredient ID: NPC180279
Ingredient ID: NPC176348
Ingredient ID: NPC175429
Ingredient ID: NPC17542
Ingredient ID: NPC17322
Ingredient ID: NPC17151
Ingredient ID: NPC169749
Ingredient ID: NPC160179
Ingredient ID: NPC156457
Ingredient ID: NPC156139
Ingredient ID: NPC150648
Ingredient ID: NPC147686
Ingredient ID: NPC143427
Ingredient ID: NPC142142
Ingredient ID: NPC139364
Ingredient ID: NPC138994
Ingredient ID: NPC138990
Ingredient ID: NPC130341
Ingredient ID: NPC128678
Ingredient ID: NPC125062
Ingredient ID: NPC121703
Ingredient ID: NPC12013
Ingredient ID: NPC116775
Ingredient ID: NPC107161
Ingredient ID: NPC106439
Ingredient ID: NPC106197
Ingredient ID: NPC102832
Ingredient ID: NPC100284
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 23 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00010686 | Dietary Phytoestrogens and Bone Metabolism | osteoporosis | Daidzein (NPC234560);Formononetin (NPC209560) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
| NCT01375101 | Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus | oral lichen planus | Quercetin (NPC20791) | NP level |
| NCT01438320 | Q-Trial in Patients With Hepatitis C | chronic hepatitis C virus infection | Quercetin (NPC20791) | NP level |
| NCT01708278 | Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) | chronic obstructive pulmonary disease | Quercetin (NPC20791) | NP level |
| NCT01720147 | Quercetin in Children With Fanconi Anemia; a Pilot Study | Fanconi anemia | Quercetin (NPC20791) | NP level |
| NCT01839344 | Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes. | type 2 diabetes mellitus | Quercetin (NPC20791) | NP level |
| NCT01912820 | Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery | prostate adenocarcinoma | Quercetin (NPC20791) | NP level |
| NCT02059785 | Phase ⅡStudy of Pinocembrin Injection to Treat Ischemic Stroke | Ischemic stroke | Pinocembrin (NPC243083) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR,MAOB
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,AKR1B1,KDR,DPP4
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
SRC,TOP2A,TP53,AXL,PIM1,AURKB,GSK3B,FLT3
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA7,AURKB,CYP2C9,ACHE,THPO,BLM,TOP2A,TTR,NPSR1,MMP12,CDK1,CA12,XDH,CBR1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA7,ALOX15,DPP4,CA2,RECQL,AURKB,CYP2C19,MAOB,CYP2C9,HIF1A,ACHE,AXL,ALOX5,BLM,TTR,NPSR1,LMNA,ABCG2,PIM1,POLB,CYP1B1,MET,HSD17B2,XDH,CISD1,CBR1,SNCA
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,ALOX15,TTR
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
ALOX15,AURKB,CYP19A1,BLM,TOP2A,NPSR1,MMP12,MET,CDK1,NOX4
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
