Collective Molecular Activities of the Plant: Bruguiera Cylindrica
Plant ID: NPO10036
Plant Latin Name: Bruguiera Cylindrica
Taxonomy Genus: Bruguiera
Taxonomy Family: Rhizophoraceae
Plant External Links:
NCBI TaxonomyDB:
106616
Plant-of-the-World-Online:
n.a.
Country/Region:
IndiaTraditional Medicine System:
Indian Folk; SiddhaIndia
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
50 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
10 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
17 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC92898
Ingredient ID: NPC8990
Ingredient ID: NPC86257
Ingredient ID: NPC7780
Ingredient ID: NPC76859
Ingredient ID: NPC74150
Ingredient ID: NPC73738
Ingredient ID: NPC70361
Ingredient ID: NPC59326
Ingredient ID: NPC53475
Ingredient ID: NPC42234
Ingredient ID: NPC3450
Ingredient ID: NPC308191
Ingredient ID: NPC307205
Ingredient ID: NPC282285
Ingredient ID: NPC281452
Ingredient ID: NPC276652
Ingredient ID: NPC27154
Ingredient ID: NPC270364
Ingredient ID: NPC264653
Ingredient ID: NPC26229
Ingredient ID: NPC262284
Ingredient ID: NPC261341
Ingredient ID: NPC25959
Ingredient ID: NPC259168
Ingredient ID: NPC252593
Ingredient ID: NPC24873
Ingredient ID: NPC24580
Ingredient ID: NPC243595
Ingredient ID: NPC242861
Ingredient ID: NPC235679
Ingredient ID: NPC23322
Ingredient ID: NPC230301
Ingredient ID: NPC215626
Ingredient ID: NPC212755
Ingredient ID: NPC206438
Ingredient ID: NPC206264
Ingredient ID: NPC202964
Ingredient ID: NPC159362
Ingredient ID: NPC156358
Ingredient ID: NPC151859
Ingredient ID: NPC145218
Ingredient ID: NPC143569
Ingredient ID: NPC137949
Ingredient ID: NPC122504
Ingredient ID: NPC11977
Ingredient ID: NPC118799
Ingredient ID: NPC118405
Ingredient ID: NPC11666
Ingredient ID: NPC105222
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Oxidoreductase | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Therapeutic Target | Protein Kinase | PRKCD | Protein kinase C delta | Q05655 | CHEMBL2996 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 148 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00004733 | Timing of Levodopa Treatment in Parkinson's Disease | Parkinson disease | Levodopa (NPC161593) | NP level |
| NCT00006077 | Effects of Monoamine Reuptake Inhibitor NS2330 in Parkinson's Disease | Parkinson disease | Levodopa (NPC161593) | NP level |
| NCT00006337 | KW-6002 to Treat Parkinson's Disease | Parkinson disease | Levodopa (NPC161593) | NP level |
| NCT00009048 | EMD 128130 for the Treatment of Parkinson's Disease | Parkinson disease | Levodopa (NPC161593) | NP level |
| NCT00013624 | Riluzole to Treat Parkinson's Disease | Parkinson disease | Levodopa (NPC161593) | NP level |
| NCT00040209 | JP-1730 to Treat Parkinson's Disease | Parkinson disease | Levodopa (NPC161593) | NP level |
| NCT00076674 | Levetiracetam Treatment of L-dopa Induced Dyskinesias | Parkinson disease | Levodopa (NPC161593) | NP level |
| NCT00086294 | ACP-103 to Treat Parkinson's Disease | Parkinson disease | Levodopa (NPC161593) | NP level |
| NCT00089622 | Lisuride Patch to Treat Parkinson's Disease | Parkinson disease | Levodopa (NPC161593) | NP level |
| NCT00099268 | Efficacy and Safety of Carbidopa/Levodopa/Entacapone in Patients With Parkinson's Disease Requiring Initiation of Levodopa Therapy | Parkinson disease | Levodopa (NPC161593) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT01387711
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA9,CA12,F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA9,F2,PRKCD
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Albinism or other specified genetically-determined hypomelanotic disordersDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EC23.2 |
NCT01176435
|
Amyotrophic lateral sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60.0 |
NCT03929068
|
Angelman syndromeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD90.0 |
NCT01281475,NCT00829439
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
AphasiaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MA80.0 |
NCT01429077
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
NCT02633007 |
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
