Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC10251 L3MBTL1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC103342 KDM4E 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC103342 CYP3A4 1 36200 IC50 PMID: 15270556
NPC107482 ALDH1A1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC114682 GAA 1 44668.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC114682 ALDH1A1 1 37650.5 Potency PubChem BioAssay data set
CHEMBL1201862
NPC114682 TDP1 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC114682 KDM4E 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC114682 RECQL 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC114682 BLM 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC114682 ALPPL2 1 18900 EC50 PubChem BioAssay data set
CHEMBL1201862
NPC126681 SLC6A9 1 31600 IC50 PMID: 24461352
NPC137958 CYP1A2 1 39810.72 AC50 PubChem BioAssay data set
CHEMBL1201862
NPC137958 SLC1A3 1 35000 Ki PMID: 18578477
NPC13991 MAPK1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC150809 CYP3A4 1 28700 IC50 PMID: 15679319
NPC157944 KDM4E 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC157944 ALDH1A1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC157944 TSHR 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC157944 TDP1 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC181465 XDH 1 14800 IC50 PMID: 9461655
NPC18188 SLC6A12 1 36000 IC50 PMID: 8057281
NPC18188 NPSR1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC18188 TSHR 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC18188 CYP1A2 1 31622.78 AC50 PubChem BioAssay data set
CHEMBL1201862
NPC18188 THRB 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC208793 LMNA 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC208793 CYP1A2 1 31622.78 AC50 PubChem BioAssay data set
CHEMBL1201862
NPC208793 CYP2C19 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC214067 ALDH1A1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC214067 TSHR 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC216630 PPARG 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC254847 EPHX2 1 36400 IC50 PMID: 26483136
NPC254847 APEX1 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC254847 TP53 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC254847 PTP4A3 2 Median: 31500
Range: 28000 to 35000
IC50 PMID: 22137788
PMID: 22137788
NPC254847 NPC1 1 20596.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC265885 RECQL 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC265885 GAA 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC265885 L3MBTL1 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC273330 CYP1A2 1 31622.78 AC50 PubChem BioAssay data set
CHEMBL1201862
NPC273330 CYP3A4 2 Median: 25118.9
Range: 25118.9 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC282923 BRCA1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC282923 CYP3A4 2 Median: 25118.9
Range: 25118.9 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC282923 USP2 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC282923 KDM4E 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC282923 TDP1 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC282923 ELANE 1 18000 IC50 PMID: 1578486
NPC282923 TSHR 2 Median: 15848.9
Range: 15848.9 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC287331 RECQL 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC287331 LMNA 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC287331 TSHR 2 Median: 15848.9
Range: 15848.9 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC292792 PPARA 1 46500 EC50 PMID: 22381047
NPC292792 PPARG 1 40000 EC50 PMID: 22381047
NPC292792 ALDH1A1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC294941 ALOX15 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC294941 KDM4E 3 Median: 35481.3
Range: 28183.8 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC294941 MAPK1 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC294941 HSD17B10 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC294941 ALDH1A1 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC294941 HPGD 2 Median: 21169.9
Range: 19952.6 to 22387.2
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC312929 KDM4E 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC312929 GLA 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC312929 ALDH1A1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC68889 ALOX15 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC71853 ALDH1A1 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC71853 ALOX15 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC8235 TDP1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC84772 FASN 1 49100 IC50 PMID: 16870425
NPC85813 CYP19A1 1 48000 IC50 PMID: 16643058
NPC85813 F3 1 41000 IC50 PMID: 9834151
NPC85813 HSD17B10 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC85813 TSHR 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC85813 CYP3A4 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC85813 ALDH1A1 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC10251 TSHR 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC103342 RECQL 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC114682 ALPI 1 11300 EC50 PubChem BioAssay data set
CHEMBL1201862
NPC12278 ALOX5 1 13000 IC50 PMID: 24568174
NPC254847 TDP1 2 Median: 15186.05
Range: 12589.3 to 17782.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC254847 CYP2D6 2 Median: 22106.05
Range: 12589.3 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC254847 THPO 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC254847 GMNN 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC254847 ALDH1A1 2 Median: 13357.35
Range: 12589.3 to 14125.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC254847 MAPK1 2 Median: 11904.75
Range: 11220.2 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC254847 POLB 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC282923 ALDH1A1 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC312929 HPGD 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC312929 ALOX15 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC71853 CYP3A4 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC71853 TSHR 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC71853 ALOX12 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC85813 FABP4 2 Median: 15650
Range: 13600 to 17700
IC50 PMID: 20471252
PMID: 25461324
NPC85813 PTGS1 1 13000 IC50 PMID: 16038536