Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC138299 ALDH1A1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC138299 PLCG1 1 29000 IC50 PMID: 10869194
NPC138299 PLA2G2A 1 23800 IC50 PMID: 16504502
NPC138299 HPGD 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC289774 TDP1 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC470090 HSD17B10 1 39810.7 Potency PMID: 20218657
NPC470090 TSHR 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PMID: 17315926
PMID: 17844994
NPC470090 KMT2A 1 31622.8 Potency PMID: 12088433
NPC470090 POLB 1 31622.8 Potency PMID: 15568791
NPC470090 PABPC1 1 30850 IC50 DrugMatrix in vitro pharmacology data
CHEMBL1909046
NPC470090 CYP2C9 2 Median: 28370.85
Range: 25118.9 to 31622.8
Potency PMID: 17279798
DrugMatrix in vitro pharmacology data
CHEMBL1909046
NPC470090 MTOR 1 20749.1 Potency PMID: 23127886
NPC470090 HIF1A 2 Median: 15848.9
Range: 15848.9 to 15848.9
Potency PMID: 10425124
PMID: 20143778
NPC470090 APEX1 1 15848.9 Potency PMID: 19916529
NPC471603 ALDH1A1 3 Median: 39810.7
Range: 35481.3 to 39810.7
Potency PMID: 19114678
DOI: 10.6019/CHEMBL1201861
Open TG-GATES
CHEMBL3885861
NPC471603 HSD17B10 1 31622.8 Potency PMID: 19191549
NPC471603 THPO 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PMID: 13678412
PMID: 16038541
NPC471603 PMP22 1 26854.5 Potency PMID: 8229009
NPC471603 GMNN 1 22387.2 Potency PMID: 21824777
NPC471603 CYP1A2 1 15848.93 AC50 PMID: 25700232
NPC471603 HPGD 2 Median: 20483.9
Range: 15848.9 to 25118.9
Potency PMID: 8691203
PMID: 22934671
NPC471603 ALOX15 1 15848.9 Potency Open TG-GATES
CHEMBL3885861
NPC471603 KDM4E 2 Median: 22874.1
Range: 14125.4 to 31622.8
Potency PMID: 19689125
PMID: 22409377
NPC470090 KDM4E 1 12589.3 Potency PMID: 23210623
NPC470090 NPC1 1 10322.5 Potency PMID: 16038541
NPC471603 NFKB1 2 Median: 11220.2
Range: 11220.2 to 11220.2
Potency PMID: 22194678
Open TG-GATES
CHEMBL3885861