Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC116709 CYP1A2 1 31622.78 AC50 PubChem BioAssay data set
CHEMBL1201862
NPC126681 SLC6A9 1 31600 IC50 PMID: 24461352
NPC13991 MAPK1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC157340 ALDH1A1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC18188 SLC6A12 1 36000 IC50 PMID: 8057281
NPC18188 NPSR1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC18188 TSHR 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC18188 CYP1A2 1 31622.78 AC50 PubChem BioAssay data set
CHEMBL1201862
NPC18188 THRB 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC190184 LMNA 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC190184 TSHR 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC197087 ALOX15 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC197087 KMT2A 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC208793 LMNA 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC208793 CYP1A2 1 31622.78 AC50 PubChem BioAssay data set
CHEMBL1201862
NPC208793 CYP2C19 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC208936 ALDH1A1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC208936 TSHR 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC209970 ALOX15 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC209970 PPARG 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC209970 TDP1 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC209970 HSD17B10 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC216630 PPARG 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC217226 ALDH1A1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC224651 EGLN1 2 Median: 119500
Range: 19000 to 220000
IC50 PMID: 18942826
PMID: 23234607
NPC226453 APEX1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC226453 CYP1A2 1 31622.78 AC50 PubChem BioAssay data set
CHEMBL1201862
NPC237435 CDK1 1 14360 IC50 PMID: 18639462
NPC261831 BLM 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC261831 CYP19A1 1 32700 IC50 PMID: 16643058
NPC261831 TOP1 1 31000 IC50 PMID: 12444712
NPC261831 MAPT 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC261831 FABP4 1 26100 IC50 PMID: 20471252
NPC261831 KMT2A 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC261831 ATM 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC261831 HSD17B10 2 Median: 17900.75
Range: 15848.9 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC301696 ALDH1A1 1 44668.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC43246 SLC28A2 1 32000 IC50 PMID: 23388705
NPC7491 CYP2C9 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC85813 CYP19A1 1 48000 IC50 PMID: 16643058
NPC85813 F3 1 41000 IC50 PMID: 9834151
NPC85813 HSD17B10 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC85813 TSHR 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC85813 CYP3A4 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC85813 ALDH1A1 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC18335 XDH 1 10890 IC50 PMID: 17379526
NPC190184 CYP3A4 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC237435 PREP 2 Median: 12150
Range: 12000 to 12300
IC50 PMID: 18650094
PMID: 20058865
NPC261831 KCNH2 1 10410 EC50 PubChem BioAssay data set
CHEMBL1201862
NPC293378 ALDH1A1 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC51758 ALOX15 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC7491 CYP2C19 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC85813 FABP4 2 Median: 15650
Range: 13600 to 17700
IC50 PMID: 20471252
PMID: 25461324
NPC85813 PTGS1 1 13000 IC50 PMID: 16038536