Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC110899 CA5B 1 35400 Ki PMID: 20185318
NPC116775 BCHE 1 43100 Ki PMID: 19879672
NPC116775 ALDH1A1 2 Median: 35716.75
Range: 31622.8 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC116775 HPGD 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC116775 CDK6 2 Median: 22000
Range: 22000 to 22000
IC50 PMID: 15689157
DOI: 10.1007/s00044-009-9233-5
NPC116775 GLO1 1 20600 IC50 PMID: 18258440
NPC116775 KDM4E 2 Median: 27829.8
Range: 15848.9 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC116775 HSD17B10 2 Median: 15848.9
Range: 15848.9 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC116775 BACE1 1 14700 IC50 DOI: 10.1007/s00044-012-0353-y
NPC138113 TSHR 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC156654 L3MBTL1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC156654 KDM4E 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC156654 POLB 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC201844 PPARA 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC201844 PPARD 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC201844 PPARG 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC204932 CA14 2 Median: 48900
Range: 48900 to 48900
Ki PMID: 18579385
PMID: 20185318
NPC204932 BLM 2 Median: 44668.4
Range: 44668.4 to 44668.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC204932 POLB 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 APEX1 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 EGFR 1 26043 IC50 DrugMatrix in vitro pharmacology data
CHEMBL1909046
NPC204932 MMP9 1 23367 IC50 DrugMatrix in vitro pharmacology data
CHEMBL1909046
NPC204932 TDP1 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 L3MBTL1 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 FYN 1 17431 IC50 DrugMatrix in vitro pharmacology data
CHEMBL1909046
NPC204932 RECQL 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 ALOX15 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 KDM4E 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 PMP22 1 47754.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 THRB 1 44668.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 GALK1 1 42128.5 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 CDK2 1 40000 IC50 PMID: 17178224
NPC20791 CD38 1 37900 IC50 PMID: 21641214
NPC20791 SORD 2 Median: 106300
Range: 35600 to 177000
IC50 PMID: 8893834
PMID: 12672241
NPC20791 SMN1;SMN2 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 EPHX2 1 33540 IC50 PMID: 24679441
NPC20791 DPP4 2 Median: 81365
Range: 32730 to 130000
IC50 PMID: 18650094
DOI: 10.1039/C0MD00245C
NPC20791 MAPK1 2 Median: 35716.75
Range: 31622.8 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 ADORA3 1 30000 Ki PMID: 8576921
NPC20791 PTGS2 1 28600 IC50 PMID: 17378609
NPC20791 BLM 3 Median: 28183.8
Range: 28183.8 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 TDP1 2 Median: 26651.35
Range: 25118.9 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 ALDH1A1 6 Median: 37646
Range: 25118.9 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 CDK6 2 Median: 25000
Range: 25000 to 25000
IC50 PMID: 15689157
DOI: 10.1007/s00044-009-9233-5
NPC20791 PTPN1 2 Median: 23300
Range: 23300 to 23300
IC50 PMID: 12419367
PMID: 19297174
NPC20791 KMT2A 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 AMY1A;AMY1B;AMY1C 1 21400 IC50 PMID: 18507367
NPC20791 SYK 1 20000 IC50 PMID: 22257213
NPC20791 HPGD 2 Median: 21169.9
Range: 19952.6 to 22387.2
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 APEX1 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 CYP2D6 1 18800 IC50 PMID: 22328583
NPC20791 USP2 2 Median: 25057.75
Range: 18492.7 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 GPR35 1 15400 IC50 PMID: 24900447
NPC20791 APP 1 15300 IC50 PMID: 26719209
NPC216630 PPARG 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC217226 ALDH1A1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 HSD17B10 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 PTGS1 2 Median: 58350
Range: 36700 to 80000
IC50 PMID: 11858749
PMID: 16038536
NPC219876 SMN1;SMN2 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 NPSR1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 BLM 2 Median: 28183.8
Range: 28183.8 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC219876 ALDH1A1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 RECQL 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 MAPT 2 Median: 19952.6
Range: 19952.6 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC219876 APEX1 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC225710 SELL 1 27600 IC50 PMID: 17302397
NPC225710 GAPDH 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC225710 MAPK1 2 Median: 23753.05
Range: 22387.2 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC225710 SELP 1 19100 IC50 PMID: 17302397
NPC225710 SMN1;SMN2 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC246162 APP 1 33000 IC50 PMID: 26719209
NPC246162 BACE1 2 Median: 32500
Range: 30000 to 35000
IC50 PMID: 14592472
PMID: 14592472
NPC246162 RECQL 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC246162 KDM4E 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC246162 MAPT 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC246162 KIT 2 Median: 18800
Range: 15700 to 21900
IC50 PMID: 26807861
PMID: 26807861
NPC255042 CYP3A4 2 Median: 15848.9
Range: 15848.9 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC257124 AR 2 Median: 19027.305
Range: 19000 to 19054.61
IC50 PMID: 20226658
PMID: 20226658
NPC260491 MAPT 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC260491 RECQL 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 GALK1 1 47269 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 THRB 1 44668.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 TSHR 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 CYP2C9 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 CYP2D6 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 GAA 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 DAPK1 1 21000 IC50 PMID: 26322379
NPC279121 CDK2 1 20000 IC50 PMID: 17178224
NPC279121 TDP1 2 Median: 29881.65
Range: 19952.6 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC279121 ABCB1 1 19600 IC50 PMID: 15240100
NPC279121 GPR35 1 18600 IC50 PMID: 24900447
NPC279121 AMY1A;AMY1B;AMY1C 1 18400 IC50 PMID: 18507367
NPC279121 MMP3 1 16200 IC50 PMID: 22658537
NPC279121 CYP2C19 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 BLM 2 Median: 17900.75
Range: 15848.9 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC280254 LMNA 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC286342 GAA 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC286342 RECQL 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC286342 MAPT 2 Median: 14987.15
Range: 14125.4 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC287331 RECQL 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC287331 LMNA 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC287331 TSHR 2 Median: 15848.9
Range: 15848.9 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC288943 HSD17B10 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC301585 PPARD 1 24000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC301585 PPARG 1 21000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC36835 SMN1;SMN2 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC36835 RECQL 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC36835 MMP13 1 34600 IC50 PMID: 22658537
NPC36835 ADORA3 1 34100 Ki PMID: 8576921
NPC36835 MMP3 1 33910 IC50 PMID: 22658537
NPC36835 MMP9 1 32020 IC50 PMID: 22658537
NPC36835 GMNN 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC36835 CYP3A4 2 Median: 25118.9
Range: 25118.9 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC36835 MMP2 1 22620 IC50 PMID: 22658537
NPC36835 MAPT 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC61477 HPGD 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC61477 MAPK1 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC61477 RECQL 2 Median: 77689.6
Range: 14125.4 to 141253.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC66083 LMNA 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC66083 KDM4E 2 Median: 33552.05
Range: 31622.8 to 35481.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC66083 HSD17B10 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC66083 CYP2C9 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC66083 ALDH1A1 2 Median: 28370.85
Range: 25118.9 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC66083 HPGD 2 Median: 25787.7
Range: 19952.6 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC68889 ALOX15 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC85813 CYP19A1 1 48000 IC50 PMID: 16643058
NPC85813 F3 1 41000 IC50 PMID: 9834151
NPC85813 HSD17B10 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC85813 TSHR 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC85813 CYP3A4 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC85813 ALDH1A1 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC87125 CYP3A4 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC87125 TDP1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC87125 KDM4E 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC87125 HSD17B10 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC110899 CA4 1 10600 Ki PMID: 20185318
NPC116775 MAPT 2 Median: 14219.1
Range: 12589.3 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC201844 ALDH1A1 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 ALDH1A1 2 Median: 15954.1
Range: 14125.4 to 17782.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC204932 CA3 2 Median: 13000
Range: 13000 to 13000
Ki PMID: 18579385
PMID: 20185318
NPC204932 SMN1;SMN2 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 HIF1A 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC204932 LMNA 2 Median: 23350.75
Range: 11220.2 to 35481.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC204932 HPGD 2 Median: 14501.5
Range: 11220.2 to 17782.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC204932 GMNN 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 CA4 3 Median: 10900
Range: 10900 to 10900
Ki PMID: 18579385
PMID: 20185318
PMID: 22245047
NPC20791 LMNA 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 PIK3CG 1 13790 IC50 PMID: 25050878
NPC20791 PREP 1 13000 IC50 PMID: 18650094
NPC20791 LCK 2 Median: 13000
Range: 13000 to 13000
IC50 PMID: 1995903
PMID: 16441060
NPC20791 CALM1;CALM2;CALM3 1 12970 IC50 PMID: 21129983
NPC20791 PLAU 1 12100 IC50 PMID: 24610996
NPC20791 CA5B 1 11900 Ki PMID: 20185318
NPC20791 CYP2C19 1 10500 IC50 PMID: 22328583
NPC20791 MMP12 1 10230 IC50 PMID: 22658537
NPC20791 HIF1AN 1 10200 IC50 PMID: 19822432
NPC20791 CYP2C9 1 10200 IC50 PMID: 22328583
NPC219876 KDM4E 2 Median: 19622.15
Range: 14125.4 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC219876 POLB 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC225710 FUT4 1 14000 IC50 DOI: 10.1039/C4MD00086B
NPC257124 ALDH1A1 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC257124 PTGS1 1 11000 IC50 PMID: 16038536
NPC260491 KDM4E 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 MAPT 3 Median: 12589.3
Range: 12589.3 to 17782.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC279121 SYK 1 12000 IC50 PMID: 22257213
NPC279121 HPGD 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 MMP13 1 10050 IC50 PMID: 22658537
NPC280254 ALOX15 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC286342 KDM4E 2 Median: 17039
Range: 14125.4 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC286342 BLM 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC29883 CA2 2 Median: 10600
Range: 10600 to 10600
Ki PMID: 18501600
PMID: 18579385
NPC61477 MAPT 2 Median: 14125.4
Range: 14125.4 to 14125.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC61477 ALOX15 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC61477 CA14 1 11550 Ki PMID: 20674354
NPC61477 KDM4E 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC61477 CA13 1 10510 Ki PMID: 20674354
NPC61506 RECQL 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC85813 FABP4 2 Median: 15650
Range: 13600 to 17700
IC50 PMID: 20471252
PMID: 25461324
NPC85813 PTGS1 1 13000 IC50 PMID: 16038536
NPC87125 LMNA 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862