Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC1075 CYP2C9 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC110899 CA5B 1 35400 Ki PMID: 20185318
NPC115207 PTPN1 1 18690 IC50 PMID: 24224843
NPC116775 BCHE 1 43100 Ki PMID: 19879672
NPC116775 ALDH1A1 2 Median: 35716.75
Range: 31622.8 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC116775 HPGD 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC116775 CDK6 2 Median: 22000
Range: 22000 to 22000
IC50 PMID: 15689157
DOI: 10.1007/s00044-009-9233-5
NPC116775 GLO1 1 20600 IC50 PMID: 18258440
NPC116775 KDM4E 2 Median: 27829.8
Range: 15848.9 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC116775 HSD17B10 2 Median: 15848.9
Range: 15848.9 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC116775 BACE1 1 14700 IC50 DOI: 10.1007/s00044-012-0353-y
NPC126029 TSHR 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC126681 SLC6A9 1 31600 IC50 PMID: 24461352
NPC141765 PPARD 1 18110 EC50 PMID: 27450788
NPC141765 PTPN1 1 15010 IC50 PMID: 24224843
NPC156461 GAPDH 7 Median: 35000000
Range: 35000 to 100000000
IC50 PMID: 7562915
PMID: 7562915
PMID: 7562915
PMID: 7932587
PMID: 7932587
PMID: 7932587
PMID: 9822549
NPC156461 ADORA2B 3 Median: 24000
Range: 24000 to 24000
EC50 PMID: 20541935
PMID: 21388809
PMID: 24164628
NPC156461 SLC29A1 1 17000 IC50 PMID: 23388705
NPC156654 L3MBTL1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC156654 KDM4E 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC156654 POLB 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC1591 SMN1;SMN2 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC1591 CHRNA3 4 Median: 81976.31
Range: 19000 to 144543.98
EC50 PMID: 18989912
PMID: 18989912
PMID: 19027295
PMID: 19027295
NPC161557 PPARD 1 49500 EC50 PMID: 22381047
NPC169749 DPP4 1 37150 IC50 DOI: 10.1039/C0MD00245C
NPC169749 ALPL 1 33200 IC50 PubChem BioAssay data set
CHEMBL1201862
NPC169749 ALPPL2 1 32300 EC50 PubChem BioAssay data set
CHEMBL1201862
NPC169749 KMT2A 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC169749 AMY1A;AMY1B;AMY1C 1 30200 IC50 PMID: 18507367
NPC169749 AKR1B1 1 29000 IC50 PMID: 18165015
NPC169749 CD38 1 24800 IC50 PMID: 21641214
NPC169749 DAPK1 1 23000 IC50 PMID: 26322379
NPC169749 ABCC2 1 22000 IC50 PMID: 19725578
NPC169749 ABCC1 1 20000 IC50 PMID: 19725578
NPC169749 CYP2D6 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC169749 APOBEC3A 1 17500 IC50 PubChem BioAssay data set
CHEMBL1201862
NPC169749 MTOR 2 Median: 19881.25
Range: 16481.6 to 23280.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC169749 BLM 3 Median: 14125.4
Range: 14125.4 to 14125.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC169749 ALOX12 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC176740 MAPT 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC176740 EPHX2 1 24300 IC50 PMID: 24679441
NPC176740 KDM4E 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 PMP22 1 47754.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 THRB 1 44668.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 GALK1 1 42128.5 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 CDK2 1 40000 IC50 PMID: 17178224
NPC20791 CD38 1 37900 IC50 PMID: 21641214
NPC20791 SORD 2 Median: 106300
Range: 35600 to 177000
IC50 PMID: 8893834
PMID: 12672241
NPC20791 SMN1;SMN2 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 EPHX2 1 33540 IC50 PMID: 24679441
NPC20791 DPP4 2 Median: 81365
Range: 32730 to 130000
IC50 PMID: 18650094
DOI: 10.1039/C0MD00245C
NPC20791 MAPK1 2 Median: 35716.75
Range: 31622.8 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 ADORA3 1 30000 Ki PMID: 8576921
NPC20791 PTGS2 1 28600 IC50 PMID: 17378609
NPC20791 BLM 3 Median: 28183.8
Range: 28183.8 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 TDP1 2 Median: 26651.35
Range: 25118.9 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 ALDH1A1 6 Median: 37646
Range: 25118.9 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 CDK6 2 Median: 25000
Range: 25000 to 25000
IC50 PMID: 15689157
DOI: 10.1007/s00044-009-9233-5
NPC20791 PTPN1 2 Median: 23300
Range: 23300 to 23300
IC50 PMID: 12419367
PMID: 19297174
NPC20791 KMT2A 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 AMY1A;AMY1B;AMY1C 1 21400 IC50 PMID: 18507367
NPC20791 SYK 1 20000 IC50 PMID: 22257213
NPC20791 HPGD 2 Median: 21169.9
Range: 19952.6 to 22387.2
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 APEX1 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 CYP2D6 1 18800 IC50 PMID: 22328583
NPC20791 USP2 2 Median: 25057.75
Range: 18492.7 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 GPR35 1 15400 IC50 PMID: 24900447
NPC20791 APP 1 15300 IC50 PMID: 26719209
NPC219876 HSD17B10 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 PTGS1 2 Median: 58350
Range: 36700 to 80000
IC50 PMID: 11858749
PMID: 16038536
NPC219876 SMN1;SMN2 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 NPSR1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 BLM 2 Median: 28183.8
Range: 28183.8 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC219876 ALDH1A1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 RECQL 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 MAPT 2 Median: 19952.6
Range: 19952.6 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC219876 APEX1 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC225710 SELL 1 27600 IC50 PMID: 17302397
NPC225710 GAPDH 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC225710 MAPK1 2 Median: 23753.05
Range: 22387.2 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC225710 SELP 1 19100 IC50 PMID: 17302397
NPC225710 SMN1;SMN2 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC230301 DPP4 1 28840 IC50 DOI: 10.1039/C0MD00245C
NPC230301 POLB 1 26300 IC50 PMID: 14640519
NPC250436 CREBBP 1 50000 IC50 PMID: 26701186
NPC250436 EP300 1 30000 IC50 PMID: 26701186
NPC250436 MMP7 1 21500 IC50 PMID: 19524436
NPC250436 PIN1 1 20000 IC50 PMID: 23796453
NPC261619 BACE1 2 Median: 25500
Range: 23000 to 28000
IC50 PMID: 14592472
PMID: 14592472
NPC279121 GALK1 1 47269 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 THRB 1 44668.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 TSHR 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 CYP2C9 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 CYP2D6 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 GAA 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 DAPK1 1 21000 IC50 PMID: 26322379
NPC279121 CDK2 1 20000 IC50 PMID: 17178224
NPC279121 TDP1 2 Median: 29881.65
Range: 19952.6 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC279121 ABCB1 1 19600 IC50 PMID: 15240100
NPC279121 GPR35 1 18600 IC50 PMID: 24900447
NPC279121 AMY1A;AMY1B;AMY1C 1 18400 IC50 PMID: 18507367
NPC279121 MMP3 1 16200 IC50 PMID: 22658537
NPC279121 CYP2C19 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 BLM 2 Median: 17900.75
Range: 15848.9 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC294902 HPGD 3 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC294902 ALDH1A1 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC294902 APEX1 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC294902 APP 1 32800 IC50 PMID: 22921742
NPC294902 AKR1B1 1 32000 IC50 PMID: 22236472
NPC294902 CYP3A4 2 Median: 25118.9
Range: 25118.9 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC294902 POLB 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC300845 HSP90AB1 1 34000 IC50 PMID: 24745965
NPC302950 ATM 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC302950 CYP1A2 1 34647 IC50 PMID: 20696580
NPC302950 GSK3B 1 26900 IC50 DOI: 10.1007/s00044-012-0353-y
NPC302950 TP53 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC32441 GSK3B 1 45700 IC50 DOI: 10.1007/s00044-012-0353-y
NPC32441 AKR1B1 1 28870 IC50 PMID: 22261024
NPC32441 CYP1A2 1 26339 IC50 PMID: 20696580
NPC32441 CALM1;CALM2;CALM3 1 22010 IC50 PMID: 21129983
NPC32441 CBR1 1 21480 IC50 PMID: 19097799
NPC32441 HSD17B10 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC32441 CYP1A1 1 15167 IC50 PMID: 20696580
NPC32441 HSD17B2 1 14400 IC50 PMID: 18533708
NPC50898 APEX1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC50898 THRB 2 Median: 44964.7
Range: 39810.7 to 50118.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 BACE1 2 Median: 38500
Range: 38500 to 38500
IC50 PMID: 22243648
DOI: 10.1007/s00044-012-0353-y
NPC50898 BCHE 1 37400 Ki PMID: 19879672
NPC50898 HBB 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC50898 HSD17B10 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 DAPK1 1 31000 IC50 PMID: 26322379
NPC50898 NPSR1 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC50898 HPGD 3 Median: 28183.8
Range: 22387.2 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 NFKB1 2 Median: 19952.6
Range: 19952.6 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 MAPK1 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC61477 HPGD 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC61477 MAPK1 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC61477 RECQL 2 Median: 77689.6
Range: 14125.4 to 141253.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC70744 KDM4E 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC76336 GLA 2 Median: 40074.85
Range: 35481.3 to 44668.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC76336 GAA 2 Median: 40074.85
Range: 35481.3 to 44668.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC76336 RECQL 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC76336 CA13 1 17800 Ki PMID: 22892213
NPC79943 ALOX12 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC81010 ESR1 1 16120 EC50 PMID: 23608764
NPC88803 MAPK1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC88803 BLM 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC88803 USP2 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC88803 ALDH1A1 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC88803 CYP3A4 2 Median: 19952.6
Range: 19952.6 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC88803 HPGD 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC1075 KDM4E 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC110899 CA4 1 10600 Ki PMID: 20185318
NPC115207 ALOX5 1 13800 IC50 PMID: 17378609
NPC116775 MAPT 2 Median: 14219.1
Range: 12589.3 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC126029 CYP3A4 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC126029 KDM4E 2 Median: 16803.7
Range: 11220.2 to 22387.2
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC156461 MAPK1 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC169749 HSP90AB1 1 13500 IC50 PMID: 24548207
NPC20791 LMNA 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 PIK3CG 1 13790 IC50 PMID: 25050878
NPC20791 PREP 1 13000 IC50 PMID: 18650094
NPC20791 LCK 2 Median: 13000
Range: 13000 to 13000
IC50 PMID: 1995903
PMID: 16441060
NPC20791 CALM1;CALM2;CALM3 1 12970 IC50 PMID: 21129983
NPC20791 PLAU 1 12100 IC50 PMID: 24610996
NPC20791 CA5B 1 11900 Ki PMID: 20185318
NPC20791 CYP2C19 1 10500 IC50 PMID: 22328583
NPC20791 MMP12 1 10230 IC50 PMID: 22658537
NPC20791 HIF1AN 1 10200 IC50 PMID: 19822432
NPC20791 CYP2C9 1 10200 IC50 PMID: 22328583
NPC219876 KDM4E 2 Median: 19622.15
Range: 14125.4 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC219876 POLB 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC225710 FUT4 1 14000 IC50 DOI: 10.1039/C4MD00086B
NPC250436 ELANE 1 12800 IC50 PMID: 20004577
NPC279121 MAPT 3 Median: 12589.3
Range: 12589.3 to 17782.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC279121 SYK 1 12000 IC50 PMID: 22257213
NPC279121 HPGD 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 MMP13 1 10050 IC50 PMID: 22658537
NPC294902 THRB 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC294902 CA4 1 10100 Ki PMID: 20185318
NPC29883 CA2 2 Median: 10600
Range: 10600 to 10600
Ki PMID: 18501600
PMID: 18579385
NPC302950 ALDH1A1 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC302950 HSD17B10 2 Median: 14219.1
Range: 12589.3 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC32441 ESR2 1 13473 IC50 PMID: 17149865
NPC32441 CYP2C9 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC50898 SMN1;SMN2 5 Median: 22387.2
Range: 14125.4 to 35481.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 MAOB 1 12800 IC50 PMID: 20045650
NPC50898 CYP2D6 2 Median: 26200
Range: 12589.3 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 GMNN 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC50898 LMNA 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 AKR1B1 1 11900 IC50 PMID: 26529431
NPC50898 KDM4E 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC61477 MAPT 2 Median: 14125.4
Range: 14125.4 to 14125.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC61477 ALOX15 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC61477 CA14 1 11550 Ki PMID: 20674354
NPC61477 KDM4E 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC61477 CA13 1 10510 Ki PMID: 20674354
NPC70744 CA3 1 11100 Ki PMID: 20185318
NPC70744 CA4 1 10800 Ki PMID: 20185318
NPC70744 CA5B 1 10500 Ki PMID: 20185318
NPC76336 HIF1A 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC76336 CA1 1 10560 Ki PMID: 22892213
NPC81010 HCAR2 1 14000 Ki PMID: 21167710
NPC99572 CYP3A4 1 13700 IC50 PMID: 15679319