Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC19174 BACE1 1 33000 IC50 DOI: 10.1007/s00044-012-0353-y
NPC19174 NPSR1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC19174 KMT2A 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC19174 HPGD 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC19174 MTOR 1 26121.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC19174 APP 1 19700 IC50 PMID: 23786711
NPC19174 GMNN 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC19174 PMP22 1 15101.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC234560 PMP22 1 47754.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC234560 AKR1B10 1 32200 IC50 PMID: 26529431
NPC234560 HSD17B10 3 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC234560 ALDH1A1 7 Median: 35481.3
Range: 25118.9 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC234560 PKM 2 Median: 25118.9
Range: 25118.9 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC234560 KDM4E 4 Median: 29903.3
Range: 19952.6 to 35481.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC234560 CYP1A2 1 15848.93 AC50 PubChem BioAssay data set
CHEMBL1201862
NPC234560 CYP3A4 4 Median: 20483.9
Range: 15848.9 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC234560 CYP2D6 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC234560 HPGD 4 Median: 28370.85
Range: 14125.4 to 35481.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC266689 LMNA 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC32441 GSK3B 1 45700 IC50 DOI: 10.1007/s00044-012-0353-y
NPC32441 AKR1B1 1 28870 IC50 PMID: 22261024
NPC32441 CYP1A2 1 26339 IC50 PMID: 20696580
NPC32441 CALM1;CALM2;CALM3 1 22010 IC50 PMID: 21129983
NPC32441 CBR1 1 21480 IC50 PMID: 19097799
NPC32441 HSD17B10 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC32441 CYP1A1 1 15167 IC50 PMID: 20696580
NPC32441 HSD17B2 1 14400 IC50 PMID: 18533708
NPC39426 SYK 1 39000 IC50 PMID: 19254842
NPC39426 ALDH1A1 2 Median: 37646
Range: 35481.3 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC39426 NR1H3 1 31000 IC50 PMID: 18343126
NPC39426 DNMT1 1 30000 IC50 PMID: 25406944
NPC39426 ODC1 1 26000 IC50 PMID: 10075742
NPC39426 PKM 2 Median: 25118.9
Range: 25118.9 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC39426 SMN1;SMN2 3 Median: 25118.9
Range: 22387.2 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC39426 NR1H2 1 22000 IC50 PMID: 18343126
NPC39426 AKR1B1 1 20000 IC50 PMID: 22261024
NPC39426 ALOX15 2 Median: 25787.7
Range: 19952.6 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC39426 ADORA1 1 19904 IC50 DrugMatrix in vitro pharmacology data
CHEMBL1909046
NPC39426 ADORA2A 1 17442 IC50 DrugMatrix in vitro pharmacology data
CHEMBL1909046
NPC39426 PMP22 1 16944.1 Potency PubChem BioAssay data set
CHEMBL1201862
NPC39426 SLC6A3 1 16918 IC50 DrugMatrix in vitro pharmacology data
CHEMBL1909046
NPC39426 HSD17B2 1 16500 IC50 PMID: 18533708
NPC39426 LMNA 2 Median: 15848.9
Range: 15848.9 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC39426 HTR2C 1 14910 IC50 DrugMatrix in vitro pharmacology data
CHEMBL1909046
NPC72158 PTPN1 1 27300 IC50 PMID: 24047800
NPC19174 CHRNA7 1 11600 EC50 PMID: 25232969
NPC234560 SMN1;SMN2 4 Median: 22016.35
Range: 12589.3 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC32441 ESR2 1 13473 IC50 PMID: 17149865
NPC32441 CYP2C9 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC39426 HPGD 4 Median: 19952.6
Range: 11220.2 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC39426 HTR2A 1 10469 IC50 DrugMatrix in vitro pharmacology data
CHEMBL1909046