Plant Name: Pericopsis angolensis
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 1.101E-08 | 3.629E-05 | CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 1.571E-08 | 3.933E-05 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 1.531E-07 | 1.389E-04 | CYP1A1, CYP1A2, CYP1B1 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.823E-07 | 1.527E-04 | CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 8.607E-07 | 5.355E-04 | ALOX12, CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0050896; response to stimulus | GO:0055093; response to hyperoxia | 1.683E-06 | 8.945E-04 | CYP1A1, POLB, TP53 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 1.683E-06 | 8.945E-04 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0065007; biological regulation | GO:0065008; regulation of biological quality | 1.725E-06 | 8.945E-04 | ALOX12, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, MAPT, NPC1, POLB, PPARA, PPARD, SYK, TLR2, TP53 |
| BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 2.238E-06 | 1.083E-03 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 5.646E-06 | 2.157E-03 | ALOX12, SYK, TLR2 |
| BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 7.420E-06 | 2.650E-03 | CYP1A1, CYP1A2 |
| BP | GO:0050896; response to stimulus | GO:0042493; response to drug | 1.181E-05 | 3.840E-03 | CYP1A1, CYP1B1, FABP3, NPC1, POLB, TLR2, TP53 |
| BP | GO:0008152; metabolic process | GO:0016125; sterol metabolic process | 1.227E-05 | 3.872E-03 | CYP19A1, CYP1B1, NPC1, PPARD |
| MF | GO:0005488; binding | GO:0020037; heme binding | 1.227E-05 | 3.872E-03 | CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0009987; cellular process | GO:0071216; cellular response to biotic stimulus | 2.292E-05 | 6.654E-03 | PPARD, SYK, TLR2, TP53 |
| BP | GO:0050896; response to stimulus | GO:0010038; response to metal ion | 2.489E-05 | 6.948E-03 | CYP1A1, CYP1A2, FABP4, NPC1, TP53 |
| MF | GO:0005488; binding | GO:0097371; MDM2/MDM4 family protein binding | 2.591E-05 | 7.008E-03 | PPARA, TP53 |
| MF | GO:0005488; binding | GO:0019902; phosphatase binding | 3.252E-05 | 8.636E-03 | MAPT, PPARA, SYK, TP53 |
| BP | GO:0008152; metabolic process | GO:0050665; hydrogen peroxide biosynthetic process | 3.453E-05 | 9.059E-03 | CYP1A1, CYP1A2 |
| BP | GO:0008152; metabolic process | GO:2000377; regulation of reactive oxygen species metabolic process | 3.658E-05 | 9.481E-03 | CYP1B1, MAPT, SYK, TP53 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 9.644E-11 | 8.294E-09 | FABP2; FABP3; FABP4; FABP5; PPARA; PPARD |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 4.479E-07 | 1.926E-05 | CYP1A2; CYP1A1; CYP1B1; CYP19A1 |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.112E-05 | 3.187E-04 | CYP1A2; CYP1A1; CYP1B1 |
| hsa04913 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 2.190E-05 | 4.708E-04 | CYP1A1; CYP1B1; CYP19A1 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 6.835E-05 | 1.176E-03 | CYP1A2; CYP1A1; CYP1B1 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 9.670E-05 | 1.386E-03 | CYP1A2; CYP1A1; CYP1B1 |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.415E-03 | 1.739E-02 | POLB; SYK; TP53 |
| hsa04923 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.716E-03 | 1.845E-02 | FABP4; TSHR |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 2.304E-03 | 2.201E-02 | CYP1A2; CYP1A1 |
| hsa04151 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 5.949E-03 | 4.651E-02 | SYK; TP53; TLR2 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 5.488E-03 | 4.651E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | PPARD; MAPT |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | SYK; TLR2 |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | SYK |
| C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1 |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | SYK; SYK |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | PPARD |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| NA: NA | Dyslipidemia | NA | PPARD |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; TP53 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53 |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | PPARD |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| C00-D49: Neoplasms | Melanoma | C43 | TLR2 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | SYK; TP53; TLR2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | PPARD |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | SYK |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | SYK; TP53 |
| C00-D49: Neoplasms | Cancer | C00-C96 | SYK; TP53; TLR2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dyslipidaemias | E78 | PPARD; PPARD |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | TLR2 |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53 |
| N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1 |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | SYK |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PPARD |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | PPARD |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | SYK |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Radiation sickness | T66 | TLR2 |
| K00-K95: Diseases of the digestive system | Non-alcoholic fatty liver disease | K76.0 | PPARD |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | SYK |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PPARD; PPARD |
| C00-D49: Neoplasms | Bladder cancer | C67 | CYP19A1 |
| C00-D49: Neoplasms | Breast cancer | C50 | CYP19A1 |
| C00-D49: Neoplasms | B-cell lymphoma | C85.1 | SYK |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | SYK |
| C00-D49: Neoplasms | Prostate cancer | C61 | TLR2 |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1 |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | TLR2 |