Plant Name: Gardenia jasminoides
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| OPRD1; TSHR; NPSR1; CXCR1; NMUR2; | |
| DRD4; ADRA2C; ADRA2A; | |
| ALPL; PLA2G1B; TDP1; ALPI; RECQL; P4HB; TERT; PKM; PIK3R1; GLO1; HPGD; PGD; MPO; AKR1B1; HSD17B10; ALOX15; ALDH1A1; HSD17B2; ALOX12; GFER; AKR1B10; NOX4; PYGL; APEX1; POLB; | |
| PTPN1; | |
| ACHE; GAA; | |
| BCL2; | |
| AKT1; MET; CAMK2B; CSNK2A1; DAPK1; NEK2; FLT3; SRC; IGF1R; PTK2; AURKB; AURKA; DYRK1A; GSK3B; CDK1; MAPK1; MAPK14; PIM1; NUAK1; ALK; AXL; NEK6; KIT; KDR; PKN1; | |
| CA12; CA7; CA3; CA5B; CA1; CA9; CA14; CA4; CA6; CA2; CA5A; | |
| NR1H4; | |
| PPARA; PPARD; | |
| ESR2; | |
| KDM4E; | |
| MAOA; PTGS1; ALOX5; XDH; | |
| CASP7; CASP1; | |
| MMP13; MMP3; MMP2; MMP14; MMP9; MMP1; | |
| BACE1; | |
| TLR2; | |
| STAT6; HIF1A; NFKB1; TP53; | |
| DNMT1; | |
| FUT7; | |
| ABCC1; ABCB1; ABCG2; | |
| SLCO1B3; SLCO1B1; | |
| LMNA; FABP5; FABP2; FABP4; MAPT; FABP3; HTT; RAB9A; NPC1; APP; | |
| L3MBTL1; SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
| ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 2 | CYP2C8 | Cytochrome P450 2C8 | P10632 | CHEMBL3721 |
| Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| DNA methyltransferase | DNMT1 | DNA (cytosine-5)-methyltransferase 1 | P26358 | CHEMBL1993 |
| Enzyme_unclassified | PYGL | Liver glycogen phosphorylase | P06737 | CHEMBL2568 |
| Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Enzyme_unclassified | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | ALPI | Intestinal alkaline phosphatase | P09923 | CHEMBL5573 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | P4HB | Protein disulfide-isomerase | P07237 | CHEMBL5422 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Enzyme_unclassified | PKM | Pyruvate kinase isozymes M1/M2 | P14618 | CHEMBL1075189 |
| Enzyme_unclassified | PIK3R1 | PI3-kinase p85-alpha subunit | P27986 | CHEMBL2506 |
| Enzyme_unclassified | GLO1 | Glyoxalase I | Q04760 | CHEMBL2424 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | PGD | 6-phosphogluconate dehydrogenase | P52209 | CHEMBL3404 |
| Enzyme_unclassified | MPO | Myeloperoxidase | P05164 | CHEMBL2439 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | P37059 | CHEMBL2789 |
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Enzyme_unclassified | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA3 | Carbonic anhydrase III | P07451 | CHEMBL2885 |
| Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
| Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
| Metallo protease | MMP13 | Matrix metalloproteinase 13 | P45452 | CHEMBL280 |
| Metallo protease | MMP3 | Matrix metalloproteinase 3 | P08254 | CHEMBL283 |
| Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Metallo protease | MMP14 | Matrix metalloproteinase 14 | P50281 | CHEMBL3869 |
| Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Miscellaneous ion channel | BCL2 | Apoptosis regulator Bcl-2 | P10415 | CHEMBL4860 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Oxidoreductase | XDH | Xanthine dehydrogenase | P47989 | CHEMBL1929 |
| Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| Oxidoreductase | PTGS1 | Cyclooxygenase-1 | P23219 | CHEMBL221 |
| Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Peptide receptor (family A GPCR) | OPRD1 | Delta opioid receptor | P41143 | CHEMBL236 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Peptide receptor (family A GPCR) | CXCR1 | Interleukin-8 receptor A | P25024 | CHEMBL4029 |
| Peptide receptor (family A GPCR) | NMUR2 | Neuromedin-U receptor 2 | Q9GZQ4 | CHEMBL1075144 |
| Protein Kinase | AKT1 | Serine/threonine-protein kinase AKT | P31749 | CHEMBL4282 |
| Protein Kinase | MET | Hepatocyte growth factor receptor | P08581 | CHEMBL3717 |
| Protein Kinase | CAMK2B | CaM kinase II beta | Q13554 | CHEMBL4121 |
| Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
| Protein Kinase | DAPK1 | Death-associated protein kinase 1 | P53355 | CHEMBL2558 |
| Protein Kinase | NEK2 | Serine/threonine-protein kinase NEK2 | P51955 | CHEMBL3835 |
| Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
| Protein Kinase | SRC | Tyrosine-protein kinase SRC | P12931 | CHEMBL267 |
| Protein Kinase | IGF1R | Insulin-like growth factor I receptor | P08069 | CHEMBL1957 |
| Protein Kinase | PTK2 | Focal adhesion kinase 1 | Q05397 | CHEMBL2695 |
| Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Protein Kinase | AURKA | Serine/threonine-protein kinase Aurora-A | O14965 | CHEMBL4722 |
| Protein Kinase | DYRK1A | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Q13627 | CHEMBL2292 |
| Protein Kinase | GSK3B | Glycogen synthase kinase-3 beta | P49841 | CHEMBL262 |
| Protein Kinase | CDK1 | Cyclin-dependent kinase 1 | P06493 | CHEMBL308 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Protein Kinase | MAPK14 | MAP kinase p38 alpha | Q16539 | CHEMBL260 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Protein Kinase | NUAK1 | NUAK family SNF1-like kinase 1 | O60285 | CHEMBL5784 |
| Protein Kinase | ALK | ALK tyrosine kinase receptor | Q9UM73 | CHEMBL4247 |
| Protein Kinase | AXL | Tyrosine-protein kinase receptor UFO | P30530 | CHEMBL4895 |
| Protein Kinase | NEK6 | Serine/threonine-protein kinase NEK6 | Q9HC98 | CHEMBL4309 |
| Protein Kinase | KIT | Stem cell growth factor receptor | P10721 | CHEMBL1936 |
| Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| Protein Kinase | PKN1 | Protein kinase N1 | Q16512 | CHEMBL3384 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Small molecule receptor (family A GPCR) | DRD4 | Dopamine D4 receptor | P21917 | CHEMBL219 |
| Small molecule receptor (family A GPCR) | ADRA2C | Alpha-2c adrenergic receptor | P18825 | CHEMBL1916 |
| Small molecule receptor (family A GPCR) | ADRA2A | Alpha-2a adrenergic receptor | P08913 | CHEMBL1867 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Transcription Factor | STAT6 | Signal transducer and activator of transcription 6 | P42226 | CHEMBL5401 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Transferase | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Q11130 | CHEMBL3596077 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | APP | Beta amyloid A4 protein | P05067 | CHEMBL2487 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 7.389E-12 | 1.828E-09 | ALPI, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR2, GLO1, L3MBTL1, MMP1, MMP13, MMP14, MMP2, MMP3, MMP9, NR1H4, PPARA, PPARD, PTPN1, TP53 |
| BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 4.364E-11 | 9.051E-09 | AKT1, AURKA, AURKB, BCL2, CAMK2B, CDK1, DYRK1A, GSK3B, MAPK1, MAPK14, NEK6, PKN1, SRC |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 4.917E-10 | 8.173E-08 | ABCB1, ABCC1, ABCG2, AKT1, ALK, AURKA, AURKB, AXL, CAMK2B, CDK1, CSNK2A1, DAPK1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAPK1, MAPK14, MET, NEK2, NEK6, NUAK1, PIM1, PKM, PKN1, PTK2, PYGL, RECQL, SRC, TP53 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 5.758E-10 | 9.357E-08 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C8, CYP3A4, MPO, NOX4, PTGS1, SRC |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 1.193E-09 | 1.791E-07 | AKT1, BCL2, HIF1A, LMNA, OPRD1, P4HB, PPARD, SRC, TERT, TP53 |
| BP | GO:0008152; metabolic process | GO:0018107; peptidyl-threonine phosphorylation | 1.614E-09 | 2.312E-07 | AKT1, BCL2, CAMK2B, CDK1, CSNK2A1, DYRK1A, GSK3B, MAPK1, PKN1 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 5.447E-09 | 7.060E-07 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP3A4 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 6.185E-09 | 7.876E-07 | ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C8, CYP3A4, XDH |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.327E-08 | 1.570E-06 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP3A4, NOX4 |
| BP | Unclassified; | GO:0032846; positive regulation of homeostatic process | 2.255E-08 | 2.585E-06 | AURKB, CA2, CA7, HIF1A, HTT, MAPK1, MAPK14, NEK2, NPC1, NPSR1, NR1H4, PLA2G1B |
| BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 3.811E-08 | 4.108E-06 | ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B, TLR2 |
| BP | Unclassified; | GO:0032844; regulation of homeostatic process | 5.882E-08 | 6.128E-06 | ADRA2A, AURKB, BCL2, CA2, CA7, HIF1A, HTT, KDR, MAPK1, MAPK14, NEK2, NPC1, NPSR1, NR1H4, PLA2G1B, SRC |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 1.809E-07 | 1.677E-05 | CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C8 |
| MF | GO:0003824; catalytic activity | GO:0004712; protein serine/threonine/tyrosine kinase activity | 2.564E-07 | 2.298E-05 | AKT1, AURKA, AURKB, DYRK1A, MAPK1, MAPK14 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 3.192E-07 | 2.814E-05 | CYP1A1, CYP1A2, CYP1B1, CYP2C8 |
| BP | GO:0065007; biological regulation | GO:0000187; activation of MAPK activity | 3.337E-07 | 2.926E-05 | ALK, CDK1, DRD4, KIT, MAPK1, MAPK14, PKN1, PLA2G1B, PTPN1 |
| BP | GO:0009987; cellular process | GO:0071407; cellular response to organic cyclic compound | 3.838E-07 | 3.286E-05 | AKT1, ALPL, APEX1, APP, CASP7, CYP1A1, CYP1B1, FLT3, MAPK1, NFKB1, NOX4, NPC1, SRC |
| BP | Unclassified; | GO:0044236; multicellular organism metabolic process | 3.849E-07 | 3.286E-05 | HIF1A, MMP1, MMP13, MMP14, MMP2, MMP3, MMP9, PLA2G1B |
| BP | Unclassified; | GO:0044243; multicellular organismal catabolic process | 4.112E-07 | 3.484E-05 | MMP1, MMP13, MMP14, MMP2, MMP3, MMP9, PLA2G1B |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 7.450E-07 | 5.856E-05 | CYP1A2, CYP2A6, CYP2C8, CYP3A4 |
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 8.432E-07 | 6.558E-05 | AKT1, BCL2, MAPT, PTPN1, TP53 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 1.003E-06 | 7.533E-05 | CYP1A2, CYP2C8, CYP3A4 |
| BP | Unclassified; | GO:0044259; multicellular organismal macromolecule metabolic process | 1.266E-06 | 9.285E-05 | HIF1A, MMP1, MMP13, MMP14, MMP2, MMP3, MMP9 |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 1.880E-06 | 1.329E-04 | AKR1B1, AKR1B10, AKT1, ALDH1A1, ALOX12, ALOX15, ALOX5, APP, AURKA, AURKB, BCL2, CA1, CA2, CA3, CA7, CAMK2B, CASP1, CASP7, CDK1, CSNK2A1, FABP2, FABP3, FABP4, FABP5, FLT3, GFER, GLO1, GSK3B, HIF1A, HPGD, HTT, LMNA, MAPK1, MAPK14, MAPT, MMP14, NEK2, NEK6, NFKB1, PGD, PIK3R1, PIM1, PKM, PKN1, PLA2G1B, PTK2, PTPN1, PYGL, RAB9A, SMN1, SMN2, SRC, STAT6, TP53, XDH |
| BP | GO:0009987; cellular process | GO:1901796; regulation of signal transduction by p53 class mediator | 1.905E-06 | 1.338E-04 | AKT1, AURKA, AURKB, CSNK2A1, DYRK1A, L3MBTL1, MAPK14, NUAK1, TP53 |
| BP | GO:0009987; cellular process | GO:0070301; cellular response to hydrogen peroxide | 2.459E-06 | 1.674E-04 | AKR1B1, APEX1, AXL, CDK1, CYP1B1, STAT6 |
| MF | GO:0003824; catalytic activity | GO:0101020; estrogen 16-alpha-hydroxylase activity | 2.496E-06 | 1.688E-04 | CYP1A1, CYP2C8, CYP3A4 |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 2.570E-06 | 1.733E-04 | AKR1B1, AKT1, ALOX5, APEX1, AURKA, AURKB, BCL2, CAMK2B, CASP7, CDK1, CSNK2A1, DNMT1, DYRK1A, ESR2, FABP5, GSK3B, HIF1A, HPGD, HTT, L3MBTL1, LMNA, MAPK1, MAPK14, NEK2, NEK6, NFKB1, NR1H4, NUAK1, PIM1, PKN1, POLB, PPARA, PPARD, RECQL, SMN1, SMN2, SRC, STAT6, TERT, TP53 |
| BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 2.686E-06 | 1.799E-04 | ALOX12, ALOX15, ALOX5, HPGD |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 3.005E-06 | 1.989E-04 | ABCC1, ADRA2A, CA2, CA4, CA9, HPGD, SLCO1B1, SLCO1B3, TSHR |
| BP | GO:0008152; metabolic process | GO:0030574; collagen catabolic process | 3.583E-06 | 2.315E-04 | MMP1, MMP13, MMP14, MMP2, MMP3, MMP9 |
| BP | GO:0008152; metabolic process | GO:0002933; lipid hydroxylation | 4.969E-06 | 3.092E-04 | CYP1A1, CYP2C8, CYP3A4 |
| CC | GO:0044464; cell part | GO:0005739; mitochondrion | 6.174E-06 | 3.714E-04 | AKT1, APEX1, BCL2, CA5A, CA5B, CASP1, CDK1, CYP1A1, CYP1B1, ESR2, GFER, GSK3B, HSD17B10, MAOA, MAPK1, MAPK14, MMP2, MPO, NFKB1, NOX4, PKM, SRC, TP53 |
| BP | GO:0009987; cellular process | GO:0048010; vascular endothelial growth factor receptor signaling pathway | 6.537E-06 | 3.921E-04 | AXL, KDR, MAPK14, PIK3R1, PTK2, SRC |
| BP | GO:0009987; cellular process | GO:0030168; platelet activation | 6.612E-06 | 3.956E-04 | ADRA2A, ADRA2C, AKT1, AXL, MAPK1, PIK3R1, SRC |
| BP | GO:0051179; localization | GO:0046326; positive regulation of glucose import | 7.652E-06 | 4.502E-04 | AKT1, MAPK14, NR1H4, PIK3R1, TERT |
| BP | GO:0008152; metabolic process | GO:0031331; positive regulation of cellular catabolic process | 8.450E-06 | 4.880E-04 | ADRA2A, AKT1, AURKA, CDK1, DAPK1, GSK3B, HIF1A, HTT, KDR, PPARA, PTK2, PTPN1 |
| MF | GO:0005215; transporter activity | GO:0008559; xenobiotic transmembrane transporting ATPase activity | 8.656E-06 | 4.973E-04 | ABCB1, ABCC1, ABCG2 |
| BP | GO:0032502; developmental process | GO:0031100; animal organ regeneration | 8.959E-06 | 5.120E-04 | AURKA, AXL, CDK1, CSNK2A1, FLT3, PKM |
| BP | GO:0008283; cell proliferation | GO:1904707; positive regulation of vascular smooth muscle cell proliferation | 1.048E-05 | 5.896E-04 | HPGD, MMP2, MMP9, TERT |
| BP | GO:0009987; cellular process | GO:0022617; extracellular matrix disassembly | 1.121E-05 | 6.246E-04 | MMP1, MMP13, MMP14, MMP2, MMP3, MMP9 |
| MF | Unclassified; | GO:0032403; protein complex binding | 1.175E-05 | 6.508E-04 | ACHE, ADRA2A, APEX1, FLT3, IGF1R, KDR, MMP13, MMP14, MMP9, P4HB, PIK3R1, PKM, PPARA, PTPN1, SRC, TLR2, TSHR |
| MF | GO:0005488; binding | GO:0051379; epinephrine binding | 1.379E-05 | 7.542E-04 | ADRA2A, ADRA2C, DRD4 |
| BP | GO:0032502; developmental process | GO:0045597; positive regulation of cell differentiation | 1.521E-05 | 8.261E-04 | ADRA2C, AKT1, APP, AURKA, AXL, BCL2, CA2, CAMK2B, HIF1A, KDR, KIT, MAPK14, MAPT, MMP14, NFKB1, PPARD, TERT, TLR2 |
| BP | GO:0065007; biological regulation | GO:0010952; positive regulation of peptidase activity | 1.576E-05 | 8.496E-04 | APP, CASP1, CASP7, DAPK1, MAPK14, MAPT, MMP14, XDH |
| BP | GO:0008152; metabolic process | GO:0031324; negative regulation of cellular metabolic process | 1.743E-05 | 9.324E-04 | ADRA2A, AKT1, APEX1, APP, AURKB, BCL2, CDK1, CSNK2A1, DAPK1, DNMT1, DRD4, DYRK1A, ESR2, FABP4, GSK3B, HIF1A, IGF1R, L3MBTL1, MAPK14, MAPT, MET, MMP3, MMP9, NFKB1, NPC1, NR1H4, PKN1, PPARA, PPARD, PTPN1, SRC, STAT6, TERT, TP53, XDH |
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 1.786E-05 | 9.461E-04 | FABP2, FABP3, FABP4, FABP5 |
| MF | GO:0005488; binding | GO:0019901; protein kinase binding | 1.903E-05 | 1.001E-03 | ADRA2A, AKT1, AURKA, GSK3B, HIF1A, MAPK1, MAPK14, NEK6, PIK3R1, PKN1, PTK2, PTPN1, SRC, TP53 |
| BP | GO:0009987; cellular process | GO:0050714; positive regulation of protein secretion | 1.980E-05 | 1.034E-03 | ACHE, CASP1, HIF1A, MAPK14, NR1H4, PLA2G1B, PPARD, SRC, TLR2 |
| MF | GO:0005488; binding | GO:0032052; bile acid binding | 2.058E-05 | 1.061E-03 | NR1H4, PLA2G1B, PYGL |
| BP | GO:0008152; metabolic process | GO:2000379; positive regulation of reactive oxygen species metabolic process | 2.373E-05 | 1.185E-03 | AKT1, MAPK14, MAPT, NOX4, TP53, XDH |
| BP | GO:0008152; metabolic process | GO:0016572; histone phosphorylation | 2.848E-05 | 1.369E-03 | AURKA, AURKB, CDK1, PKN1 |
| BP | GO:0051179; localization | GO:2001225; regulation of chloride transport | 2.927E-05 | 1.391E-03 | ABCB1, CA2, CA7 |
| BP | GO:0051179; localization | GO:0042908; xenobiotic transport | 2.927E-05 | 1.391E-03 | ABCB1, ABCC1, ABCG2 |
| BP | GO:0009987; cellular process | GO:2001243; negative regulation of intrinsic apoptotic signaling pathway | 3.228E-05 | 1.525E-03 | AKT1, BCL2, HIF1A, MMP9, PTPN1, SRC |
| BP | GO:0050896; response to stimulus | GO:0009612; response to mechanical stimulus | 3.573E-05 | 1.673E-03 | AKT1, CASP1, KIT, MAPK14, MMP14, MPO, NFKB1, SRC |
| BP | GO:0008152; metabolic process | GO:0043552; positive regulation of phosphatidylinositol 3-kinase activity | 3.774E-05 | 1.749E-03 | FLT3, KIT, PTK2, SRC |
| BP | GO:0051179; localization | GO:0042307; positive regulation of protein import into nucleus | 3.849E-05 | 1.779E-03 | APP, CDK1, MAPK1, MAPK14, PIK3R1, TLR2 |
| BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 4.022E-05 | 1.832E-03 | APEX1, POLB |
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 4.022E-05 | 1.832E-03 | ALOX12, ALOX15 |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 4.005E-05 | 1.832E-03 | GSK3B, HTT, MAPT |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 4.022E-05 | 1.832E-03 | ALOX12, ALOX15 |
| BP | GO:0050896; response to stimulus | GO:0031663; lipopolysaccharide-mediated signaling pathway | 4.312E-05 | 1.929E-03 | AKT1, MAPK1, MAPK14, TLR2 |
| BP | GO:0009987; cellular process | GO:0071276; cellular response to cadmium ion | 4.312E-05 | 1.929E-03 | AKT1, CYP1A2, MAPK1, MMP9 |
| MF | GO:0005488; binding | GO:0051879; Hsp90 protein binding | 4.904E-05 | 2.170E-03 | CSNK2A1, HIF1A, KDR, MAPT |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 5.316E-05 | 2.337E-03 | CYP1A2, CYP2C8, CYP3A4 |
| BP | GO:0009987; cellular process | GO:0051897; positive regulation of protein kinase B signaling | 5.390E-05 | 2.362E-03 | AXL, KIT, MET, NOX4, PIK3R1, PTK2, SRC |
| BP | Unclassified; | GO:2000021; regulation of ion homeostasis | 5.642E-05 | 2.447E-03 | BCL2, CA2, CA7, HTT, KDR, NPSR1, PLA2G1B, SRC |
| BP | GO:0008152; metabolic process | GO:0006081; cellular aldehyde metabolic process | 5.872E-05 | 2.507E-03 | AKR1B10, ALDH1A1, CYP1B1, GLO1, PGD |
| BP | GO:0002376; immune system process | GO:0043312; neutrophil degranulation | 5.965E-05 | 2.537E-03 | ALOX5, CXCR1, FABP5, GAA, MAPK1, MAPK14, MMP9, MPO, NFKB1, PKM, PYGL, TLR2 |
| BP | GO:0065007; biological regulation | GO:0032148; activation of protein kinase B activity | 6.263E-05 | 2.633E-03 | ADRA2A, ADRA2C, AKT1, SRC |
| BP | GO:0009987; cellular process | GO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling | 6.321E-05 | 2.647E-03 | FLT3, KDR, KIT, PPARD, PTK2 |
| BP | GO:0065007; biological regulation | GO:0042593; glucose homeostasis | 7.166E-05 | 2.955E-03 | ADRA2A, AKT1, HIF1A, NOX4, NR1H4, PIK3R1, PYGL |
| BP | GO:0008152; metabolic process | GO:0045913; positive regulation of carbohydrate metabolic process | 7.299E-05 | 2.993E-03 | AKT1, HIF1A, NFKB1, PPARA, SRC |
| BP | GO:0040011; locomotion | GO:0014911; positive regulation of smooth muscle cell migration | 7.877E-05 | 3.212E-03 | BCL2, NOX4, SRC, TERT |
| MF | GO:0005488; binding | GO:0046982; protein heterodimerization activity | 7.986E-05 | 3.250E-03 | ADRA2A, ADRA2C, AURKA, AXL, BCL2, HIF1A, NFKB1, P4HB, PIK3R1, PPARD, TLR2, TP53 |
| MF | GO:0005488; binding | GO:0002039; p53 binding | 8.389E-05 | 3.389E-03 | GSK3B, HIF1A, HTT, NUAK1, TP53 |
| BP | GO:0009987; cellular process | GO:0045742; positive regulation of epidermal growth factor receptor signaling pathway | 8.788E-05 | 3.524E-03 | ADRA2A, ADRA2C, AKT1, MMP9 |
| MF | GO:0005488; binding | GO:0001221; transcription cofactor binding | 8.788E-05 | 3.524E-03 | NEK6, PPARA, TERT, TP53 |
| MF | GO:0003824; catalytic activity | GO:0004222; metalloendopeptidase activity | 9.423E-05 | 3.765E-03 | MMP1, MMP13, MMP14, MMP2, MMP3, MMP9 |
| BP | GO:0009987; cellular process | GO:0097194; execution phase of apoptosis | 9.774E-05 | 3.884E-03 | AKT1, CASP1, CASP7, PTK2 |
| BP | GO:0051179; localization | GO:0051924; regulation of calcium ion transport | 1.008E-04 | 3.990E-03 | ADRA2A, BCL2, CAMK2B, DRD4, HTT, NPSR1, OPRD1, PLA2G1B |
| CC | GO:0016020; membrane | GO:0045121; membrane raft | 1.093E-04 | 4.266E-03 | APP, BACE1, KDR, MAPK1, NPC1, OPRD1, SRC, STAT6, TLR2 |
| MF | GO:0003824; catalytic activity | GO:0016616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 1.138E-04 | 4.426E-03 | AKR1B1, AKR1B10, HPGD, HSD17B10, HSD17B2, PGD |
| BP | GO:0032501; multicellular organismal process | GO:0014005; microglia development | 1.202E-04 | 4.542E-03 | APP, TLR2 |
| BP | GO:0051179; localization | GO:0099039; sphingolipid translocation | 1.202E-04 | 4.542E-03 | ABCB1, ABCC1 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 1.202E-04 | 4.542E-03 | CA2, CA7 |
| BP | GO:0019740; nitrogen utilization | GO:0006808; regulation of nitrogen utilization | 1.202E-04 | 4.542E-03 | BCL2, NR1H4 |
| MF | GO:0003824; catalytic activity | GO:0070576; vitamin D 24-hydroxylase activity | 1.202E-04 | 4.542E-03 | CYP1A1, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 1.202E-04 | 4.542E-03 | ALOX12, ALOX15 |
| MF | GO:0060089; molecular transducer activity | GO:0004938; alpha2-adrenergic receptor activity | 1.202E-04 | 4.542E-03 | ADRA2A, ADRA2C |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 1.202E-04 | 4.542E-03 | ALOX12, ALOX15 |
| BP | GO:0008152; metabolic process | GO:0050731; positive regulation of peptidyl-tyrosine phosphorylation | 1.216E-04 | 4.572E-03 | ADRA2A, ADRA2C, FLT3, KIT, PTPN1, SRC, TP53 |
| BP | GO:0009987; cellular process | GO:2000811; negative regulation of anoikis | 1.328E-04 | 4.952E-03 | BCL2, PTK2, SRC |
| BP | GO:0009987; cellular process | GO:0051129; negative regulation of cellular component organization | 1.419E-04 | 5.248E-03 | AKT1, APP, DNMT1, GSK3B, LMNA, MAPT, MET, MMP14, NEK2, OPRD1, PTK2, SRC, TLR2 |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 1.584E-04 | 5.787E-03 | AKT1, FABP3, NR1H4, SRC, TLR2 |
| BP | GO:0008152; metabolic process | GO:0046209; nitric oxide metabolic process | 1.605E-04 | 5.845E-03 | AKT1, CYP1B1, TLR2 |
| BP | GO:0065007; biological regulation | GO:1904355; positive regulation of telomere capping | 1.605E-04 | 5.845E-03 | AURKB, MAPK1, NEK2 |
| MF | GO:0005488; binding | GO:0042803; protein homodimerization activity | 1.618E-04 | 5.860E-03 | ABCG2, ACHE, ADRA2A, ADRA2C, AKT1, BCL2, CAMK2B, FLT3, HPGD, KIT, MAPT, NFKB1, PYGL, TERT, XDH |
| BP | GO:0009987; cellular process | GO:0000226; microtubule cytoskeleton organization | 1.631E-04 | 5.899E-03 | AURKA, AURKB, CDK1, HTT, LMNA, MAPT, NEK2, NEK6, PTK2 |
| BP | GO:0032501; multicellular organismal process | GO:0043536; positive regulation of blood vessel endothelial cell migration | 1.745E-04 | 6.271E-03 | AKT1, HIF1A, KDR, MAPK14 |
| MF | GO:0003824; catalytic activity | GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors | 1.745E-04 | 6.271E-03 | AKR1B1, AKR1B10, ALDH1A1, XDH |
| BP | GO:0009987; cellular process | GO:1901215; negative regulation of neuron death | 1.902E-04 | 6.760E-03 | AKT1, AXL, BCL2, GSK3B, HIF1A, PPARA, TERT |
| BP | GO:0009987; cellular process | GO:0090199; regulation of release of cytochrome c from mitochondria | 1.906E-04 | 6.760E-03 | AKT1, LMNA, MMP9, TP53 |
| BP | GO:0008152; metabolic process | GO:0051000; positive regulation of nitric-oxide synthase activity | 1.917E-04 | 6.788E-03 | AKT1, HIF1A, TERT |
| MF | GO:0005488; binding | GO:0042562; hormone binding | 2.107E-04 | 7.365E-03 | ACHE, ALDH1A1, IGF1R, PIK3R1, PKM |
| CC | GO:0044464; cell part | GO:0034774; secretory granule lumen | 2.166E-04 | 7.558E-03 | ALOX5, APP, FABP5, MAPK1, MAPK14, MPO, NFKB1, PKM, PYGL |
| BP | GO:0032501; multicellular organismal process | GO:0001819; positive regulation of cytokine production | 2.200E-04 | 7.666E-03 | ADRA2A, CASP1, CYP1B1, HIF1A, MAPK14, NFKB1, PIK3R1, SRC, STAT6, TLR2 |
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 2.260E-04 | 7.845E-03 | IGF1R, KDR, PTK2, SRC |
| BP | GO:0032501; multicellular organismal process | GO:0035162; embryonic hemopoiesis | 2.266E-04 | 7.845E-03 | HIF1A, KDR, KIT |
| BP | GO:0065007; biological regulation | GO:0032431; activation of phospholipase A2 activity | 2.393E-04 | 8.181E-03 | NMUR2, PLA2G1B |
| BP | GO:0065007; biological regulation | GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway | 2.393E-04 | 8.181E-03 | ADRA2A, ADRA2C |
| BP | GO:0009987; cellular process | GO:0032811; negative regulation of epinephrine secretion | 2.393E-04 | 8.181E-03 | ADRA2A, ADRA2C |
| BP | GO:0032501; multicellular organismal process | GO:0032640; tumor necrosis factor production | 2.393E-04 | 8.181E-03 | APP, TLR2 |
| BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 2.393E-04 | 8.181E-03 | CYP1A1, CYP1A2 |
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 2.658E-04 | 8.946E-03 | NR1H4, PIK3R1, PTPN1, SRC |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 2.658E-04 | 8.946E-03 | ESR2, NR1H4, PPARA, PPARD |
| BP | GO:0008152; metabolic process | GO:0001523; retinoid metabolic process | 2.753E-04 | 9.250E-03 | AKR1B10, ALDH1A1, CYP1A1, CYP1B1, PPARD |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 5.902E-22 | 4.284E-18 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 2.841E-15 | 2.062E-12 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.670E-14 | 9.323E-12 | CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.614E-21 | 7.048E-19 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.992E-12 | 1.942E-10 | CAMK2B; SRC; MMP2; PIK3R1; MAPK14; HIF1A; MMP9; PTK2; IGF1R; KDR; AKT1; MAPK1; TP53; MET; TLR2 |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 4.080E-11 | 2.652E-09 | GSK3B; FLT3; MMP1; DAPK1; MMP2; PIK3R1; HIF1A; MMP9; NFKB1; PTK2; IGF1R; KIT; BCL2; AKT1; MAPK1; MET; TP53; PPARD |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 2.964E-10 | 1.445E-08 | PKM; FLT3; KIT; AKT1; MAPK1; PIK3R1; TP53; MET; HIF1A |
| hsa05221 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 2.088E-09 | 8.144E-08 | FLT3; KIT; PIM1; AKT1; MAPK1; PIK3R1; NFKB1; PPARD |
| hsa04151 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 2.431E-08 | 4.984E-07 | GSK3B; PIK3R1; PTK2; NFKB1; IGF1R; KIT; KDR; BCL2; AKT1; MAPK1; PKN1; TP53; MET; TLR2 |
| hsa04917 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.401E-08 | 3.902E-07 | GSK3B; SRC; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1; ESR2 |
| hsa05219 | Bladder cancer_Homo sapiens_hsa05219 | 5.294E-09 | 1.721E-07 | MMP1; DAPK1; SRC; MMP2; MAPK1; MMP9; TP53 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 2.340E-08 | 4.984E-07 | SRC; BCL2; AKT1; MAPK1; STAT6; PIK3R1; TP53; MMP9; NFKB1; TLR2 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 2.812E-08 | 4.984E-07 | DNMT1; PLA2G1B; MAOA; ALOX15; AKR1B1; ALOX12; PYGL; CYP3A4; CYP19A1; HSD17B10; PTGS1; FUT7; ALOX5; HSD17B2; XDH; GAA; PGD; CYP2C8; CYP2A6; PKM; AKR1B10; CYP1A2; ALDH1A1; CYP1A1; ALPL; ALPI |
| hsa04668 | TNF signaling pathway_Homo sapiens_hsa04668 | 2.581E-08 | 4.984E-07 | MMP14; CASP7; MMP3; AKT1; MAPK1; PIK3R1; MAPK14; MMP9; NFKB1 |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 5.520E-08 | 8.281E-07 | CAMK2B; GSK3B; BCL2; AKT1; MAPK1; PIK3R1; MAPK14; TP53; NFKB1 |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 7.576E-08 | 1.055E-06 | GSK3B; BCL2; AKT1; MAPK1; PIK3R1; TP53; NFKB1; IGF1R |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 2.039E-07 | 2.339E-06 | MMP2; PIM1; BCL2; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1 |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 5.520E-08 | 8.281E-07 | OPRD1; ABCC1; BCL2; AKT1; MAPK1; PIK3R1; MAPK14; TP53; NFKB1 |
| hsa04370 | VEGF signaling pathway_Homo sapiens_hsa04370 | 9.281E-08 | 1.207E-06 | SRC; KDR; AKT1; MAPK1; PIK3R1; MAPK14; PTK2 |
| hsa05202 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.693E-07 | 2.063E-06 | HPGD; FLT3; MMP3; TP53; MPO; MMP9; MET; NFKB1; PTK2; IGF1R |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 2.374E-07 | 2.437E-06 | CAMK2B; BCL2; AKT1; MAPK1; PIK3R1; HIF1A; NFKB1; IGF1R |
| hsa04510 | Focal adhesion_Homo sapiens_hsa04510 | 4.925E-07 | 4.365E-06 | GSK3B; SRC; KDR; BCL2; AKT1; MAPK1; PIK3R1; MET; PTK2; IGF1R |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 4.535E-07 | 4.211E-06 | APP; CYP2C8; MAOA; ALOX5; ALOX15; MAPK1; ALOX12; PTGS1 |
| hsa05145 | Toxoplasmosis_Homo sapiens_hsa05145 | 6.765E-07 | 5.497E-06 | ALOX5; BCL2; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1; TLR2 |
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 2.204E-07 | 2.388E-06 | FABP2; FABP3; FABP4; FABP5; MMP1; PPARA; PPARD |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 2.689E-07 | 2.622E-06 | SLCO1B1; ABCB1; CA2; SLCO1B3; NR1H4; CYP3A4; ABCG2 |
| hsa04012 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.089E-06 | 8.171E-06 | CAMK2B; GSK3B; SRC; AKT1; MAPK1; PIK3R1; PTK2 |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 1.678E-06 | 1.169E-05 | GSK3B; AKT1; MAPK1; PIK3R1; MAPK14; PPARA; TP53; NFKB1 |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 1.985E-06 | 1.335E-05 | GSK3B; CSNK2A1; AKT1; RAB9A; PIK3R1; TP53; NFKB1; TLR2 |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 2.272E-06 | 1.342E-05 | DNMT1; ABCC1; ABCB1; PIM1; BCL2; CYP1B1; MAPK1; TP53; MMP9; MET; NFKB1 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 2.468E-06 | 1.415E-05 | CASP7; LMNA; BCL2; AKT1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa04913 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 6.095E-07 | 5.168E-06 | ALOX5; HSD17B2; CYP1A1; CYP1B1; CYP19A1; IGF1R |
| hsa05169 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 4.462E-06 | 2.290E-05 | GSK3B; CSNK2A1; BCL2; CDK1; AKT1; PIK3R1; MAPK14; TP53; NFKB1 |
| hsa04915 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 2.612E-06 | 1.455E-05 | SRC; MMP2; AKT1; MAPK1; PIK3R1; MMP9; ESR2 |
| hsa04015 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 6.357E-06 | 2.951E-05 | SRC; KIT; KDR; AKT1; MAPK1; PIK3R1; MAPK14; MET; IGF1R |
| hsa05210 | Colorectal cancer_Homo sapiens_hsa05210 | 2.220E-06 | 1.342E-05 | GSK3B; BCL2; AKT1; MAPK1; PIK3R1; TP53 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 2.220E-06 | 1.342E-05 | CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; PTGS1 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 4.969E-06 | 2.422E-05 | PTPN1; GSK3B; AKT1; PIK3R1; PYGL; PPARA; NFKB1 |
| hsa04014 | Ras signaling pathway_Homo sapiens_hsa04014 | 1.145E-05 | 4.960E-05 | PLA2G1B; KIT; KDR; AKT1; MAPK1; PIK3R1; MET; NFKB1; IGF1R |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 2.939E-06 | 1.549E-05 | CAMK2B; AKT1; MAPK1; PIK3R1; TP53; IGF1R |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.491E-06 | 1.077E-05 | CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 8.400E-06 | 3.809E-05 | GSK3B; SRC; AKT1; MAPK1; PIK3R1; TP53; HIF1A |
| hsa05218 | Melanoma_Homo sapiens_hsa05218 | 4.945E-06 | 2.422E-05 | AKT1; MAPK1; PIK3R1; TP53; MET; IGF1R |
| hsa05152 | Tuberculosis_Homo sapiens_hsa05152 | 1.450E-05 | 6.148E-05 | CAMK2B; SRC; BCL2; AKT1; MAPK1; MAPK14; NFKB1; TLR2 |
| hsa04062 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 2.072E-05 | 8.121E-05 | GSK3B; CXCR1; SRC; AKT1; MAPK1; PIK3R1; NFKB1; PTK2 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 2.939E-06 | 1.549E-05 | CYP2C8; CYP2A6; CYP1A2; ALDH1A1; CYP1A1; CYP3A4 |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 3.995E-05 | 1.443E-04 | POLB; PKM; SRC; CDK1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 6.301E-06 | 2.951E-05 | PTPN1; CSNK2A1; SRC; MAPK1; MET; IGF1R |
| hsa04912 | GnRH signaling pathway_Homo sapiens_hsa04912 | 2.082E-05 | 8.121E-05 | CAMK2B; MMP14; SRC; MMP2; MAPK1; MAPK14 |
| hsa04914 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 3.175E-05 | 1.168E-04 | CDK1; AKT1; MAPK1; PIK3R1; MAPK14; IGF1R |
| hsa05222 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.506E-05 | 6.248E-05 | BCL2; AKT1; PIK3R1; TP53; NFKB1; PTK2 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.144E-05 | 4.960E-05 | CYP2C8; CYP2A6; CYP1A2; CYP1A1; CYP1B1; CYP3A4 |
| hsa04660 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 4.442E-05 | 1.547E-04 | GSK3B; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1 |
| hsa04620 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 4.944E-05 | 1.691E-04 | AKT1; MAPK1; PIK3R1; MAPK14; NFKB1; TLR2 |
| hsa05142 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 4.442E-05 | 1.547E-04 | AKT1; MAPK1; PIK3R1; MAPK14; NFKB1; TLR2 |
| hsa04725 | Cholinergic synapse_Homo sapiens_hsa04725 | 6.400E-05 | 2.046E-04 | CAMK2B; ACHE; BCL2; AKT1; MAPK1; PIK3R1 |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 8.168E-05 | 2.528E-04 | BACE1; APP; GSK3B; CASP7; MAPK1; MAPT; HSD17B10 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 8.554E-07 | 6.672E-06 | CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4 |
| hsa05164 | Influenza A_Homo sapiens_hsa05164 | 1.055E-04 | 2.980E-04 | GSK3B; CASP1; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1 |
| hsa04611 | Platelet activation_Homo sapiens_hsa04611 | 1.082E-04 | 3.013E-04 | SRC; AKT1; MAPK1; PIK3R1; MAPK14; PTGS1 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 2.331E-04 | 6.144E-04 | CAMK2B; AKT1; MAPK1; PIK3R1; PPARA; NFKB1; TSHR |
| hsa04728 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.470E-04 | 4.037E-04 | CAMK2B; GSK3B; MAOA; AKT1; MAPK14; DRD4 |
| hsa04910 | Insulin signaling pathway_Homo sapiens_hsa04910 | 2.207E-04 | 5.897E-04 | PTPN1; GSK3B; AKT1; MAPK1; PIK3R1; PYGL |
| hsa05213 | Endometrial cancer_Homo sapiens_hsa05213 | 1.672E-05 | 6.793E-05 | GSK3B; AKT1; MAPK1; PIK3R1; TP53 |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 2.478E-04 | 6.442E-04 | GSK3B; AKT1; MAPK1; PIK3R1; MAPK14; IGF1R |
| hsa05223 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 2.410E-05 | 9.037E-05 | ALK; AKT1; MAPK1; PIK3R1; TP53 |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 3.448E-04 | 8.503E-04 | GSK3B; CASP7; AKT1; PIK3R1; PPARA; NFKB1 |
| hsa04261 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 3.096E-04 | 7.741E-04 | CAMK2B; BCL2; AKT1; MAPK1; PIK3R1; MAPK14 |
| hsa04923 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 2.410E-05 | 9.037E-05 | FABP4; AKT1; PIK3R1; TSHR; PTGS1 |
| hsa04662 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 8.718E-05 | 2.576E-04 | GSK3B; AKT1; MAPK1; PIK3R1; NFKB1 |
| hsa05211 | Renal cell carcinoma_Homo sapiens_hsa05211 | 5.368E-05 | 1.774E-04 | AKT1; MAPK1; PIK3R1; MET; HIF1A |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 5.368E-05 | 1.774E-04 | AKT1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 8.718E-05 | 2.576E-04 | AKT1; MAPK1; PIK3R1; TP53; NFKB1 |
| hsa04022 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 5.884E-04 | 1.350E-03 | OPRD1; AKT1; MAPK1; PIK3R1; ADRA2C; ADRA2A |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 6.200E-05 | 2.015E-04 | CXCR1; SRC; MAPK14; MET; NFKB1 |
| hsa05166 | HTLV-I infection_Homo sapiens_hsa05166 | 1.093E-03 | 2.317E-03 | POLB; GSK3B; TERT; AKT1; PIK3R1; TP53; NFKB1 |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 2.875E-04 | 7.281E-04 | AKT1; PIK3R1; TP53; NFKB1; IGF1R |
| hsa04750 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 3.488E-04 | 8.503E-04 | CAMK2B; SRC; ALOX12; PIK3R1; MAPK14 |
| hsa04922 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 4.010E-04 | 9.535E-04 | CAMK2B; PKM; AKT1; PYGL; PPARA |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 8.718E-05 | 2.576E-04 | CYP2A6; CYP1A2; CYP1A1; CYP1B1; CYP3A4 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 6.652E-05 | 2.092E-04 | CYP2C8; CYP2A6; MAOA; CYP1A2; CYP3A4 |
| hsa04114 | Oocyte meiosis_Homo sapiens_hsa04114 | 9.825E-04 | 2.129E-03 | CAMK2B; CDK1; MAPK1; AURKA; IGF1R |
| hsa05132 | Salmonella infection_Homo sapiens_hsa05132 | 1.897E-04 | 5.137E-04 | CASP1; MAPK1; PKN1; MAPK14; NFKB1 |
| hsa04144 | Endocytosis_Homo sapiens_hsa04144 | 5.364E-03 | 9.775E-03 | CXCR1; SRC; KIT; KDR; MET; IGF1R |
| hsa04310 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.858E-03 | 3.774E-03 | CAMK2B; GSK3B; CSNK2A1; TP53; PPARD |
| hsa04670 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 8.152E-04 | 1.794E-03 | MMP2; PIK3R1; MAPK14; MMP9; PTK2 |
| hsa04630 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 2.953E-03 | 5.759E-03 | PIM1; BCL2; AKT1; STAT6; PIK3R1 |
| hsa04380 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.346E-03 | 2.823E-03 | AKT1; MAPK1; PIK3R1; MAPK14; NFKB1 |
| hsa04072 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.975E-03 | 3.970E-03 | CXCR1; KIT; AKT1; MAPK1; PIK3R1 |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 9.920E-05 | 2.887E-04 | CASP7; CASP1; MAPK1; MAPK14; NFKB1 |
| hsa04010 | MAPK signaling pathway_Homo sapiens_hsa04010 | 4.978E-03 | 9.158E-03 | AKT1; MAPK1; MAPT; MAPK14; TP53; NFKB1 |
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 7.374E-03 | 1.307E-02 | OPRD1; NMUR2; ADRA2C; ADRA2A; DRD4; TSHR |
| hsa04068 | FoxO signaling pathway_Homo sapiens_hsa04068 | 1.392E-03 | 2.858E-03 | AKT1; MAPK1; PIK3R1; MAPK14; IGF1R |
| hsa05168 | Herpes simplex infection_Homo sapiens_hsa05168 | 5.757E-03 | 1.040E-02 | CSNK2A1; CDK1; TP53; NFKB1; TLR2 |
| hsa04060 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 2.404E-02 | 3.750E-02 | CXCR1; FLT3; KIT; KDR; MET |
| hsa04921 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.648E-02 | 2.750E-02 | CAMK2B; SRC; MAPK1; PIK3R1 |
| hsa04360 | Axon guidance_Homo sapiens_hsa04360 | 7.874E-03 | 1.371E-02 | GSK3B; MAPK1; MET; PTK2 |
| hsa04916 | Melanogenesis_Homo sapiens_hsa04916 | 3.390E-03 | 6.357E-03 | CAMK2B; GSK3B; KIT; MAPK1 |
| hsa05231 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 3.514E-03 | 6.526E-03 | AKT1; MAPK1; PIK3R1; HIF1A |
| hsa05146 | Amoebiasis_Homo sapiens_hsa05146 | 3.390E-03 | 6.357E-03 | PIK3R1; NFKB1; PTK2; TLR2 |
| hsa04666 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.972E-02 | 3.153E-02 | AKT1; MAPK1; PIK3R1 |
| hsa05323 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.809E-02 | 2.940E-02 | MMP1; MMP3; TLR2 |
| hsa04064 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.972E-02 | 3.153E-02 | CSNK2A1; BCL2; NFKB1 |
| hsa04540 | Gap junction_Homo sapiens_hsa04540 | 1.705E-02 | 2.818E-02 | SRC; CDK1; MAPK1 |
| hsa05100 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.368E-03 | 2.838E-03 | SRC; PIK3R1; MET; PTK2 |
| hsa05140 | Leishmaniasis_Homo sapiens_hsa05140 | 1.069E-03 | 2.290E-03 | MAPK1; MAPK14; NFKB1; TLR2 |
| hsa04664 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 8.187E-04 | 1.794E-03 | AKT1; MAPK1; PIK3R1; MAPK14 |
| hsa04150 | mTOR signaling pathway_Homo sapiens_hsa04150 | 5.091E-04 | 1.182E-03 | AKT1; MAPK1; PIK3R1; HIF1A |
| hsa04920 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 9.210E-03 | 1.575E-02 | AKT1; PPARA; NFKB1 |
| hsa05131 | Shigellosis_Homo sapiens_hsa05131 | 6.903E-04 | 1.565E-03 | SRC; MAPK1; MAPK14; NFKB1 |
| hsa04213 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 7.199E-03 | 1.288E-02 | AKT1; PIK3R1; IGF1R |
| hsa05321 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 7.514E-03 | 1.320E-02 | STAT6; NFKB1; TLR2 |
| hsa04621 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 4.183E-04 | 9.827E-04 | CASP1; MAPK1; MAPK14; NFKB1 |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 3.646E-04 | 8.777E-04 | CASP7; CASP1; NFKB1; TLR2 |
| hsa05014 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 2.722E-04 | 6.985E-04 | BCL2; CASP1; MAPK14; TP53 |
| hsa04973 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 3.127E-02 | 4.764E-02 | AKT1; PIK3R1 |
| hsa04930 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 3.209E-03 | 6.195E-03 | PKM; MAPK1; PIK3R1 |
| hsa04960 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 2.397E-02 | 3.750E-02 | MAPK1; PIK3R1 |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.049E-04 | 2.980E-04 | MAOA; CYP1A2; CYP1A1; CYP1B1 |
| hsa00983 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 2.841E-03 | 5.597E-03 | CYP2A6; CYP3A4; XDH |
| hsa04975 | Fat digestion and absorption_Homo sapiens_hsa04975 | 2.631E-02 | 4.040E-02 | FABP2; PLA2G1B |
| hsa02010 | ABC transporters_Homo sapiens_hsa02010 | 2.501E-03 | 4.977E-03 | ABCC1; ABCB1; ABCG2 |
| hsa00620 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.513E-02 | 3.889E-02 | PKM; GLO1 |
| hsa05216 | Thyroid cancer_Homo sapiens_hsa05216 | 1.367E-02 | 2.317E-02 | MAPK1; TP53 |
| hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.650E-02 | 2.750E-02 | AKR1B10; AKR1B1 |
| hsa03410 | Base excision repair_Homo sapiens_hsa03410 | 1.749E-02 | 2.866E-02 | POLB; APEX1 |
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.062E-02 | 3.270E-02 | AKR1B10; AKR1B1 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 8.163E-04 | 1.794E-03 | AKR1B10; GAA; AKR1B1 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 8.723E-03 | 1.505E-02 | CA2; CA4 |
| hsa00790 | Folate biosynthesis_Homo sapiens_hsa00790 | 3.253E-03 | 6.219E-03 | ALPL; ALPI |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.250E-06 | 1.342E-05 | CYP2A6; CYP1A2; XDH |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Gastrointestinal cancers | C15-C26 | KDR |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL |
| G00-G99: Diseases of the nervous system G00-G99 | Multiple scierosis | G35 | MPO |
| G00-G99: Diseases of the nervous system G00-G99 | Motor neurone disease | G12.2 | IGF1R |
| C00-D49: Neoplasms | Gliosarcoma | NA | FLT3 |
| C00-D49: Neoplasms | Osteosarcoma | C40-C41 | SRC; GSK3B |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CAMK2B; MAOA; OPRD1; ACHE; CYP3A4 |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL |
| I00-I99: Diseases of the circulatory system | Angiogenesis disorder | I00-I99 | KDR |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Cough | R05 | OPRD1 |
| A00-B99: Certain infectious and parasitic diseases | HCV infection | B17.1, B18.2 | MMP3 |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | XDH; ADRA2C |
| I00-I99: Diseases of the circulatory system | Heart disease | I00-I52 | MET |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | MMP13; MMP3; MMP2; PTGS1; ALOX5 |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | MET; AURKA |
| J00-J99: Diseases of the respiratory system | Airway inflammation | J00-J99 | FLT3 |
| H00-H59: Diseases of the eye and adnexa | Age related macular degeneration | H35.3 | APP |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | MAOA; OPRD1; ADRA2C |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis | M80-M81, Z79.890 | SRC |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | AKR1B1; PTPN1; GSK3B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | PTGS1; ALOX5 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | MAOA; ADRA2C |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| H00-H59: Diseases of the eye and adnexa | Graves' ophthalmopathy | H06.2 | IGF1R |
| C00-D49: Neoplasms | Haematological malignancies | C81-C86 | AURKA |
| H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | TERT |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | ACHE; CA4; CA2 |
| H00-H59: Diseases of the eye and adnexa | Ocular disease | H00-H59 | ADRA2C |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | ADRA2C; CA4; CA4 |
| C00-D49: Neoplasms | Ocular cancer | C69 | APEX1 |
| J00-J99: Diseases of the respiratory system | Allergic rhinitis | J00, J30, J31.0, T78.4 | PLA2G1B; ADRA2C |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | PLA2G1B; ALOX5 |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAOA; MAPT; ACHE; ACHE; ACHE; GSK3B; ADRA2C; APP |
| NA: NA | Colour dead tissues | NA | PTPN1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Sexual dysfunction | F52 | ADRA2A |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | MAOA; CASP1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Erythema | L51-L54 | ADRA2C |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Erectile dysfunction | F52.2, N48.4 | DRD4 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | MMP2; PTGS1 |
| I00-I99: Diseases of the circulatory system | Acute coronary syndrome | I74 | MAPK14 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | MAOA; MAOA; OPRD1 |
| C00-D49: Neoplasms | Malignant adrenal gland cancer | C74.0 | IGF1R |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Male sexual disorders | F52 | ADRA2C |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1; ADRA2C; PPARD; PPARD |
| K00-K95: Diseases of the digestive system | Non-alcoholic fatty liver disease | K76.0 | PPARD |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | KDR |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MET; ABCB1; DNMT1; IGF1R; IGF1R; AXL; KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
| C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR |
| C00-D49: Neoplasms | Soft tissue sarcoma | C00-D49 | DNMT1 |
| C00-D49: Neoplasms | Melanoma | C43 | TLR2; TERT; KDR; KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | MAOA; PTGS1 |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT; ACHE |
| C00-D49: Neoplasms | Medullary thyroid cancer | C73 | KDR |
| A00-B99: Certain infectious and parasitic diseases | Infections disease | A00-B99 | MPO |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1; NFKB1; PPARD |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1 |
| J00-J99: Diseases of the respiratory system | Rhinitis | J00, J30, J31.0 | ALOX5 |
| NA: NA | Rheumatold arthritis | NA | PTGS1; MAPK14 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CAMK2B; AKR1B1; PLA2G1B; CASP1; OPRD1; MMP3; ALOX5; MAPK14; MMP1 |
| C00-D49: Neoplasms | Chronic myelogenous leukaemia | C92.1 | SRC |
| NA: NA | Upper abdominal bloating | NA | ACHE |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA1; CA2 |
| NA: NA | Dyslipidemia | NA | PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dyslipidaemias | E78 | PPARD; PPARD |
| N00-N99: Diseases of the genitourinary system | Dysmenorrhea | N94.4-N94.6 | PTGS1 |
| NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | PPARD |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | KDR |
| C00-D49: Neoplasms | Mesothelioma | C45 | PTK2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | GAA |
| I00-I99: Diseases of the circulatory system | Myocardial infarction | I21, I22 | MMP3 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Nerve injury | T14.4 | PLA2G1B |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MPO; PLA2G1B; MMP13; PTGS1; ALOX5; MAPK14; KIT |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | DRD4 |
| G00-G99: Diseases of the nervous system G00-G99 | Encephalopathy | G93.4 | XDH |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE; APP |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE |
| C00-D49: Neoplasms | Myeloid leukemia | C92 | FLT3 |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | TLR2; DNMT1; DNMT1; KDR |
| C00-D49: Neoplasms | Myelofibrosis | C94.4, D47.4 | FLT3 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | AKT1; MET; TLR2; PKM; ABCB1; FLT3; CA9; MMP2; MMP14; SRC; IGF1R; PTK2; AURKB; AURKA; HIF1A; MAPK1; MMP9; TP53; KIT; KDR; KDR; KDR |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | KDR |
| N00-N99: Diseases of the genitourinary system | Urinary incontinence | N39.3, N39.4, R32 | OPRD1 |
| N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | PTGS1; MMP9 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PTGS1; MAPK14 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp | L20-L30 | PLA2G1B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ALOX5 |
| NA: NA | Inflammatory diseases | NA | MAPK14 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | AKT1; CA9; HIF1A; BCL2 |
| H00-H59: Diseases of the eye and adnexa | Macular degeneration | H35.3 | APP |
| C00-D49: Neoplasms | Cancer | C00-C96 | AKT1; MET; TLR2; CSNK2A1; ABCB1; CA1; FLT3; FLT3; CA9; MMP2; ACHE; DNMT1; SRC; IGF1R; PTK2; AURKA; GSK3B; HIF1A; CDK1; MAPK1; MAPK14; MMP9; NFKB1; PIM1; BCL2; BCL2; TP53; KIT; KDR; APP |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| J00-J99: Diseases of the respiratory system | Respiratory disease | J00-J99 | ALOX5 |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9; KDR |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | MMP2; KDR; KDR |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | PPARD |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Postoperative inflammation | T81 | PTGS1 |
| I00-I99: Diseases of the circulatory system | Ischemia | I99.8 | SRC |
| I00-I99: Diseases of the circulatory system | Ischemic heart diseases | I20-I25 | OPRD1 |
| I00-I99: Diseases of the circulatory system | Ischemic stroke | I61-I63 | MMP3 |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | TERT; SRC |
| C00-D49: Neoplasms | Breast cancer | C50 | TERT; CYP19A1; FLT3; FLT3; CA9; IGF1R; CDK1; BCL2; KDR; KDR; KDR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | FLT3; ALOX5; MAPK14; BCL2 |
| N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1 |
| C00-D49: Neoplasms | Prostate cancer | C61 | TLR2; TERT; FLT3; BCL2 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Pruritus | L29 | PLA2G1B; ALOX5 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Vitiligo | L80 | MAOA |
| A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |
| C00-D49: Neoplasms | Metastasis | C00-C97 | AXL |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | DNMT1; PTK2; AURKA; TP53 |
| C00-D49: Neoplasms | Leukemia | C90-C95 | AKT1; FLT3; BCL2 |
| N00-N99: Diseases of the genitourinary system | Bladder disease | N30-N32 | OPRD1 |
| C00-D49: Neoplasms | Biliary cancer | C22, C24 | KDR |
| C00-D49: Neoplasms | Ovarian cancer | C56 | TERT; ABCB1; MMP2; KDR; KDR; KDR; KDR |
| C00-D49: Neoplasms | Overactive bladder disorder | C67, N32.81 | OPRD1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriatic disorder | L40 | IGF1R |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychotic disorders | F20-F29 | DRD4 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Myocardial reperfusion injury | T86.4 | AKT1 |
| K00-K95: Diseases of the digestive system | Liver disease | K70-K77 | MET |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5 |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | MMP2 |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| C00-D49: Neoplasms | CLL | NA | FLT3 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT; ACHE |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Brain injury | S09.90 | APP |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | PLA2G1B; ABCC1; ALOX5; MAPK14; MMP1 |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PLA2G1B; ALOX5; ALOX5; ADRA2C |
| I00-I99: Diseases of the circulatory system | Arteriosclerosis | I70 | PLA2G1B |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | ALOX5; PPARD |
| C00-D49: Neoplasms | Peritoneal cavity cancer | NA | KDR |
| A00-B99: Certain infectious and parasitic diseases | Leishmaniasis | B55.0 | PLA2G1B |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | BCL2 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Attention deficit hyperactivity disorder | F90 | ADRA2A |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | TLR2 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Atopic dermatitis | L00-L99 | ALOX5 |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | ABCB1 |
| K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Growth failure | R62.8 | IGF1R |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1; ACHE |
| NA: NA | Chronic diarrhea associated with inflammatory bowel disease | NA | OPRD1 |
| K00-K95: Diseases of the digestive system | Chemotherapy-induced mucositis | K12.3 | MET |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | AKR1B1; TERT; TP53; KDR; KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT; PPARD |
| I00-I99: Diseases of the circulatory system | Cerebral amyloid angiopathy | I68.0 | APP |
| I00-I99: Diseases of the circulatory system | Hypotension | I95 | ADRA2C |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricaemia in gout | E79.0, M10 | XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricemia | E79.0 | XDH |
| C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hormone deficiency | E00-E90 | IGF1R |
| C00-D49: Neoplasms | AML | NA | FLT3; KDR |
| NA: NA | Edema | NA | CA2 |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | MPO; ALOX5; MAPK14 |
| I00-I99: Diseases of the circulatory system | Stroke | I61-I63, I80-I82 | MMP9 |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | FLT3 |
| H00-H59: Diseases of the eye and adnexa | Diabetic retinopathy | H36, E10.3, E11.3, E13.3 | MAPK14 |
| C00-D49: Neoplasms | Bladder cancer | C67 | CYP19A1 |
| C00-D49: Neoplasms | Fallopian tube cancer | C57.0, D28.2 | KDR |
| NA: NA | Acute respiratory distress syndrome | NA | MAPK14 |
| NA: NA | Geographic retinal atrophy | NA | APP |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | DNMT1; SRC |
| G00-G99: Diseases of the nervous system G00-G99 | Mild to moderate alzheimer disease | G30 | APP |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic complication | E08-E13 | AKR1B1 |
| C00-D49: Neoplasms | Cutaneous Melanoma | C43-C44 | KDR |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5; RAB9A |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | MET; CASP1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Fibromyalgia | M79.7 | ADRA2C |
| C00-D49: Neoplasms | Gastric cancer | C16 | KDR; KDR |
| C00-D49: Neoplasms | Multiple myeloma | C90 | TERT; SRC; IGF1R; BCL2 |
| I00-I99: Diseases of the circulatory system | Coronary artery disease | I20-I25 | MAPK14; MAPK14 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mood disorder | F30-F39 | MAOA |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Contusion | S36.220S | ADRA2C |
| H00-H59: Diseases of the eye and adnexa | Corneal ulcers | H16.0 | MMP3 |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| C00-D49: Neoplasms | Adrenocortical carcinoma | C74.0 | ABCB1 |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1; SRC |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | MPO; MAOA; ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; KDR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Contact dermatitis | L23, L24, L25 | PLA2G1B |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | FLT3; PTGS1; IGF1R; MMP9; TP53; KDR |
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL; FLT3 |
| C00-D49: Neoplasms | Hematologic malignancies | C81-C86 | AKT1 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | SRC; AURKB; TP53 |
| NA: NA | Hematopoietic stem cell transplantation | NA | FLT3 |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | MET; IGF1R; KDR |
| C00-D49: Neoplasms | Advanced malignancies | C00-C96 | KDR |
| C00-D49: Neoplasms | Advanced melanoma | C43 | BCL2 |
| C00-D49: Neoplasms | Advanced renal cell carcinoma | C64 | KDR; KDR |
| C00-D49: Neoplasms | Refractory renal cell carcinoma | C64 | PKM |
| I00-I99: Diseases of the circulatory system | Hypertension | I10-I16 | ADRA2C |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | PPARD |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Premature ejaculation | F52.4 | OPRD1 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Radiation sickness | T66 | TLR2 |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | ADRA2C; NPSR1; APP |
| C00-D49: Neoplasms | Metastatic HER2-negative gastric cancer | NA | MET |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3 |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| C00-D49: Neoplasms | Tumors | C00-D48 | TERT |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE; ADRA2C |
| NA: NA | Acute nonspecific diarrhea | NA | OPRD1 |
| G00-G99: Diseases of the nervous system G00-G99 | Acute migraine | G43 | OPRD1 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TERT; FLT3; FLT3; DNMT1; DNMT1; AURKB; AURKA; TP53; TP53 |
| J00-J99: Diseases of the respiratory system | Acute lung injury | J80 | MAPK14 |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | ALOX5 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | AKR1B1; PTGS1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic nephropathy | E11.21 | ADRA2C; MMP1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic cataract | E10.36, E11.36 | AKR1B1 |
| G00-G99: Diseases of the nervous system G00-G99 | Diagnostic imaging | G30, I73.9 | APP |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | AKR1B1; ABCC1; ABCC1; XDH |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | AKR1B1; CA1; CA1; ACHE; ADRA2C |
| NA: NA | GIST | NA | FLT3 |
| C00-D49: Neoplasms | Glioma | C71 | KDR; APP |
| C00-D49: Neoplasms | Glioblastoma | NA | FLT3 |
| NA: NA | Miosis during ocular surgery | NA | PTGS1 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Moderate-to-severe pain | R52, G89 | OPRD1 |
| K00-K95: Diseases of the digestive system | Peptic ulcer | K25-K27 | ADRA2C |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | AKT1; TLR2; TERT; FLT3; MMP2; KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | PKM; MMP13; OPRD1; ACHE; PTGS1; IGF1R; CDK1; ADRA2C; ADRA2A |
| E00-E89: Endocrine, nutritional and metabolic diseases | Amyloidosis | E85 | APP |
| G00-G99: Diseases of the nervous system G00-G99 | Amyotrophic lateral sclerosis | G12.2 | BCL2 |
| NA: NA | Anaplastic mixed oligoastrocytoma | NA | FLT3 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses | L20-L30 | PLA2G1B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dietary shortage | E40-E46 | PTGS1 |
| C00-D49: Neoplasms | Liver cancer | C22 | TERT; IGF1R; KDR |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| K00-K95: Diseases of the digestive system | Diarrhea-predominant IBS | K58.0 | OPRD1 |