CMAUP Plant Collective Molecular Activities

Plant Name: Annona rensoniana

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.332E-08	1.221E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.760E-07	7.665E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.203E-07	7.995E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0046686; response to cadmium ion	5.384E-07	1.172E-03	CYP1A2, KIT, MAPK1, NPC1
BP	GO:0032501; multicellular organismal process	GO:0006940; regulation of smooth muscle contraction	9.854E-07	1.533E-03	ADRA2A, ADRA2C, KIT, NMUR2
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.934E-06	2.340E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.571E-06	2.947E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	4.066E-06	4.119E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0071310; cellular response to organic substance	5.654E-06	4.767E-03	ADRA2A, CYP1A1, CYP1B1, KDR, KIT, MAPK1, NPC1, OPRD1, TSHR
BP	GO:0050896; response to stimulus	GO:0009636; response to toxic substance	5.854E-06	4.767E-03	CYP1A1, CYP1B1, KDR, MAPK1, OPRD1, POLB
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	8.126E-06	5.204E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	8.126E-06	5.204E-03	ADRA2A, ADRA2C
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	8.126E-06	5.204E-03	CYP1A1, CYP1A2
BP	GO:0032501; multicellular organismal process	GO:0051930; regulation of sensory perception of pain	8.614E-06	5.210E-03	ADRA2C, NMUR2, OPRD1
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	9.152E-06	5.386E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1, NPC1
CC	GO:0032991; macromolecular complex	GO:0032133; chromosome passenger complex	1.353E-05	7.367E-03	AURKA, AURKB
MF	GO:0005488; binding	GO:0020037; heme binding	1.477E-05	7.847E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0042493; response to drug	1.643E-05	8.318E-03	ABCC1, CYP1A1, CYP1B1, KDR, MAPK1, NPC1, POLB
MF	GO:0003824; catalytic activity	GO:0004712; protein serine/threonine/tyrosine kinase activity	1.642E-05	8.318E-03	AURKA, AURKB, MAPK1
MF	GO:0003824; catalytic activity	GO:0035174; histone serine kinase activity	2.028E-05	9.602E-03	AURKA, AURKB

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	5.410E-07	6.222E-05	CYP1A2; CYP1A1; CYP1B1; CYP19A1
hsa00380	Tryptophan metabolism_Homo sapiens_hsa00380	1.277E-05	5.168E-04	CYP1A2; CYP1A1; CYP1B1
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.348E-05	5.168E-04	OPRD1; NMUR2; ADRA2C; ADRA2A; TSHR
hsa04913	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.514E-05	7.226E-04	CYP1A1; CYP1B1; CYP19A1
hsa04022	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	3.668E-05	8.437E-04	OPRD1; MAPK1; ADRA2C; ADRA2A
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	7.840E-05	1.503E-03	CYP1A2; CYP1A1; CYP1B1
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	1.109E-04	1.822E-03	CYP1A2; CYP1A1; CYP1B1
hsa04071	Sphingolipid signaling pathway_Homo sapiens_hsa04071	3.417E-04	4.913E-03	OPRD1; ABCC1; MAPK1
hsa04015	Rap1 signaling pathway_Homo sapiens_hsa04015	1.754E-03	2.129E-02	KIT; KDR; MAPK1
hsa04014	Ras signaling pathway_Homo sapiens_hsa04014	2.161E-03	2.129E-02	KIT; KDR; MAPK1
hsa05221	Acute myeloid leukemia_Homo sapiens_hsa05221	1.943E-03	2.129E-02	KIT; MAPK1
hsa04370	VEGF signaling pathway_Homo sapiens_hsa04370	2.221E-03	2.129E-02	KDR; MAPK1
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	2.673E-03	2.196E-02	KIT; MAPK1
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	4.607E-03	3.532E-02	ABCC1; CYP1B1; MAPK1
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	2.518E-03	2.196E-02	CYP1A2; CYP1A1
hsa04151	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	6.756E-03	4.316E-02	KIT; KDR; MAPK1
hsa04725	Cholinergic synapse_Homo sapiens_hsa04725	7.157E-03	4.332E-02	ACHE; MAPK1
hsa04916	Melanogenesis_Homo sapiens_hsa04916	5.848E-03	3.956E-02	KIT; MAPK1
hsa04114	Oocyte meiosis_Homo sapiens_hsa04114	8.723E-03	4.777E-02	MAPK1; AURKA
hsa04142	Lysosome_Homo sapiens_hsa04142	8.723E-03	4.777E-02	NPC1; GAA
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	5.737E-03	3.956E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C
C00-D49: Neoplasms	AML	NA	KDR
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	OPRD1
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	OPRD1
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR
NA: NA	Acute nonspecific diarrhea	NA	OPRD1
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	OPRD1
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKA; AURKB
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR; KDR
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C; ACHE
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A
C00-D49: Neoplasms	Gastric cancer	C16	KDR; KDR
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	KDR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Moderate-to-severe pain	R52, G89	OPRD1
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	OPRD1
C00-D49: Neoplasms	Colorectal cancer	C18-C21	KDR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	ABCC1; ABCC1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE
NA: NA	Chronic diarrhea associated with inflammatory bowel disease	NA	OPRD1
C00-D49: Neoplasms	Renal cancer	C64	KDR
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; KDR
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR; KDR
C00-D49: Neoplasms	Cancer	C00-C96	AURKA; MAPK1; KIT; KDR; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; KDR; KDR; KDR
C00-D49: Neoplasms	Solid tumours	C00-D48	AURKA; MAPK1; KIT; KDR; KDR; KDR; AURKB
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1
N00-N99: Diseases of the genitourinary system	Bladder disease	N30-N32	OPRD1
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	OPRD1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C
C00-D49: Neoplasms	Glioma	C71	KDR
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA2C; ACHE
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
K00-K95: Diseases of the digestive system	Diarrhea-predominant IBS	K58.0	OPRD1
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ABCC1
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	OPRD1; ADRA2C; ADRA2A; ACHE
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	OPRD1
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A
C00-D49: Neoplasms	Melanoma	C43	KDR; KDR
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C
C00-D49: Neoplasms	Haematological malignancies	C81-C86	AURKA
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1; KDR; KDR; KDR
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	KIT
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; KDR
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; ACHE; ACHE; ACHE
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	OPRD1; ACHE
NA: NA	Upper abdominal bloating	NA	ACHE
I00-I99: Diseases of the circulatory system	Ischemic heart diseases	I20-I25	OPRD1
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	OPRD1
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	OPRD1; ADRA2C
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	AURKA
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	AURKA
C00-D49: Neoplasms	Liver cancer	C22	KDR
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases