Plant Name: Weddellina squamulosa
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| FKBP1A; | |
| ALDH1A1; | |
| CAPN1; | |
| HIF1A; TP53; | |
| SLC2A1; | |
| XBP1; HTT; RAB9A; HSP90AA1; NPC1; LMNA; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CAPN1 | Calpain 1 | P07384 | CHEMBL3891 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Isomerase | FKBP1A | FK506-binding protein 1A | P62942 | CHEMBL1902 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| SLC superfamily of solute carriers | SLC2A1 | Glucose transporter | P11166 | CHEMBL2535 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | XBP1 | X-box-binding protein 1 | P17861 | CHEMBL1741176 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | HSP90AA1 | Heat shock protein HSP 90-alpha | P07900 | CHEMBL3880 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0006810; transport | 4.599E-07 | 4.561E-03 | CAPN1, FKBP1A, HIF1A, HSP90AA1, HTT, LMNA, NPC1, RAB9A, SLC2A1, SMN1, SMN2, XBP1 |
| CC | GO:0044422; organelle part | GO:0030018; Z disc | 1.397E-06 | 7.605E-03 | FKBP1A, SLC2A1, SMN1, SMN2 |
| BP | GO:0050896; response to stimulus | GO:0042149; cellular response to glucose starvation | 2.321E-06 | 8.423E-03 | SLC2A1, TP53, XBP1 |
| BP | GO:0051179; localization | GO:0032880; regulation of protein localization | 2.981E-06 | 8.868E-03 | FKBP1A, HIF1A, LMNA, RAB9A, SLC2A1, TP53, XBP1 |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 3.258E-06 | 8.868E-03 | ALDH1A1, CAPN1, FKBP1A, HIF1A, HSP90AA1, HTT, LMNA, RAB9A, SLC2A1, SMN1, SMN2, TP53 |
| BP | GO:0008152; metabolic process | GO:0016241; regulation of macroautophagy | 4.470E-06 | 9.955E-03 | CAPN1, HIF1A, HTT, NPC1 |
| MF | GO:0005488; binding | GO:0042802; identical protein binding | 4.777E-06 | 9.955E-03 | FKBP1A, HSP90AA1, HTT, RAB9A, SLC2A1, SMN1, SMN2, TP53 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.274E-05 | 7.516E-04 | SLC2A1; TP53; HIF1A |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 1.307E-04 | 1.928E-03 | HSP90AA1; SLC2A1; HIF1A; TP53 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 6.950E-05 | 1.928E-03 | SLC2A1; TP53; HIF1A |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 1.155E-04 | 1.928E-03 | LMNA; CAPN1; TP53 |
| hsa04141 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 2.015E-04 | 2.377E-03 | XBP1; HSP90AA1; CAPN1 |
| hsa05166 | HTLV-I infection_Homo sapiens_hsa05166 | 6.952E-04 | 6.836E-03 | XBP1; SLC2A1; TP53 |
| hsa05211 | Renal cell carcinoma_Homo sapiens_hsa05211 | 9.514E-04 | 8.019E-03 | SLC2A1; HIF1A |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 1.721E-03 | 1.269E-02 | HSP90AA1; TP53 |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 2.296E-03 | 1.505E-02 | SLC2A1; HIF1A |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 3.959E-03 | 2.336E-02 | RAB9A; TP53 |
| hsa03013 | RNA transport_Homo sapiens_hsa03013 | 6.252E-03 | 3.353E-02 | SMN2; SMN1 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 8.609E-03 | 3.907E-02 | TP53; HIF1A |
| hsa05016 | Huntington's disease_Homo sapiens_hsa05016 | 7.811E-03 | 3.840E-02 | HTT; TP53 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Melanoma | C43 | HSP90AA1; HSP90AA1 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; TP53 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | HSP90AA1; TP53 |
| C00-D49: Neoplasms | Ovarian cancer | C56 | HSP90AA1 |
| C00-D49: Neoplasms | Refractory hematological malignancies | NA | HSP90AA1 |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53 |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53 |
| C00-D49: Neoplasms | Breast cancer | C50 | HSP90AA1 |
| C00-D49: Neoplasms | Multiple myeloma | C90 | HSP90AA1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | HSP90AA1; HIF1A; TP53 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A; TP53 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53 |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |