CMAUP Plant Collective Molecular Activities

Plant Name: Atriplex parvifolia

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.741E-28	2.121E-23	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	1.238E-06	1.926E-03	ACHE, BCHE
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.712E-06	4.255E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.918E-22	8.620E-18	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.474E-20	2.436E-16	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.147E-14	3.568E-11	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9, ESR2, MMP1, MMP2, MMP9, PTPN1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	4.450E-27	3.337E-25	CA12; CA1; CA3; CA5B; CA2; CA5A; CA7; CA6; CA9; CA14
hsa05219	Bladder cancer_Homo sapiens_hsa05219	1.199E-05	4.494E-04	MMP1; MMP2; MMP9
hsa04915	Estrogen signaling pathway_Homo sapiens_hsa04915	1.692E-04	4.230E-03	MMP2; MMP9; ESR2
hsa05200	Pathways in cancer_Homo sapiens_hsa05200	8.425E-04	1.580E-02	MMP1; MMP2; MMP9; NFKB1
hsa04917	Prolactin signaling pathway_Homo sapiens_hsa04917	2.818E-03	4.227E-02	NFKB1; ESR2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; ACHE
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
NA: NA	Upper abdominal bloating	NA	ACHE
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
C00-D49: Neoplasms	Gastric cancer	C16	TOP1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1
NA: NA	Colour dead tissues	NA	PTPN1
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; NFKB1
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	TOP1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1; ACHE
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TOP1
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TOP1
C00-D49: Neoplasms	Cancer	C00-C96	CA1; CA9; MMP9; NFKB1; MMP2; TOP1; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2; TOP1
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1
C00-D49: Neoplasms	Bladder cancer	C67	TOP1
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9; MMP9; MMP2; TOP1
C00-D49: Neoplasms	Breast cancer	C50	CA9; TOP1
C00-D49: Neoplasms	Advanced ovarian cancer	NA	TOP1
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2; TOP1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1; ACHE
C00-D49: Neoplasms	Glioblastoma multiforme	C71	TOP1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1
C00-D49: Neoplasms	Renal cancer	C64	CA9
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	TOP1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9; TOP1
NA: NA	Edema	NA	CA2
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2
A00-B99: Certain infectious and parasitic diseases	Acquired immune deficiency syndrome	B20	TOP1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE
C00-D49: Neoplasms	Metastatic breast cancer	C50	TOP1; TOP1
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; ACHE; ACHE
C00-D49: Neoplasms	Esophageal cancer	C15	TOP1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases